SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aaj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IWH_A_PEMA501_1 (HEMOGLOBIN ALPHA CHAIN)	2aaj	MALONATE SEMIALDEHYDE DECARBOXYLASE (Pseudomonas pavonaceae)	5 / 6	ALA A 14 LYS A 17 ASP A 21 ALA A 22 LEU A 91	None	1.49A	1iwhA-2aajA: undetectable	1iwhA-2aajA: 21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UCK_A_SAMA2409_1 (RNA-DIRECTED RNA POLYMERASE L)	2aaj	MALONATE SEMIALDEHYDE DECARBOXYLASE (Pseudomonas pavonaceae)	3 / 3	SER A 72 ASP A 21 ASP A 37	None	0.60A	4uckA-2aajA: undetectable	4uckA-2aajA: 14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DQF_A_CZEA613_1 (SERUM ALBUMIN)	2aaj	MALONATE SEMIALDEHYDE DECARBOXYLASE (Pseudomonas pavonaceae)	5 / 9	ALA A 23 ASP A 29 LEU A 86 LEU A 87 LEU A 91	None	1.14A	5dqfA-2aajA: undetectable	5dqfA-2aajA: 12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UC3_A_486A801_2 (GLUCOCORTICOID RECEPTOR)	2aaj	MALONATE SEMIALDEHYDE DECARBOXYLASE (Pseudomonas pavonaceae)	4 / 5	LEU A 20 LEU A 19 MET A 27 TYR A 39	None	1.39A	5uc3A-2aajA: undetectable	5uc3A-2aajA: 18.46

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1IWH_A_PEMA501_1","HEMOGLOBIN ALPHA CHAIN","2aaj","MALONATE SEMIALDEHYDE DECARBOXYLASE","Pseudomonas pavonaceae",5,"ALA A  14;LYS A  17;ASP A  21;ALA A  22;LEU A  91","None","1.49A","1iwhA-2aajA:undetectable","1iwhA-2aajA:21.79"],["4UCK_A_SAMA2409_1","RNA-DIRECTED RNA POLYMERASE L","2aaj","MALONATE SEMIALDEHYDE DECARBOXYLASE","Pseudomonas pavonaceae",3,"SER A  72;ASP A  21;ASP A  37","None","0.60A","4uckA-2aajA:undetectable","4uckA-2aajA:14.91"],["5DQF_A_CZEA613_1","SERUM ALBUMIN","2aaj","MALONATE SEMIALDEHYDE DECARBOXYLASE","Pseudomonas pavonaceae",5,"ALA A  23;ASP A  29;LEU A  86;LEU A  87;LEU A  91","None","1.14A","5dqfA-2aajA:undetectable","5dqfA-2aajA:12.63"],["5UC3_A_486A801_2","GLUCOCORTICOID RECEPTOR","2aaj","MALONATE SEMIALDEHYDE DECARBOXYLASE","Pseudomonas pavonaceae",4,"LEU A  20;LEU A  19;MET A  27;TYR A  39","None","1.39A","5uc3A-2aajA:undetectable","5uc3A-2aajA:18.46"]]