SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aaf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 400
GLN A 162
ILE A  46
ARG A 399
GLY A 398
 CYR  A 406 ( 4.9A)
None
None
None
None
 1.47A 1fohA-2aafA:
undetectable		 1fohA-2aafA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 400
GLN A 162
ILE A  46
ARG A 399
GLY A 398
 CYR  A 406 ( 4.9A)
None
None
None
None
 1.47A 1fohB-2aafA:
undetectable		 1fohB-2aafA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWJ_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		5 / 9 PHE A  58
THR A 408
VAL A 362
VAL A  69
VAL A  20
 None
 1.47A 1iwjA-2aafA:
undetectable		 1iwjA-2aafA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		5 / 8 PHE A  58
THR A 408
VAL A 362
VAL A  69
VAL A  20
 None
 1.49A 1t86A-2aafA:
undetectable		 1t86A-2aafA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		5 / 9 PHE A  58
THR A 408
VAL A 362
VAL A  69
VAL A  20
 None
 1.49A 1t86B-2aafA:
0.0		 1t86B-2aafA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		3 / 3 GLY A 137
GLU A 106
ASN A 139
 None
 0.70A 1zq9A-2aafA:
undetectable		 1zq9A-2aafA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A  86
LEU A  90
ALA A 194
LEU A 190
 None
 0.88A 2vcvF-2aafA:
undetectable		 2vcvF-2aafA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 191
LEU A  90
LYS A  87
ARG A  92
 None
 1.15A 2xn3A-2aafA:
0.0
2xn3B-2aafA:
0.0		 2xn3A-2aafA:
21.16
2xn3B-2aafA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A  63
ASP A  68
ILE A 411
LEU A   8
 None
 1.01A 2ya7A-2aafA:
undetectable		 2ya7A-2aafA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A  63
ASP A  68
ILE A 411
LEU A   8
 None
 1.04A 2ya7B-2aafA:
undetectable		 2ya7B-2aafA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A  63
ASP A  68
ILE A 411
LEU A   8
 None
 1.04A 2ya7D-2aafA:
undetectable		 2ya7D-2aafA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		5 / 9 PHE A  58
THR A 408
VAL A 362
VAL A  69
VAL A  20
 None
 1.45A 3cppA-2aafA:
0.0		 3cppA-2aafA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 239
ALA A 268
VAL A 297
ASP A 227
ALA A 278
 None
None
None
None
CYR  A 406 ( 4.7A)
 0.97A 3n3iA-2aafA:
undetectable		 3n3iA-2aafA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 239
MET A 229
LEU A 270
ILE A 301
 None
 0.86A 3nbqB-2aafA:
undetectable		 3nbqB-2aafA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 239
MET A 229
LEU A 270
ILE A 301
 None
 0.81A 3nbqC-2aafA:
undetectable		 3nbqC-2aafA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 260
ALA A 261
ILE A 171
VAL A 236
GLY A 234
 None
 0.98A 3s43B-2aafA:
undetectable		 3s43B-2aafA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  76
HIS A  73
MET A  72
THR A 192
 None
 1.16A 3thrB-2aafA:
undetectable		 3thrB-2aafA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  76
HIS A  73
MET A  72
 None
 0.50A 3thrD-2aafA:
undetectable		 3thrD-2aafA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		3 / 3 LYS A  52
VAL A  48
HIS A  29
 None
 0.62A 3tj7A-2aafA:
undetectable		 3tj7A-2aafA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		4 / 6 THR A 281
ASN A 360
GLY A 358
ASP A 357
 None
CYR  A 406 ( 3.0A)
None
None
 0.83A 3w9tE-2aafA:
undetectable		 3w9tE-2aafA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		4 / 6 THR A 281
ASN A 360
GLY A 358
ASP A 357
 None
CYR  A 406 ( 3.0A)
None
None
 0.83A 3w9tF-2aafA:
undetectable		 3w9tF-2aafA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		5 / 9 ASN A 360
GLY A 403
GLY A 402
PHE A 163
GLY A 404
 CYR  A 406 ( 3.0A)
CYR  A 406 ( 4.6A)
CYR  A 406 ( 3.7A)
CYR  A 406 ( 3.9A)
CYR  A 406 ( 4.3A)
 1.23A 3ztvA-2aafA:
undetectable		 3ztvA-2aafA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		5 / 9 PHE A  58
THR A 408
VAL A 362
VAL A  69
VAL A  20
 None
 1.45A 4ek1B-2aafA:
0.0		 4ek1B-2aafA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 338
ASP A 287
ARG A 288
ILE A 416
 None
 1.43A 4mwrA-2aafA:
undetectable		 4mwrA-2aafA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		3 / 3 THR A 408
ASN A 359
PHE A 283
 None
 0.64A 4pd9A-2aafA:
undetectable		 4pd9A-2aafA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 417
LEU A 335
GLY A 334
 None
 0.58A 4xmfA-2aafA:
undetectable		 4xmfA-2aafA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		4 / 8 ARG A  31
VAL A 127
ASP A 130
ASP A 131
 None
 1.01A 4xqgA-2aafA:
undetectable		 4xqgA-2aafA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		4 / 8 ARG A  31
VAL A 127
ASP A 130
ASP A 131
 None
 1.00A 4xqgB-2aafA:
undetectable		 4xqgB-2aafA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 373
ARG A 374
TYR A 372
 None
 1.04A 5a7mA-2aafA:
undetectable		 5a7mA-2aafA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		3 / 3 ASN A 379
ASP A 357
GLY A 344
 None
 0.65A 5fctB-2aafA:
undetectable		 5fctB-2aafA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 260
ALA A 261
ILE A 171
VAL A 236
GLY A 234
 None
 0.92A 5t8hA-2aafA:
undetectable		 5t8hA-2aafA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 233
GLY A 234
ASP A 417
LEU A 338
ILE A 416
 None
 1.17A 5vooD-2aafA:
undetectable		 5vooD-2aafA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 233
GLY A 234
ASP A 417
LEU A 338
ILE A 416
 None
 1.13A 5vooF-2aafA:
undetectable		 5vooF-2aafA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 233
GLY A 234
ASP A 417
LEU A 338
ILE A 416
 None
 1.15A 5vopB-2aafA:
undetectable		 5vopB-2aafA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  41
THR A 167
ASN A 178
 CYR  A 406 ( 4.5A)
None
None
 0.72A 6baaE-2aafA:
undetectable		 6baaE-2aafA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  41
THR A 167
ASN A 178
 CYR  A 406 ( 4.5A)
None
None
 0.72A 6baaF-2aafA:
undetectable		 6baaF-2aafA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  41
THR A 167
ASN A 178
 CYR  A 406 ( 4.5A)
None
None
 0.73A 6baaG-2aafA:
undetectable		 6baaG-2aafA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  41
THR A 167
ASN A 178
 CYR  A 406 ( 4.5A)
None
None
 0.72A 6baaH-2aafA:
undetectable		 6baaH-2aafA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 398
HIS A 405
ASN A 360
GLY A 371
 None
CYR  A 406 ( 4.9A)
CYR  A 406 ( 3.0A)
None
 0.97A 6n7fA-2aafA:
undetectable		 6n7fA-2aafA:
12.18