SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ab5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 2ab5 MRNA MATURASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 291
GLY A 313
ILE A 344
ILE A 345
 None
SO4  A 605 (-3.3A)
None
None
 0.80A 2q9rA-2ab5A:
undetectable		 2q9rA-2ab5A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2ab5 MRNA MATURASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 418
ILE A 504
TYR A 507
ILE A 472
 None
 0.73A 3uqbA-2ab5A:
undetectable		 3uqbA-2ab5A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2ab5 MRNA MATURASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 336
THR A 279
TRP A 277
 None
 1.00A 4d7hA-2ab5A:
undetectable		 4d7hA-2ab5A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2ab5 MRNA MATURASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 336
THR A 279
TRP A 277
 None
 0.94A 4ug5A-2ab5A:
0.0		 4ug5A-2ab5A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 2ab5 MRNA MATURASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 336
THR A 279
TRP A 277
 None
 0.99A 4uglA-2ab5A:
undetectable		 4uglA-2ab5A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 2ab5 MRNA MATURASE
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 264
ILE A 306
TYR A 267
GLU A 410
 None
 1.28A 4zzcE-2ab5A:
undetectable		 4zzcE-2ab5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2ab5 MRNA MATURASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 336
THR A 279
TRP A 277
 None
 0.93A 5g6cA-2ab5A:
undetectable		 5g6cA-2ab5A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2ab5 MRNA MATURASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 298
LYS A 490
ARG A 502
 SO4  A 603 (-3.8A)
None
None
 1.12A 6c06D-2ab5A:
undetectable		 6c06D-2ab5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 2ab5 MRNA MATURASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 440
GLY A 270
GLY A 407
ILE A 406
ILE A 444
 None
 0.89A 6dj1A-2ab5A:
undetectable		 6dj1A-2ab5A:
13.57