SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ab4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 2ab4 TRNA PSEUDOURIDINE
SYNTHASE B
(Thermotoga
maritima) 		4 / 7 VAL A  69
SER A 160
ASN A 153
ASP A 151
 None
 1.28A 1hwiC-2ab4A:
3.4		 1hwiC-2ab4A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 2ab4 TRNA PSEUDOURIDINE
SYNTHASE B
(Thermotoga
maritima) 		4 / 7 VAL A  69
SER A 160
ASN A 153
ASP A 151
 None
 1.28A 1hwiD-2ab4A:
3.4		 1hwiD-2ab4A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 2ab4 TRNA PSEUDOURIDINE
SYNTHASE B
(Thermotoga
maritima) 		3 / 3 LEU A 130
LEU A 127
SER A 118
 None
 0.60A 1tlmA-2ab4A:
undetectable		 1tlmA-2ab4A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2ab4 TRNA PSEUDOURIDINE
SYNTHASE B
(Thermotoga
maritima) 		3 / 3 ARG A 218
VAL A  19
GLY A  36
 None
None
U  B   9 ( 3.3A)
 0.62A 2avvE-2ab4A:
undetectable		 2avvE-2ab4A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 2ab4 TRNA PSEUDOURIDINE
SYNTHASE B
(Thermotoga
maritima) 		4 / 8 ASP A  81
ARG A 157
LEU A  75
GLU A  89
 C  B  11 ( 2.8A)
None
None
None
 0.92A 2cdqA-2ab4A:
undetectable		 2cdqA-2ab4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 2ab4 TRNA PSEUDOURIDINE
SYNTHASE B
(Thermotoga
maritima) 		4 / 7 ASP A  81
ARG A 157
LEU A  75
GLU A  89
 C  B  11 ( 2.8A)
None
None
None
 0.86A 2cdqB-2ab4A:
undetectable		 2cdqB-2ab4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 2ab4 TRNA PSEUDOURIDINE
SYNTHASE B
(Thermotoga
maritima) 		4 / 9 ILE A 171
PHE A 161
VAL A  69
GLU A 190
 None
 0.86A 2vufA-2ab4A:
undetectable		 2vufA-2ab4A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 2ab4 TRNA PSEUDOURIDINE
SYNTHASE B
(Thermotoga
maritima) 		6 / 10 LEU A  46
GLY A  33
ILE A  56
GLY A   4
ILE A 219
ILE A  47
 None
C  B  16 ( 3.5A)
None
None
None
None
 1.43A 3ekpD-2ab4A:
undetectable		 3ekpD-2ab4A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2ab4 TRNA PSEUDOURIDINE
SYNTHASE B
(Thermotoga
maritima) 		4 / 5 VAL A  20
VAL A  23
ARG A  24
LYS A   1
 None
None
U  B  15 ( 3.4A)
None
 0.61A 3rv5A-2ab4A:
0.0
3rv5B-2ab4A:
undetectable		 3rv5A-2ab4A:
13.92
3rv5B-2ab4A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 2ab4 TRNA PSEUDOURIDINE
SYNTHASE B
(Thermotoga
maritima) 		6 / 12 LEU A  46
GLY A  33
ILE A  56
GLY A   4
ILE A 219
ILE A  47
 None
C  B  16 ( 3.5A)
None
None
None
None
 1.45A 3tl9B-2ab4A:
undetectable		 3tl9B-2ab4A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 2ab4 TRNA PSEUDOURIDINE
SYNTHASE B
(Thermotoga
maritima) 		4 / 6 GLU A 125
GLY A 124
LEU A 130
TYR A 122
 None
G  B   7 ( 2.9A)
None
None
 0.91A 3w9tB-2ab4A:
undetectable		 3w9tB-2ab4A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 2ab4 TRNA PSEUDOURIDINE
SYNTHASE B
(Thermotoga
maritima) 		4 / 6 GLU A 125
GLY A 124
LEU A 130
TYR A 122
 None
G  B   7 ( 2.9A)
None
None
 0.91A 3w9tE-2ab4A:
undetectable		 3w9tE-2ab4A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2ab4 TRNA PSEUDOURIDINE
SYNTHASE B
(Thermotoga
maritima) 		4 / 6 MET A 176
GLY A 179
GLU A  88
ARG A  90
 None
 1.32A 4bqfA-2ab4A:
undetectable		 4bqfA-2ab4A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 2ab4 TRNA PSEUDOURIDINE
SYNTHASE B
(Thermotoga
maritima) 		3 / 3 LEU A 243
LYS A 240
THR A 239
 None
 0.52A 4lj0A-2ab4A:
undetectable		 4lj0A-2ab4A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2ab4 TRNA PSEUDOURIDINE
SYNTHASE B
(Thermotoga
maritima) 		3 / 4 ARG A  72
GLY A  74
GLU A  89
 None
 0.57A 4z2dB-2ab4A:
undetectable
4z2dC-2ab4A:
undetectable		 4z2dB-2ab4A:
22.64
4z2dC-2ab4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2ab4 TRNA PSEUDOURIDINE
SYNTHASE B
(Thermotoga
maritima) 		4 / 4 LEU A 253
MET A 252
VAL A 234
ASN A 269
 None
 1.43A 5b8iB-2ab4A:
undetectable		 5b8iB-2ab4A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2ab4 TRNA PSEUDOURIDINE
SYNTHASE B
(Thermotoga
maritima) 		5 / 12 ILE A   5
GLY A  49
TYR A  60
HIS A 199
ARG A 193
 None
 1.27A 5igwA-2ab4A:
undetectable		 5igwA-2ab4A:
24.46