SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aak'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 2aak UBIQUITIN
CONJUGATING ENZYME
(Arabidopsis
thaliana) 		5 / 9 ILE A  81
ILE A  87
LEU A 112
LEU A 113
TYR A 137
 None
 1.49A 3f78A-2aakA:
undetectable		 3f78A-2aakA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2aak UBIQUITIN
CONJUGATING ENZYME
(Arabidopsis
thaliana) 		5 / 12 LEU A  55
LEU A 113
ILE A  81
ILE A 109
TYR A 137
 None
 1.42A 4a79B-2aakA:
undetectable		 4a79B-2aakA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2aak UBIQUITIN
CONJUGATING ENZYME
(Arabidopsis
thaliana) 		4 / 8 TYR A  63
THR A  69
TRP A  96
LEU A  92
 None
 1.23A 5kxiA-2aakA:
undetectable
5kxiB-2aakA:
undetectable		 5kxiA-2aakA:
18.04
5kxiB-2aakA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2aak UBIQUITIN
CONJUGATING ENZYME
(Arabidopsis
thaliana) 		4 / 8 TYR A  63
THR A  69
TRP A  96
LEU A  92
 None
 1.30A 5kxiD-2aakA:
undetectable
5kxiE-2aakA:
undetectable		 5kxiD-2aakA:
18.04
5kxiE-2aakA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2aak UBIQUITIN
CONJUGATING ENZYME
(Arabidopsis
thaliana) 		3 / 3 ILE A  87
VAL A  70
PRO A  68
 None
 0.73A 5uunA-2aakA:
undetectable		 5uunA-2aakA:
21.33