SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aao'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 2aao CALCIUM-DEPENDENT
PROTEIN KINASE,
ISOFORM AK1
(Arabidopsis
thaliana) 		5 / 11 PHE A 108
ILE A 116
LEU A 121
VAL A 142
MET A 158
 None
 0.80A 1dtlA-2aaoA:
6.2		 1dtlA-2aaoA:
36.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 2aao CALCIUM-DEPENDENT
PROTEIN KINASE,
ISOFORM AK1
(Arabidopsis
thaliana) 		5 / 12 LEU A  60
LEU A  68
MET A  32
ILE A  36
GLY A  52
 None
 1.14A 1g50B-2aaoA:
undetectable		 1g50B-2aaoA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 2aao CALCIUM-DEPENDENT
PROTEIN KINASE,
ISOFORM AK1
(Arabidopsis
thaliana) 		5 / 11 LEU A  60
LEU A  68
MET A  32
ILE A  36
GLY A  52
 None
 1.13A 1g50C-2aaoA:
undetectable		 1g50C-2aaoA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 2aao CALCIUM-DEPENDENT
PROTEIN KINASE,
ISOFORM AK1
(Arabidopsis
thaliana) 		4 / 6 ASP A 145
ASN A 146
ASP A 143
TYR A 115
 CA  A 296 (-2.9A)
None
CA  A 296 (-3.0A)
None
 1.44A 1hpkA-2aaoA:
undetectable		 1hpkA-2aaoA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2aao CALCIUM-DEPENDENT
PROTEIN KINASE,
ISOFORM AK1
(Arabidopsis
thaliana) 		4 / 7 PHE A  85
LEU A  53
VAL A  56
GLY A  57
 None
 0.92A 1t88A-2aaoA:
undetectable		 1t88A-2aaoA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2aao CALCIUM-DEPENDENT
PROTEIN KINASE,
ISOFORM AK1
(Arabidopsis
thaliana) 		5 / 12 LEU A  60
LEU A  68
MET A  32
ILE A  36
GLY A  52
 None
 1.07A 5gtrA-2aaoA:
undetectable		 5gtrA-2aaoA:
20.23