SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aam'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
5 / 9 ILE A  92
ILE A 180
PRO A 201
ILE A 199
ILE A 186
None
0.89A 1hshB-2aamA:
undetectable
1hshB-2aamA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
5 / 12 GLY A  65
TYR A  98
SER A  62
TYR A 141
TYR A 101
UNL  A   1 ( 3.8A)
UNL  A   1 (-4.0A)
None
None
None
1.47A 1maaA-2aamA:
undetectable
1maaA-2aamA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA8_0
(GRAMICIDIN C)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 5 GLY A 115
VAL A 127
TRP A 134
TRP A 130
GOL  A 325 (-4.2A)
None
None
None
1.22A 1nt6A-2aamA:
undetectable
1nt6A-2aamA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB8_0
(GRAMICIDIN C)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 5 GLY A 115
VAL A 127
TRP A 134
TRP A 130
GOL  A 325 (-4.2A)
None
None
None
1.22A 1nt6B-2aamA:
undetectable
1nt6B-2aamA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.22A 1v54A-2aamA:
undetectable
1v54C-2aamA:
undetectable
1v54A-2aamA:
18.46
1v54C-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.18A 1v54N-2aamA:
undetectable
1v54P-2aamA:
undetectable
1v54N-2aamA:
18.46
1v54P-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.23A 1v55A-2aamA:
undetectable
1v55C-2aamA:
undetectable
1v55A-2aamA:
18.46
1v55C-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.23A 2dyrA-2aamA:
undetectable
2dyrC-2aamA:
undetectable
2dyrA-2aamA:
18.46
2dyrC-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.22A 2dyrN-2aamA:
undetectable
2dyrP-2aamA:
undetectable
2dyrN-2aamA:
18.46
2dyrP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.25A 2eijA-2aamA:
undetectable
2eijC-2aamA:
undetectable
2eijA-2aamA:
18.46
2eijC-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.21A 2eijN-2aamA:
undetectable
2eijP-2aamA:
undetectable
2eijN-2aamA:
18.46
2eijP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.22A 2eikA-2aamA:
undetectable
2eikC-2aamA:
undetectable
2eikA-2aamA:
18.46
2eikC-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.22A 2eikN-2aamA:
undetectable
2eikP-2aamA:
undetectable
2eikN-2aamA:
18.46
2eikP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.22A 2eilA-2aamA:
undetectable
2eilC-2aamA:
undetectable
2eilA-2aamA:
18.46
2eilC-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.21A 2eilN-2aamA:
undetectable
2eilP-2aamA:
undetectable
2eilN-2aamA:
18.46
2eilP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.19A 2y69A-2aamA:
undetectable
2y69C-2aamA:
undetectable
2y69A-2aamA:
18.46
2y69C-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
5 / 12 ILE A 200
LEU A 247
ASN A 206
LEU A 258
ILE A 257
None
1.21A 3a50E-2aamA:
undetectable
3a50E-2aamA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.22A 3abkA-2aamA:
undetectable
3abkC-2aamA:
undetectable
3abkA-2aamA:
18.46
3abkC-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.22A 3abkN-2aamA:
undetectable
3abkP-2aamA:
undetectable
3abkN-2aamA:
18.46
3abkP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.17A 3abmA-2aamA:
undetectable
3abmC-2aamA:
undetectable
3abmP-2aamA:
undetectable
3abmA-2aamA:
18.46
3abmC-2aamA:
19.06
3abmP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.22A 3abmN-2aamA:
undetectable
3abmP-2aamA:
undetectable
3abmN-2aamA:
18.46
3abmP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.23A 3ag2A-2aamA:
undetectable
3ag2C-2aamA:
undetectable
3ag2A-2aamA:
18.46
3ag2C-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.23A 3ag2N-2aamA:
undetectable
3ag2P-2aamA:
undetectable
3ag2N-2aamA:
18.46
3ag2P-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.22A 3ag3A-2aamA:
undetectable
3ag3C-2aamA:
undetectable
3ag3A-2aamA:
18.46
3ag3C-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.20A 3ag3N-2aamA:
undetectable
3ag3P-2aamA:
undetectable
3ag3N-2aamA:
18.46
3ag3P-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.23A 3ag4A-2aamA:
undetectable
3ag4C-2aamA:
undetectable
3ag4A-2aamA:
18.46
3ag4C-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.22A 3ag4N-2aamA:
undetectable
3ag4P-2aamA:
undetectable
3ag4N-2aamA:
18.46
3ag4P-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.21A 3asnC-2aamA:
undetectable
3asnN-2aamA:
undetectable
3asnP-2aamA:
undetectable
3asnC-2aamA:
19.06
3asnN-2aamA:
18.46
3asnP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.20A 3asoA-2aamA:
undetectable
3asoC-2aamA:
undetectable
3asoP-2aamA:
undetectable
3asoA-2aamA:
18.46
3asoC-2aamA:
19.06
3asoP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.18A 3asoC-2aamA:
undetectable
3asoN-2aamA:
undetectable
3asoP-2aamA:
undetectable
3asoC-2aamA:
19.06
3asoN-2aamA:
18.46
3asoP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
5 / 12 TYR A  39
ASN A 226
GLU A 205
ASP A 159
ARG A 157
GOL  A  14 (-4.8A)
GOL  A  12 (-4.2A)
None
None
None
1.33A 3cb8A-2aamA:
6.1
3cb8A-2aamA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.21A 3wg7A-2aamA:
undetectable
3wg7C-2aamA:
undetectable
3wg7P-2aamA:
undetectable
3wg7A-2aamA:
18.46
3wg7C-2aamA:
19.06
3wg7P-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.21A 3wg7C-2aamA:
undetectable
3wg7N-2aamA:
undetectable
3wg7P-2aamA:
undetectable
3wg7C-2aamA:
19.06
3wg7N-2aamA:
18.46
3wg7P-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TYR A  39
LEU A  41
ASN A  91
TYR A 141
GOL  A  14 (-4.8A)
UNL  A   1 (-3.9A)
None
None
1.00A 4f8yC-2aamA:
undetectable
4f8yD-2aamA:
undetectable
4f8yC-2aamA:
18.33
4f8yD-2aamA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 TRP A 102
GLU A  96
GLN A  94
GLY A  93
None
UNL  A   1 (-4.2A)
None
None
0.98A 4f93B-2aamA:
2.8
4f93B-2aamA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 ILE A  56
ILE A 200
ALA A 223
VAL A  58
None
0.72A 4jltA-2aamA:
undetectable
4jltA-2aamA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 5 ILE A 158
ARG A 172
ASP A 209
VAL A 219
None
0.89A 4nkxC-2aamA:
undetectable
4nkxC-2aamA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 5 ILE A 158
ARG A 172
ASP A 209
VAL A 219
None
0.90A 4nkxD-2aamA:
undetectable
4nkxD-2aamA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.20A 5b1aA-2aamA:
undetectable
5b1aC-2aamA:
undetectable
5b1aP-2aamA:
undetectable
5b1aA-2aamA:
18.46
5b1aC-2aamA:
19.06
5b1aP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.20A 5b1aN-2aamA:
undetectable
5b1aP-2aamA:
undetectable
5b1aN-2aamA:
18.46
5b1aP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.22A 5b1bN-2aamA:
undetectable
5b1bP-2aamA:
undetectable
5b1bN-2aamA:
18.46
5b1bP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.22A 5b3sA-2aamA:
undetectable
5b3sC-2aamA:
undetectable
5b3sP-2aamA:
undetectable
5b3sA-2aamA:
18.46
5b3sC-2aamA:
19.06
5b3sP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.21A 5b3sN-2aamA:
undetectable
5b3sP-2aamA:
undetectable
5b3sN-2aamA:
18.46
5b3sP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.22A 5iy5A-2aamA:
undetectable
5iy5C-2aamA:
undetectable
5iy5A-2aamA:
18.46
5iy5C-2aamA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
3 / 3 TYR A 262
TYR A  89
GLN A 202
None
UNL  A   1 (-3.8A)
GOL  A  14 (-2.9A)
1.08A 5jsdA-2aamA:
undetectable
5jsdB-2aamA:
undetectable
5jsdA-2aamA:
18.02
5jsdB-2aamA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
3 / 3 TYR A 262
TYR A  89
GLN A 202
None
UNL  A   1 (-3.8A)
GOL  A  14 (-2.9A)
1.09A 5jsdB-2aamA:
undetectable
5jsdC-2aamA:
undetectable
5jsdB-2aamA:
18.02
5jsdC-2aamA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
3 / 3 LYS A 103
TRP A 102
SER A 105
None
1.03A 5nwwA-2aamA:
undetectable
5nwwA-2aamA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 ARG A  99
TYR A 101
GLU A  96
LEU A 142
UNL  A   1 (-3.9A)
None
UNL  A   1 (-4.2A)
None
0.96A 5umwB-2aamA:
undetectable
5umwE-2aamA:
undetectable
5umwB-2aamA:
16.16
5umwE-2aamA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 5 ASN A 203
ASP A 156
ASN A  91
ASP A 118
GOL  A  12 (-3.3A)
GOL  A  14 (-4.0A)
None
None
1.33A 5vooA-2aamA:
6.9
5vooA-2aamA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.22A 5x1fN-2aamA:
undetectable
5x1fP-2aamA:
undetectable
5x1fN-2aamA:
18.46
5x1fP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.18A 5xdqA-2aamA:
undetectable
5xdqC-2aamA:
undetectable
5xdqP-2aamA:
undetectable
5xdqA-2aamA:
18.46
5xdqC-2aamA:
19.06
5xdqP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.20A 5xdqC-2aamA:
undetectable
5xdqN-2aamA:
undetectable
5xdqP-2aamA:
undetectable
5xdqC-2aamA:
19.06
5xdqN-2aamA:
18.46
5xdqP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.20A 5z84A-2aamA:
undetectable
5z84C-2aamA:
undetectable
5z84P-2aamA:
undetectable
5z84A-2aamA:
18.46
5z84C-2aamA:
19.06
5z84P-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.20A 5z85A-2aamA:
undetectable
5z85C-2aamA:
undetectable
5z85P-2aamA:
undetectable
5z85A-2aamA:
18.46
5z85C-2aamA:
19.06
5z85P-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.21A 5z86A-2aamA:
undetectable
5z86C-2aamA:
undetectable
5z86P-2aamA:
undetectable
5z86A-2aamA:
18.46
5z86C-2aamA:
19.06
5z86P-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.20A 5z86C-2aamA:
undetectable
5z86N-2aamA:
undetectable
5z86P-2aamA:
undetectable
5z86C-2aamA:
19.06
5z86N-2aamA:
18.46
5z86P-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.21A 5zcoA-2aamA:
undetectable
5zcoC-2aamA:
undetectable
5zcoP-2aamA:
undetectable
5zcoA-2aamA:
18.46
5zcoC-2aamA:
19.06
5zcoP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.20A 5zcoC-2aamA:
undetectable
5zcoN-2aamA:
undetectable
5zcoP-2aamA:
undetectable
5zcoC-2aamA:
19.06
5zcoN-2aamA:
18.46
5zcoP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.19A 5zcpA-2aamA:
undetectable
5zcpC-2aamA:
undetectable
5zcpP-2aamA:
undetectable
5zcpA-2aamA:
18.46
5zcpC-2aamA:
19.06
5zcpP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.20A 5zcpC-2aamA:
undetectable
5zcpN-2aamA:
undetectable
5zcpP-2aamA:
undetectable
5zcpC-2aamA:
19.06
5zcpN-2aamA:
18.46
5zcpP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 8 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.20A 5zcqA-2aamA:
undetectable
5zcqC-2aamA:
undetectable
5zcqP-2aamA:
undetectable
5zcqA-2aamA:
18.46
5zcqC-2aamA:
19.06
5zcqP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.19A 5zcqN-2aamA:
undetectable
5zcqP-2aamA:
undetectable
5zcqN-2aamA:
18.46
5zcqP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
3 / 3 LYS A  63
SER A  66
SER A  68
None
0.70A 6gbfA-2aamA:
undetectable
6gbfA-2aamA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
5 / 11 ASN A 124
TYR A 141
ASP A  97
GLY A  65
ASP A  64
UNL  A   1 ( 4.6A)
None
None
UNL  A   1 ( 3.8A)
None
1.36A 6mb5A-2aamA:
0.0
6mb5A-2aamA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
5 / 12 ARG A 191
VAL A  85
ILE A  56
PHE A 256
ILE A 146
None
1.17A 6mkeB-2aamA:
undetectable
6mkeC-2aamA:
undetectable
6mkeB-2aamA:
15.23
6mkeC-2aamA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.20A 6nmfN-2aamA:
undetectable
6nmfP-2aamA:
undetectable
6nmfN-2aamA:
18.46
6nmfP-2aamA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima)
4 / 7 TRP A 134
ASP A 143
TYR A 141
TRP A 113
None
GOL  A 326 (-2.6A)
None
None
1.23A 6nmpN-2aamA:
undetectable
6nmpP-2aamA:
undetectable
6nmpN-2aamA:
18.46
6nmpP-2aamA:
19.06