SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aaz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 7 HIS A  18
LEU A  66
THR A  67
THR A  68
 None
 0.67A 1am6A-2aazA:
undetectable		 1am6A-2aazA:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		8 / 12 LYS A  69
ILE A 100
LEU A 184
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 ( 4.1A)
CB3  A2351 (-3.6A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.28A 1axwA-2aazA:
undetectable		 1axwA-2aazA:
43.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		8 / 11 LYS A  69
ILE A 100
TRP A 101
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 ( 4.1A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.45A 1axwB-2aazA:
undetectable		 1axwB-2aazA:
43.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 11 ILE A 100
TRP A 101
LEU A 184
ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.43A 1b02A-2aazA:
undetectable		 1b02A-2aazA:
34.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 12 PHE A  72
GLU A  79
ILE A 100
TRP A 101
ASN A 104
ASP A 219
LEU A 222
GLY A 223
TYR A 259
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.68A 1hvyA-2aazA:
undetectable		 1hvyA-2aazA:
61.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 12 PHE A  72
ILE A 100
TRP A 101
ASN A 104
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.90A 1hvyA-2aazA:
undetectable		 1hvyA-2aazA:
61.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 12 GLU A  79
ILE A 100
TRP A 101
ASN A 104
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.82A 1hvyB-2aazA:
undetectable		 1hvyB-2aazA:
61.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 11 PHE A  72
GLU A  79
ILE A 100
TRP A 101
ASN A 104
ASP A 219
LEU A 222
GLY A 223
TYR A 259
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.72A 1hvyC-2aazA:
undetectable		 1hvyC-2aazA:
61.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 11 PHE A  72
ILE A 100
TRP A 101
ASN A 104
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.93A 1hvyC-2aazA:
undetectable		 1hvyC-2aazA:
61.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 12 GLU A  79
ILE A 100
TRP A 101
ASN A 104
LEU A 184
ASP A 219
LEU A 222
GLY A 223
TYR A 259
MET A 315
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.64A 1hvyD-2aazA:
undetectable		 1hvyD-2aazA:
61.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 12 ILE A 100
TRP A 101
ASN A 104
LEU A 184
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.90A 1hvyD-2aazA:
undetectable		 1hvyD-2aazA:
61.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 9 GLU A  79
ILE A 100
ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.66A 1i00A-2aazA:
undetectable		 1i00A-2aazA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 9 GLU A  79
ILE A 100
TRP A 101
LEU A 222
GLY A 223
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
 0.82A 1i00A-2aazA:
undetectable		 1i00A-2aazA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 9 ILE A 100
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.93A 1i00A-2aazA:
undetectable		 1i00A-2aazA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 9 ILE A 100
TRP A 101
LEU A 222
GLY A 223
PHE A 226
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
 1.15A 1i00A-2aazA:
undetectable		 1i00A-2aazA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 9 PHE A  72
GLU A  79
ILE A 100
ASP A 219
GLY A 223
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.67A 1i00A-2aazA:
undetectable		 1i00A-2aazA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 9 PHE A  72
GLU A  79
ILE A 100
TRP A 101
GLY A 223
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.2A)
 0.80A 1i00A-2aazA:
undetectable		 1i00A-2aazA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 9 PHE A  72
ILE A 100
ASP A 219
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 1.00A 1i00A-2aazA:
undetectable		 1i00A-2aazA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 9 PHE A  72
ILE A 100
TRP A 101
GLY A 223
PHE A 226
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
 1.21A 1i00A-2aazA:
undetectable		 1i00A-2aazA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 9 ILE A 100
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 1.07A 1i00B-2aazA:
undetectable		 1i00B-2aazA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 9 ILE A 100
TRP A 101
ASP A 219
GLY A 223
ASN A 227
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
UMP  A 350 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.80A 1i00B-2aazA:
undetectable		 1i00B-2aazA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 9 PHE A  72
ILE A 100
ASP A 219
GLY A 223
ASN A 227
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
UMP  A 350 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.74A 1i00B-2aazA:
undetectable		 1i00B-2aazA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 9 PHE A  72
ILE A 100
ASP A 219
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 1.11A 1i00B-2aazA:
undetectable		 1i00B-2aazA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 11 PHE A  72
ILE A 100
TRP A 101
ASN A 104
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.36A 1ju6A-2aazA:
undetectable		 1ju6A-2aazA:
58.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		9 / 9 LYS A  69
ILE A 100
TRP A 101
ASN A 104
ASP A 219
LEU A 222
GLY A 223
TYR A 259
MET A 315
 CB3  A2351 ( 4.1A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.35A 1ju6B-2aazA:
undetectable		 1ju6B-2aazA:
58.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		9 / 10 ILE A 100
TRP A 101
ASN A 104
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.36A 1ju6C-2aazA:
undetectable		 1ju6C-2aazA:
58.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 11 LYS A  69
PHE A  72
ILE A 100
TRP A 101
ASN A 104
ASP A 219
LEU A 222
GLY A 223
TYR A 259
MET A 315
 CB3  A2351 ( 4.1A)
CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.37A 1ju6D-2aazA:
undetectable		 1ju6D-2aazA:
58.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 10 LYS A  69
ILE A 100
TRP A 101
ASN A 104
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 ( 4.1A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.36A 1jujA-2aazA:
undetectable		 1jujA-2aazA:
58.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 10 LYS A  69
ILE A 100
TRP A 101
ASN A 104
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 ( 4.1A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.35A 1jujB-2aazA:
undetectable		 1jujB-2aazA:
58.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 10 LYS A  69
ILE A 100
TRP A 101
ASN A 104
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 ( 4.1A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.35A 1jujC-2aazA:
undetectable		 1jujC-2aazA:
58.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 10 LYS A  69
ILE A 100
TRP A 101
ASN A 104
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 ( 4.1A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.35A 1jujD-2aazA:
undetectable		 1jujD-2aazA:
58.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		3 / 3 ILE A  77
LEU A  80
VAL A  84
 None
 0.24A 1mz9B-2aazA:
undetectable		 1mz9B-2aazA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		3 / 3 LEU A  73
VAL A  76
LEU A  80
 None
 0.37A 1mz9B-2aazA:
undetectable		 1mz9B-2aazA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		3 / 3 THR A  67
LEU A  66
LEU A 220
 None
 0.54A 1mz9C-2aazA:
undetectable		 1mz9C-2aazA:
8.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 8 ILE A 100
ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.70A 1rtsA-2aazA:
undetectable		 1rtsA-2aazA:
59.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 8 ILE A 100
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 1.07A 1rtsA-2aazA:
undetectable		 1rtsA-2aazA:
59.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 8 ILE A 100
TRP A 101
ASP A 219
GLY A 223
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
 0.80A 1rtsA-2aazA:
undetectable		 1rtsA-2aazA:
59.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 8 PHE A  72
ILE A 100
ASP A 219
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 4.3A)
 0.65A 1rtsA-2aazA:
undetectable		 1rtsA-2aazA:
59.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 7 ILE A 100
ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.59A 1rtsB-2aazA:
undetectable		 1rtsB-2aazA:
59.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 7 ILE A 100
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 1.06A 1rtsB-2aazA:
undetectable		 1rtsB-2aazA:
59.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 12 ILE A 100
TRP A 101
LEU A 184
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.29A 1tlsA-2aazA:
undetectable		 1tlsA-2aazA:
43.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 12 ILE A 100
TRP A 101
LEU A 184
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.32A 1tlsB-2aazA:
undetectable		 1tlsB-2aazA:
43.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 12 ILE A 100
TRP A 101
LEU A 184
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.27A 1tsnA-2aazA:
undetectable		 1tsnA-2aazA:
43.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 12 LEU A 234
ILE A 238
ILE A 241
LEU A 153
LEU A  80
 None
 0.92A 1xdkF-2aazA:
undetectable		 1xdkF-2aazA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 12 HIS A  18
VAL A 224
LEU A  66
THR A  67
THR A  68
 None
 1.09A 1z9yA-2aazA:
undetectable		 1z9yA-2aazA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 12 HIS A  18
PHE A  54
LEU A  66
THR A  67
THR A  68
 None
 0.84A 2aw1A-2aazA:
undetectable		 2aw1A-2aazA:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 12 GLU A  79
TRP A 101
LEU A 184
ASP A 219
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.34A 2kceA-2aazA:
undetectable		 2kceA-2aazA:
43.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 12 TRP A 101
LEU A 184
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.57A 2kceB-2aazA:
undetectable		 2kceB-2aazA:
43.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 7 ILE A 100
ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.69A 2tsrA-2aazA:
undetectable		 2tsrA-2aazA:
59.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 7 ILE A 100
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 1.02A 2tsrA-2aazA:
undetectable		 2tsrA-2aazA:
59.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 8 ILE A 100
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.81A 2tsrB-2aazA:
undetectable		 2tsrB-2aazA:
59.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 8 ILE A 100
TRP A 101
ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.72A 2tsrB-2aazA:
undetectable		 2tsrB-2aazA:
59.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 10 GLU A  79
ILE A 100
TRP A 101
ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.76A 2tsrC-2aazA:
undetectable		 2tsrC-2aazA:
59.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 10 ILE A 100
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.89A 2tsrC-2aazA:
undetectable		 2tsrC-2aazA:
59.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 10 PHE A  72
GLU A  79
ILE A 100
TRP A 101
ASP A 219
GLY A 223
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.80A 2tsrC-2aazA:
undetectable		 2tsrC-2aazA:
59.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 10 PHE A  72
ILE A 100
ASP A 219
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.98A 2tsrC-2aazA:
undetectable		 2tsrC-2aazA:
59.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 9 PHE A  72
ILE A 100
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.97A 2tsrD-2aazA:
undetectable		 2tsrD-2aazA:
59.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 9 PHE A  72
ILE A 100
TRP A 101
ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.77A 2tsrD-2aazA:
undetectable		 2tsrD-2aazA:
59.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 12 ILE A 228
LEU A 251
ILE A 250
PRO A  64
LEU A  58
 None
 1.10A 3a51D-2aazA:
undetectable		 3a51D-2aazA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 12 HIS A  18
ILE A 228
LEU A  66
THR A  67
THR A  68
 None
 0.88A 3fw3A-2aazA:
undetectable		 3fw3A-2aazA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 12 HIS A  18
ILE A 228
LEU A  66
THR A  67
THR A  68
 None
 0.88A 3fw3B-2aazA:
undetectable		 3fw3B-2aazA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 12 GLU A  79
ILE A 100
TRP A 101
LEU A 184
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.29A 3k2hA-2aazA:
undetectable		 3k2hA-2aazA:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 12 GLU A  79
ILE A 100
TRP A 101
LEU A 184
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.30A 3k2hB-2aazA:
undetectable		 3k2hB-2aazA:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 12 GLU A  79
ILE A 100
TRP A 101
ASN A 104
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.47A 3nrrA-2aazA:
undetectable		 3nrrA-2aazA:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 12 GLU A  79
ILE A 100
TRP A 101
ASN A 104
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.49A 3nrrB-2aazA:
undetectable		 3nrrB-2aazA:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 8 VAL A 302
LEU A 280
LEU A  63
ILE A  77
 None
 0.83A 3u5kA-2aazA:
undetectable		 3u5kA-2aazA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 7 VAL A 302
LEU A 280
LEU A  63
ILE A  77
 None
 0.88A 3u5kB-2aazA:
undetectable		 3u5kB-2aazA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 8 VAL A 302
LEU A 280
LEU A  63
ILE A  77
 None
 0.86A 3u5kC-2aazA:
undetectable		 3u5kC-2aazA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 12 LEU A 251
ILE A  27
ARG A  37
ASP A 255
ALA A 256
 None
 1.35A 3uj7A-2aazA:
undetectable		 3uj7A-2aazA:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		9 / 12 ILE A 100
TRP A 101
LEU A 184
HIS A 188
LEU A 222
GLY A 223
PHE A 226
ASN A 227
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
UMP  A 350 (-4.2A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
UMP  A 350 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.46A 3uwlB-2aazA:
undetectable		 3uwlB-2aazA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		8 / 12 TRP A 101
LEU A 184
HIS A 188
LEU A 222
GLY A 223
PHE A 226
ASN A 227
TYR A 259
 CB3  A2351 (-3.7A)
None
UMP  A 350 (-4.2A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
UMP  A 350 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.53A 3uwlD-2aazA:
undetectable		 3uwlD-2aazA:
41.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 5 VAL A 302
LEU A 280
LEU A  63
ILE A  77
 None
 0.82A 4a9jA-2aazA:
undetectable		 4a9jA-2aazA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 5 VAL A 302
LEU A 280
LEU A  63
ILE A  77
 None
 0.85A 4a9jB-2aazA:
undetectable		 4a9jB-2aazA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 5 VAL A 302
LEU A 280
LEU A  63
ILE A  77
 None
 0.83A 4a9jC-2aazA:
undetectable		 4a9jC-2aazA:
15.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 12 ILE A 100
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.88A 4eb4A-2aazA:
undetectable		 4eb4A-2aazA:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 12 ILE A 100
TRP A 101
ASP A 219
GLY A 223
ASN A 227
TYR A 259
MET A 315
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
UMP  A 350 ( 3.2A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.52A 4eb4A-2aazA:
undetectable		 4eb4A-2aazA:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 12 ILE A 100
TRP A 101
ASP A 219
LEU A 222
GLY A 223
TYR A 259
MET A 315
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.60A 4eb4A-2aazA:
undetectable		 4eb4A-2aazA:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 12 PHE A  72
ILE A 100
ASP A 219
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.93A 4eb4A-2aazA:
undetectable		 4eb4A-2aazA:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 12 PHE A  72
ILE A 100
TRP A 101
ASP A 219
GLY A 223
TYR A 259
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.61A 4eb4A-2aazA:
undetectable		 4eb4A-2aazA:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 12 ILE A 100
TRP A 101
ASP A 219
GLY A 223
ASN A 227
TYR A 259
MET A 315
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
UMP  A 350 ( 3.2A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.51A 4eb4B-2aazA:
undetectable		 4eb4B-2aazA:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		8 / 12 PHE A  72
ILE A 100
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.94A 4eb4B-2aazA:
undetectable		 4eb4B-2aazA:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		8 / 12 PHE A  72
ILE A 100
TRP A 101
ASP A 219
LEU A 222
GLY A 223
TYR A 259
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.70A 4eb4B-2aazA:
undetectable		 4eb4B-2aazA:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 9 PHE A  72
ILE A 100
ASP A 219
GLY A 223
ASN A 227
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
UMP  A 350 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.71A 4eb4C-2aazA:
undetectable		 4eb4C-2aazA:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 9 PHE A  72
ILE A 100
ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.79A 4eb4C-2aazA:
undetectable		 4eb4C-2aazA:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 9 PHE A  72
ILE A 100
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 1.12A 4eb4C-2aazA:
undetectable		 4eb4C-2aazA:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 10 ILE A 100
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.99A 4eb4D-2aazA:
undetectable		 4eb4D-2aazA:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 10 ILE A 100
TRP A 101
ASP A 219
GLY A 223
ASN A 227
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
UMP  A 350 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.67A 4eb4D-2aazA:
undetectable		 4eb4D-2aazA:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 10 ILE A 100
TRP A 101
ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.76A 4eb4D-2aazA:
undetectable		 4eb4D-2aazA:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 10 PHE A  72
ILE A 100
ASP A 219
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 1.06A 4eb4D-2aazA:
undetectable		 4eb4D-2aazA:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		8 / 11 LYS A  69
ILE A 100
TRP A 101
LEU A 184
ASP A 219
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 ( 4.1A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.47A 4fogA-2aazA:
undetectable		 4fogA-2aazA:
41.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 11 ILE A 100
TRP A 101
LEU A 184
ASP A 219
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.42A 4fogC-2aazA:
undetectable		 4fogC-2aazA:
41.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		9 / 11 LYS A  69
ILE A 100
TRP A 101
LEU A 184
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 ( 4.1A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.44A 4fogD-2aazA:
undetectable		 4fogD-2aazA:
41.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		9 / 12 GLU A  79
ILE A 100
TRP A 101
LEU A 184
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.34A 4foxA-2aazA:
undetectable		 4foxA-2aazA:
41.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		9 / 12 GLU A  79
ILE A 100
TRP A 101
LEU A 184
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.41A 4foxB-2aazA:
undetectable		 4foxB-2aazA:
41.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		8 / 11 GLU A  79
TRP A 101
LEU A 184
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.43A 4foxC-2aazA:
undetectable		 4foxC-2aazA:
41.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		8 / 12 GLU A  79
ILE A 100
TRP A 101
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.28A 4foxD-2aazA:
undetectable		 4foxD-2aazA:
41.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		9 / 12 LYS A  69
GLU A  79
ILE A 100
TRP A 101
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 ( 4.1A)
CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.41A 4foxE-2aazA:
undetectable		 4foxE-2aazA:
41.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		8 / 11 GLU A  79
ILE A 100
TRP A 101
LEU A 184
ASP A 219
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.29A 4foxF-2aazA:
undetectable		 4foxF-2aazA:
41.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		9 / 12 GLU A  79
ILE A 100
TRP A 101
LEU A 184
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.31A 4foxG-2aazA:
undetectable		 4foxG-2aazA:
41.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 11 GLU A  79
ILE A 100
TRP A 101
ASP A 219
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.25A 4foxH-2aazA:
undetectable		 4foxH-2aazA:
41.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		8 / 12 GLU A  79
ILE A 100
TRP A 101
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.21A 4fqsA-2aazA:
undetectable		 4fqsA-2aazA:
41.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		8 / 12 GLU A  79
ILE A 100
TRP A 101
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.23A 4fqsB-2aazA:
undetectable		 4fqsB-2aazA:
41.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 11 ILE A  77
ALA A 232
LEU A 233
LEU A  73
TYR A 305
 None
 1.07A 4g1bB-2aazA:
undetectable		 4g1bB-2aazA:
22.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 7 ILE A 100
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 1.02A 4iqqA-2aazA:
undetectable		 4iqqA-2aazA:
49.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 7 ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.75A 4iqqB-2aazA:
undetectable		 4iqqB-2aazA:
49.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 7 ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.65A 4iqqC-2aazA:
undetectable		 4iqqC-2aazA:
49.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 8 ILE A 100
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 1.06A 4iqqD-2aazA:
undetectable		 4iqqD-2aazA:
49.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 8 LYS A  69
ILE A 100
ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 ( 4.1A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 1.12A 4iqqD-2aazA:
undetectable		 4iqqD-2aazA:
49.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 9 CYH A 191
HIS A 188
ILE A 238
MET A 237
 None
UMP  A 350 (-4.2A)
None
None
 1.14A 4jvlA-2aazA:
undetectable		 4jvlA-2aazA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 6 LEU A 270
ARG A  13
GLU A  20
VAL A 224
 None
 1.01A 4nkxA-2aazA:
undetectable		 4nkxA-2aazA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		3 / 3 PRO A 265
VAL A 258
HIS A 257
 None
None
UMP  A 350 (-4.0A)
 0.76A 4pevC-2aazA:
undetectable		 4pevC-2aazA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 6 TRP A 282
GLY A 290
PHE A 295
ILE A 292
 None
 1.05A 4qogA-2aazA:
undetectable
4qogB-2aazA:
undetectable		 4qogA-2aazA:
21.94
4qogB-2aazA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 8 LEU A 280
VAL A 302
ALA A 232
HIS A  18
 None
 0.83A 4qrcA-2aazA:
undetectable		 4qrcA-2aazA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 5 ALA A 239
THR A 242
VAL A 156
ILE A 157
 None
 0.83A 4xe3A-2aazA:
undetectable		 4xe3A-2aazA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 5 ALA A 239
THR A 242
VAL A 156
ILE A 157
 None
 0.79A 4xe3B-2aazA:
undetectable		 4xe3B-2aazA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 8 LEU A 110
VAL A 113
ALA A 183
LEU A 123
GLY A 103
 None
 1.27A 4zauA-2aazA:
undetectable		 4zauA-2aazA:
21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 11 PHE A  72
ILE A 100
TRP A 101
ASN A 104
LEU A 184
ASP A 219
LEU A 222
GLY A 223
TYR A 259
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.59A 5fctA-2aazA:
undetectable		 5fctA-2aazA:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		11 / 12 LYS A  69
VAL A  71
PHE A  72
ILE A 100
TRP A 101
LEU A 184
CYH A 187
LEU A 222
TYR A 259
MET A 313
MET A 315
 CB3  A2351 ( 4.1A)
None
CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
UMP  A 350 (-1.8A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 4.3A)
None
CB3  A2351 (-3.4A)
 0.37A 5fctB-2aazA:
undetectable		 5fctB-2aazA:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		3 / 3 ASN A 104
ASP A 219
GLY A 223
 CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
 0.21A 5fctB-2aazA:
undetectable		 5fctB-2aazA:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_A_D16A401_1
(ORF70)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 7 PHE A  72
ILE A 100
ASP A 219
GLY A 223
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.76A 5h3aA-2aazA:
undetectable		 5h3aA-2aazA:
59.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_A_D16A401_1
(ORF70)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 7 PHE A  72
ILE A 100
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 1.20A 5h3aA-2aazA:
undetectable		 5h3aA-2aazA:
59.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_B_D16B401_1
(ORF70)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 7 ILE A 100
ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.78A 5h3aB-2aazA:
undetectable		 5h3aB-2aazA:
59.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_B_D16B401_1
(ORF70)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 7 ILE A 100
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 1.12A 5h3aB-2aazA:
undetectable		 5h3aB-2aazA:
59.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_B_D16B401_1
(ORF70)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 7 PHE A  72
ASP A 219
GLY A 223
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.53A 5h3aB-2aazA:
undetectable		 5h3aB-2aazA:
59.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 11 LEU A  24
GLU A  20
LEU A  66
MET A 313
HIS A 262
 None
 1.48A 5hyrB-2aazA:
undetectable		 5hyrB-2aazA:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		8 / 12 GLU A  79
ILE A 100
LEU A 184
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.35A 5j7wC-2aazA:
undetectable		 5j7wC-2aazA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		9 / 12 GLU A  79
ILE A 100
TRP A 101
LEU A 184
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.41A 5j7wD-2aazA:
undetectable		 5j7wD-2aazA:
41.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 7 HIS A  18
LEU A  66
THR A  67
THR A  68
 None
 0.84A 5m78A-2aazA:
undetectable		 5m78A-2aazA:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 7 ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.76A 5nooA-2aazA:
undetectable		 5nooA-2aazA:
49.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 7 ILE A 100
ASP A 219
GLY A 223
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.59A 5nooA-2aazA:
undetectable		 5nooA-2aazA:
49.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 7 ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.76A 5nooB-2aazA:
undetectable		 5nooB-2aazA:
49.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 6 ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.76A 5nooC-2aazA:
undetectable		 5nooC-2aazA:
49.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 6 LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 1.03A 5nooC-2aazA:
undetectable		 5nooC-2aazA:
49.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 8 ARG A  70
ILE A 100
ASP A 219
LEU A 222
GLY A 223
TYR A 259
 None
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 1.38A 5nooD-2aazA:
undetectable		 5nooD-2aazA:
49.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 8 ILE A 100
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 1.14A 5nooD-2aazA:
undetectable		 5nooD-2aazA:
49.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		8 / 12 GLU A  79
ILE A 100
TRP A 101
ASP A 219
LEU A 222
GLY A 223
TYR A 259
MET A 313
 CB3  A2351 (-3.2A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
None
 0.66A 5x5qB-2aazA:
undetectable		 5x5qB-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 12 ILE A 100
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.97A 5x5qB-2aazA:
undetectable		 5x5qB-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		8 / 12 ILE A 100
TRP A 101
ASP A 219
LEU A 222
GLY A 223
TYR A 259
MET A 313
MET A 315
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
None
CB3  A2351 (-3.4A)
 0.76A 5x5qB-2aazA:
undetectable		 5x5qB-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 7 ILE A 100
ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.68A 5x5qC-2aazA:
undetectable		 5x5qC-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 7 PHE A  72
ILE A 100
ASP A 219
GLY A 223
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.68A 5x5qC-2aazA:
undetectable		 5x5qC-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 8 ILE A 100
ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.65A 5x5qD-2aazA:
undetectable		 5x5qD-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 8 ILE A 100
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 1.02A 5x5qD-2aazA:
undetectable		 5x5qD-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 8 PHE A  72
ILE A 100
ASP A 219
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 4.3A)
 0.62A 5x5qD-2aazA:
undetectable		 5x5qD-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 6 PHE A  72
ILE A 100
ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.73A 5x5qE-2aazA:
undetectable		 5x5qE-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 8 ILE A 100
ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.65A 5x5qF-2aazA:
undetectable		 5x5qF-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 8 ILE A 100
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 1.02A 5x5qF-2aazA:
undetectable		 5x5qF-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 8 PHE A  72
ILE A 100
ASP A 219
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 4.3A)
 0.61A 5x5qF-2aazA:
undetectable		 5x5qF-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 12 ILE A 100
ASP A 219
LEU A 222
GLY A 223
ASN A 227
TYR A 259
MET A 315
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
UMP  A 350 ( 3.2A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.58A 5x66A-2aazA:
undetectable
5x66B-2aazA:
undetectable		 5x66A-2aazA:
61.84
5x66B-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 12 PHE A  72
ILE A 100
ASP A 219
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 1.06A 5x66A-2aazA:
undetectable
5x66B-2aazA:
undetectable		 5x66A-2aazA:
61.84
5x66B-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 12 PHE A  72
ILE A 100
ASP A 219
LEU A 222
GLY A 223
TYR A 259
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.69A 5x66A-2aazA:
undetectable
5x66B-2aazA:
undetectable		 5x66A-2aazA:
61.84
5x66B-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 9 ILE A 100
ASP A 219
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 1.01A 5x66C-2aazA:
undetectable		 5x66C-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 9 ILE A 100
ASP A 219
LEU A 222
GLY A 223
ASN A 227
TYR A 259
MET A 315
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
UMP  A 350 ( 3.2A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.56A 5x66C-2aazA:
undetectable		 5x66C-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 10 ARG A  70
ASP A 219
PHE A 226
TYR A 259
MET A 315
 None
CB3  A2351 ( 3.6A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 1.29A 5x66D-2aazA:
undetectable		 5x66D-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		6 / 10 ILE A 100
ASP A 219
GLY A 223
ASN A 227
TYR A 259
MET A 315
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
UMP  A 350 ( 3.2A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.53A 5x66D-2aazA:
undetectable		 5x66D-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 10 PHE A  72
ILE A 100
ASP A 219
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 1.02A 5x66D-2aazA:
undetectable		 5x66D-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		8 / 12 LYS A  69
PHE A  72
ILE A 100
ASP A 219
LEU A 222
GLY A 223
TYR A 259
MET A 315
 CB3  A2351 ( 4.1A)
CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.64A 5x66F-2aazA:
undetectable		 5x66F-2aazA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 12 PHE A  72
ILE A 100
ASP A 219
GLY A 223
PHE A 226
TYR A 259
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 1.03A 5x66F-2aazA:
undetectable		 5x66F-2aazA:
61.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 6 GLY A 124
THR A  88
TYR A 145
TYR A 138
 None
 1.30A 6ag0A-2aazA:
undetectable		 6ag0A-2aazA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 6 GLN A  22
LEU A  66
ARG A 272
PRO A 274
 None
 1.09A 6brdB-2aazA:
undetectable		 6brdB-2aazA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		4 / 4 LEU A 153
ASP A 151
GLN A 154
VAL A 301
 None
 1.42A 6bzoF-2aazA:
undetectable		 6bzoF-2aazA:
18.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		8 / 12 ILE A 100
TRP A 101
LEU A 184
LEU A 222
GLY A 223
PHE A 226
ASN A 227
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
UMP  A 350 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.46A 6qxsB-2aazA:
undetectable		 6qxsB-2aazA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		7 / 12 ILE A 100
TRP A 101
LEU A 184
ASP A 219
LEU A 222
GLY A 223
ASN A 227
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
UMP  A 350 ( 3.2A)
 0.50A 6qxsD-2aazA:
undetectable		 6qxsD-2aazA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		8 / 12 ILE A 100
TRP A 101
LEU A 184
HIS A 188
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
UMP  A 350 (-4.2A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.44A 6qyaB-2aazA:
undetectable		 6qyaB-2aazA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		9 / 12 ILE A 100
TRP A 101
LEU A 184
HIS A 188
LEU A 222
GLY A 223
PHE A 226
ASN A 227
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
UMP  A 350 (-4.2A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
UMP  A 350 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.44A 6qyaD-2aazA:
undetectable		 6qyaD-2aazA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		12 / 12 PHE A  72
ILE A 100
TRP A 101
ASN A 104
LEU A 184
ASP A 219
LEU A 222
GLY A 223
PHE A 226
ASN A 227
TYR A 259
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
UMP  A 350 ( 3.2A)
CB3  A2351 ( 4.3A)
CB3  A2351 (-3.4A)
 0.56A 6r2eA-2aazA:
undetectable		 6r2eA-2aazA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 10 PHE A  72
ILE A 100
TRP A 101
ASN A 104
LEU A 184
ASP A 219
LEU A 222
GLY A 223
ASN A 227
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
UMP  A 350 ( 3.2A)
CB3  A2351 (-3.4A)
 0.54A 6r2eB-2aazA:
undetectable		 6r2eB-2aazA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 10 PHE A  72
ILE A 100
TRP A 101
ASN A 104
LEU A 184
ASP A 219
LEU A 222
GLY A 223
ASN A 227
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
UMP  A 350 ( 3.2A)
CB3  A2351 (-3.4A)
 0.57A 6r2eC-2aazA:
undetectable		 6r2eC-2aazA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 10 PHE A  72
ILE A 100
TRP A 101
ASN A 104
LEU A 184
ASP A 219
LEU A 222
GLY A 223
ASN A 227
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
UMP  A 350 ( 3.2A)
CB3  A2351 (-3.4A)
 0.51A 6r2eD-2aazA:
undetectable		 6r2eD-2aazA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		11 / 12 PHE A  72
ILE A 100
TRP A 101
ASN A 104
TYR A 127
LEU A 184
LEU A 222
GLY A 223
PHE A 226
ASN A 227
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
None
None
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
UMP  A 350 ( 3.2A)
CB3  A2351 (-3.4A)
 0.47A 6r2eE-2aazA:
undetectable		 6r2eE-2aazA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		5 / 12 PHE A  72
ILE A 100
TYR A 127
PHE A 226
ALA A 317
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
None
CB3  A2351 (-3.8A)
None
 1.04A 6r2eE-2aazA:
undetectable		 6r2eE-2aazA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		10 / 11 PHE A  72
ILE A 100
TRP A 101
ASN A 104
LEU A 184
ASP A 219
LEU A 222
GLY A 223
ASN A 227
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
UMP  A 350 ( 3.2A)
CB3  A2351 (-3.4A)
 0.49A 6r2eF-2aazA:
undetectable		 6r2eF-2aazA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		11 / 11 PHE A  72
ILE A 100
TRP A 101
ASN A 104
LEU A 184
ASP A 219
LEU A 222
GLY A 223
PHE A 226
ASN A 227
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
UMP  A 350 ( 3.2A)
CB3  A2351 (-3.4A)
 0.50A 6r2eG-2aazA:
undetectable		 6r2eG-2aazA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 2aaz THYMIDYLATE SYNTHASE
(Cryptococcus
neoformans) 		11 / 12 PHE A  72
ILE A 100
TRP A 101
ASN A 104
TYR A 127
LEU A 184
ASP A 219
LEU A 222
GLY A 223
ASN A 227
MET A 315
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 (-3.7A)
None
None
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
UMP  A 350 ( 3.2A)
CB3  A2351 (-3.4A)
 0.64A 6r2eH-2aazA:
undetectable		 6r2eH-2aazA:
56.34