SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aa4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		5 / 12 LEU A  17
ALA A   5
ALA A 282
VAL A  59
ARG A  58
 None
 1.24A 1cbrA-2aa4A:
undetectable		 1cbrA-2aa4A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		5 / 12 LEU A  17
ALA A   5
ALA A 282
VAL A  59
ARG A  58
 None
 1.24A 1cbrB-2aa4A:
undetectable		 1cbrB-2aa4A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		5 / 12 ILE A 183
ALA A 186
ALA A 187
GLN A 188
VAL A 243
 None
 1.05A 1fbyA-2aa4A:
undetectable		 1fbyA-2aa4A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		5 / 12 ILE A 183
ALA A 186
ALA A 187
GLN A 188
VAL A 243
 None
 1.06A 1fbyB-2aa4A:
undetectable		 1fbyB-2aa4A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		3 / 3 LEU A 250
VAL A 253
LEU A 257
 None
 0.36A 1mz9B-2aa4A:
undetectable		 1mz9B-2aa4A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		4 / 5 GLY A 182
ILE A 183
VAL A 133
SER A 217
 None
 0.98A 1rs7A-2aa4A:
undetectable		 1rs7A-2aa4A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		4 / 6 GLY A 182
ILE A 183
VAL A 133
SER A 217
 None
 0.93A 1rs7B-2aa4A:
undetectable		 1rs7B-2aa4A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		4 / 8 THR A 157
VAL A 133
GLY A 134
VAL A 125
 None
 0.91A 2a1oA-2aa4A:
undetectable		 2a1oA-2aa4A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		3 / 3 CYH A 168
CYH A 173
HIS A 156
 ZN  A1001 (-2.2A)
ZN  A1001 (-2.2A)
ZN  A1001 (-3.2A)
 0.77A 2iwkA-2aa4A:
undetectable		 2iwkA-2aa4A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		3 / 3 CYH A 168
CYH A 173
HIS A 156
 ZN  A1001 (-2.2A)
ZN  A1001 (-2.2A)
ZN  A1001 (-3.2A)
 0.76A 2iwkB-2aa4A:
undetectable		 2iwkB-2aa4A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		3 / 3 ARG A  58
GLU A 289
GLN A 287
 None
 0.90A 2p16A-2aa4A:
undetectable		 2p16A-2aa4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		5 / 12 GLY A 241
SER A 242
ALA A 246
ALA A 277
VAL A 238
 None
 1.02A 2yvlC-2aa4A:
undetectable		 2yvlC-2aa4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		4 / 7 ALA A   5
ALA A  60
ALA A  62
GLN A 287
 None
 0.86A 3a2qA-2aa4A:
undetectable		 3a2qA-2aa4A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		4 / 4 SER A 242
GLY A 241
GLY A 180
GLY A 132
 None
 0.87A 3bogB-2aa4A:
undetectable
3bogD-2aa4A:
undetectable		 3bogB-2aa4A:
undetectable
3bogD-2aa4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		3 / 3 CYH A 168
CYH A 173
HIS A 156
 ZN  A1001 (-2.2A)
ZN  A1001 (-2.2A)
ZN  A1001 (-3.2A)
 0.72A 3dtuB-2aa4A:
undetectable		 3dtuB-2aa4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		3 / 3 CYH A 168
CYH A 173
HIS A 156
 ZN  A1001 (-2.2A)
ZN  A1001 (-2.2A)
ZN  A1001 (-3.2A)
 0.69A 3dtuD-2aa4A:
undetectable		 3dtuD-2aa4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		5 / 9 ALA A 106
VAL A 133
ILE A 127
GLY A 240
THR A 131
 None
 1.05A 3el4B-2aa4A:
undetectable		 3el4B-2aa4A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		5 / 10 ILE A 183
ALA A 186
ALA A 187
GLN A 188
VAL A 243
 None
 1.05A 3falA-2aa4A:
undetectable		 3falA-2aa4A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		5 / 9 ASP A   7
ALA A  62
ILE A  67
GLY A  65
LEU A  13
 None
 1.25A 3u7sB-2aa4A:
undetectable		 3u7sB-2aa4A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		4 / 5 VAL A 253
LEU A 268
LEU A 250
ILE A 127
 None
 0.88A 4a9jA-2aa4A:
undetectable		 4a9jA-2aa4A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		4 / 5 VAL A 253
LEU A 268
LEU A 250
ILE A 127
 None
 0.87A 4a9jB-2aa4A:
undetectable		 4a9jB-2aa4A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		4 / 5 VAL A 253
LEU A 268
LEU A 250
ILE A 127
 None
 0.95A 4a9jC-2aa4A:
undetectable		 4a9jC-2aa4A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		4 / 5 GLY A 182
ILE A 183
VAL A 133
SER A 217
 None
 1.25A 4d33A-2aa4A:
undetectable		 4d33A-2aa4A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		4 / 5 GLY A 182
ILE A 183
VAL A 133
SER A 217
 None
 1.24A 4d33B-2aa4A:
undetectable		 4d33B-2aa4A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		4 / 8 LEU A  30
ALA A  15
LEU A  13
SER A  63
 None
 0.77A 4ikkA-2aa4A:
undetectable
4ikkB-2aa4A:
undetectable		 4ikkA-2aa4A:
16.96
4ikkB-2aa4A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		4 / 6 GLY A 182
ILE A 183
VAL A 133
SER A 217
 None
 0.97A 4kcnA-2aa4A:
undetectable		 4kcnA-2aa4A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		5 / 11 PHE A 126
GLY A 241
GLY A 240
ALA A 246
LEU A 245
 None
 1.06A 4l8fB-2aa4A:
undetectable		 4l8fB-2aa4A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		5 / 11 PHE A 126
GLY A 241
GLY A 240
ALA A 246
LEU A 245
 None
 1.07A 4l8fD-2aa4A:
undetectable		 4l8fD-2aa4A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		4 / 6 ARG A  27
ALA A  15
ASP A 276
LEU A  48
 None
 1.09A 4ot2A-2aa4A:
undetectable		 4ot2A-2aa4A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		5 / 12 GLN A  53
VAL A  49
LEU A  92
THR A  91
VAL A  59
 None
 1.15A 4xiwB-2aa4A:
undetectable
4xiwE-2aa4A:
undetectable		 4xiwB-2aa4A:
20.07
4xiwE-2aa4A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		5 / 12 GLY A 240
THR A 128
TYR A 249
LEU A 268
VAL A 253
 None
 1.17A 5hw4A-2aa4A:
undetectable		 5hw4A-2aa4A:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		4 / 6 GLY A   9
THR A  64
SER A  63
GLY A  65
 None
 0.87A 5k4pA-2aa4A:
undetectable		 5k4pA-2aa4A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		4 / 7 GLN A  53
VAL A  49
LEU A  92
THR A  91
 None
 0.93A 5m78A-2aa4A:
undetectable		 5m78A-2aa4A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		4 / 6 TYR A 273
LEU A 245
GLY A 241
TYR A 249
 None
 0.98A 5nooC-2aa4A:
undetectable		 5nooC-2aa4A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		5 / 12 ILE A  67
GLN A 107
VAL A 138
VAL A 125
GLU A 289
 None
 1.37A 6bzoC-2aa4A:
undetectable		 6bzoC-2aa4A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE
(Escherichia
coli) 		4 / 8 GLY A 135
VAL A 138
GLY A 241
ALA A 277
 None
 0.75A 6hu9H-2aa4A:
undetectable
6hu9e-2aa4A:
0.4		 6hu9H-2aa4A:
13.17
6hu9e-2aa4A:
17.99