SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2abj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		5 / 12 ALA A 163
PHE A 164
LEU A 108
LEU A 135
LEU A 185
 None
 0.99A 1eiiA-2abjA:
undetectable		 1eiiA-2abjA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 6 LEU A 244
ASP A 235
MET A 326
LEU A 318
 None
 1.22A 1errB-2abjA:
undetectable		 1errB-2abjA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		5 / 12 SER A 157
TYR A 372
GLY A 189
PRO A 190
PHE A 192
 None
 1.40A 1fdsA-2abjA:
undetectable		 1fdsA-2abjA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 7 LEU A  96
MET A 115
LEU A 135
GLN A 140
 None
 1.10A 1kt3A-2abjA:
undetectable		 1kt3A-2abjA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 7 PHE A 197
ALA A 360
PRO A 357
GLU A 325
 None
 1.05A 1oniA-2abjA:
undetectable
1oniB-2abjA:
undetectable		 1oniA-2abjA:
20.86
1oniB-2abjA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 7 PRO A 357
GLU A 325
PHE A 197
ALA A 360
 None
 1.11A 1oniG-2abjA:
undetectable
1oniI-2abjA:
undetectable		 1oniG-2abjA:
20.86
1oniI-2abjA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 7 PHE A 130
LEU A 181
THR A  22
LYS A  24
 None
 1.23A 1rmtB-2abjA:
undetectable		 1rmtB-2abjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		5 / 12 ILE A 292
ALA A 296
GLN A 298
VAL A 335
LEU A 359
 None
 0.96A 1xdkE-2abjA:
undetectable		 1xdkE-2abjA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		5 / 12 ILE A 292
ALA A 296
GLN A 298
VAL A 335
LEU A 359
 None
 1.06A 1xiuB-2abjA:
undetectable		 1xiuB-2abjA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 4 LEU A 261
PRO A 206
ILE A 341
LEU A 202
 None
 1.04A 1ya4B-2abjA:
undetectable		 1ya4B-2abjA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 4 LEU A 261
PRO A 206
ILE A 341
LEU A 202
 None
 1.10A 1ya4C-2abjA:
undetectable		 1ya4C-2abjA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		6 / 8 TYR A 159
ARG A 161
THR A 258
GLY A 330
THR A 331
ALA A 332
 CBC  A1401 (-4.3A)
CBC  A1401 ( 4.8A)
CBC  A1401 ( 3.8A)
CBC  A1401 ( 3.4A)
PLP  A 420 ( 3.6A)
CBC  A1401 (-3.3A)
 0.37A 2a1hA-2abjA:
54.5
2a1hB-2abjA:
54.5		 2a1hA-2abjA:
57.65
2a1hB-2abjA:
57.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		6 / 8 TYR A 159
ARG A 161
THR A 258
GLY A 330
THR A 331
ALA A 332
 CBC  A1401 (-4.3A)
CBC  A1401 ( 4.8A)
CBC  A1401 ( 3.8A)
CBC  A1401 ( 3.4A)
PLP  A 420 ( 3.6A)
CBC  A1401 (-3.3A)
 0.40A 2a1hA-2abjA:
54.5
2a1hB-2abjA:
54.5		 2a1hA-2abjA:
57.65
2a1hB-2abjA:
57.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		7 / 10 TYR A 159
ARG A 161
THR A 258
MET A 259
GLY A 330
THR A 331
ALA A 332
 CBC  A1401 (-4.3A)
CBC  A1401 ( 4.8A)
CBC  A1401 ( 3.8A)
CBC  A1401 (-3.3A)
CBC  A1401 ( 3.4A)
PLP  A 420 ( 3.6A)
CBC  A1401 (-3.3A)
 0.46A 2coiA-2abjA:
57.1
2coiB-2abjA:
57.0		 2coiA-2abjA:
98.63
2coiB-2abjA:
98.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		6 / 10 TYR A 159
TYR A 191
MET A 259
GLY A 330
THR A 331
ALA A 332
 CBC  A1401 (-4.3A)
CBC  A1401 (-4.1A)
CBC  A1401 (-3.3A)
CBC  A1401 ( 3.4A)
PLP  A 420 ( 3.6A)
CBC  A1401 (-3.3A)
 1.09A 2coiA-2abjA:
57.1
2coiB-2abjA:
57.0		 2coiA-2abjA:
98.63
2coiB-2abjA:
98.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		7 / 10 TYR A 159
ARG A 161
THR A 258
MET A 259
GLY A 330
THR A 331
ALA A 332
 CBC  A1401 (-4.3A)
CBC  A1401 ( 4.8A)
CBC  A1401 ( 3.8A)
CBC  A1401 (-3.3A)
CBC  A1401 ( 3.4A)
PLP  A 420 ( 3.6A)
CBC  A1401 (-3.3A)
 0.43A 2coiA-2abjA:
57.1
2coiB-2abjA:
57.0		 2coiA-2abjA:
98.63
2coiB-2abjA:
98.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		5 / 10 TYR A 159
TYR A 191
GLY A 330
THR A 331
ALA A 332
 CBC  A1401 (-4.3A)
CBC  A1401 (-4.1A)
CBC  A1401 ( 3.4A)
PLP  A 420 ( 3.6A)
CBC  A1401 (-3.3A)
 0.96A 2coiA-2abjA:
57.1
2coiB-2abjA:
57.0		 2coiA-2abjA:
98.63
2coiB-2abjA:
98.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		8 / 11 PHE A  93
TYR A 159
ARG A 161
THR A 258
MET A 259
GLY A 330
THR A 331
ALA A 332
 CBC  A1401 (-4.6A)
CBC  A1401 (-4.3A)
CBC  A1401 ( 4.8A)
CBC  A1401 ( 3.8A)
CBC  A1401 (-3.3A)
CBC  A1401 ( 3.4A)
PLP  A 420 ( 3.6A)
CBC  A1401 (-3.3A)
 0.43A 2cojA-2abjA:
56.8
2cojB-2abjA:
56.8		 2cojA-2abjA:
98.63
2cojB-2abjA:
98.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		7 / 9 TYR A 159
ARG A 161
THR A 258
MET A 259
GLY A 330
THR A 331
ALA A 332
 CBC  A1401 (-4.3A)
CBC  A1401 ( 4.8A)
CBC  A1401 ( 3.8A)
CBC  A1401 (-3.3A)
CBC  A1401 ( 3.4A)
PLP  A 420 ( 3.6A)
CBC  A1401 (-3.3A)
 0.50A 2cojA-2abjA:
56.8
2cojB-2abjA:
56.8		 2cojA-2abjA:
98.63
2cojB-2abjA:
98.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		5 / 8 TYR A 159
ARG A 161
GLY A 330
THR A 331
ALA A 332
 CBC  A1401 (-4.3A)
CBC  A1401 ( 4.8A)
CBC  A1401 ( 3.4A)
PLP  A 420 ( 3.6A)
CBC  A1401 (-3.3A)
 0.33A 2ej3A-2abjA:
31.2		 2ej3A-2abjA:
28.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		7 / 10 PHE A  93
TYR A 159
ARG A 161
TYR A 225
GLY A 330
THR A 331
ALA A 332
 CBC  A1401 (-4.6A)
CBC  A1401 (-4.3A)
CBC  A1401 ( 4.8A)
PLP  A 420 (-4.4A)
CBC  A1401 ( 3.4A)
PLP  A 420 ( 3.6A)
CBC  A1401 (-3.3A)
 0.29A 2ej3B-2abjA:
31.7		 2ej3B-2abjA:
28.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		5 / 8 TYR A 159
ARG A 161
GLY A 330
THR A 331
ALA A 332
 CBC  A1401 (-4.3A)
CBC  A1401 ( 4.8A)
CBC  A1401 ( 3.4A)
PLP  A 420 ( 3.6A)
CBC  A1401 (-3.3A)
 0.33A 2ej3C-2abjA:
30.9		 2ej3C-2abjA:
28.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		5 / 7 ILE A 363
ARG A 362
TYR A 264
PHE A 302
GLU A 301
 None
 0.98A 2qebA-2abjA:
undetectable		 2qebA-2abjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		5 / 7 ILE A 363
ARG A 362
TYR A 264
PHE A 302
GLU A 301
 None
 1.00A 2qebB-2abjA:
undetectable		 2qebB-2abjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 6 ASP A 340
ILE A 350
LEU A 318
GLU A 354
 None
 0.95A 2ya7A-2abjA:
1.3		 2ya7A-2abjA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 6 ASP A 340
ILE A 350
LEU A 318
GLU A 354
 None
 0.93A 2ya7B-2abjA:
1.3		 2ya7B-2abjA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 6 ASP A 340
ILE A 350
LEU A 318
GLU A 354
 None
 0.96A 2ya7D-2abjA:
undetectable		 2ya7D-2abjA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		3 / 3 LEU A 135
TRP A  60
TYR A 119
 None
 0.83A 3aicA-2abjA:
undetectable		 3aicA-2abjA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		3 / 3 LEU A 135
TRP A  60
TYR A 119
 None
 0.78A 3aicB-2abjA:
undetectable		 3aicB-2abjA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		3 / 3 LEU A 135
TRP A  60
TYR A 119
 None
 0.79A 3aicE-2abjA:
undetectable		 3aicE-2abjA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		3 / 3 LEU A 135
TRP A  60
TYR A 119
 None
 0.88A 3aicF-2abjA:
undetectable		 3aicF-2abjA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		3 / 3 LEU A 135
TRP A  60
TYR A 119
 None
 0.82A 3aicG-2abjA:
undetectable		 3aicG-2abjA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		3 / 3 LEU A 135
TRP A  60
TYR A 119
 None
 0.77A 3aicH-2abjA:
undetectable		 3aicH-2abjA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 8 TYR A 308
LEU A 309
THR A 310
ILE A 282
 None
 0.78A 3jusA-2abjA:
undetectable		 3jusA-2abjA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 8 TYR A 308
LEU A 309
THR A 310
ILE A 282
 None
 0.78A 3jusA-2abjA:
undetectable		 3jusA-2abjA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 8 TYR A 308
LEU A 309
THR A 310
ILE A 282
 None
 0.73A 3jusB-2abjA:
undetectable		 3jusB-2abjA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 5 TYR A 372
GLN A 371
ILE A 292
LEU A 367
 None
 1.23A 3ls4L-2abjA:
undetectable		 3ls4L-2abjA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		3 / 4 SER A 121
GLY A 286
GLU A 306
 None
PLP  A 420 (-3.3A)
None
 0.68A 3raeA-2abjA:
undetectable
3raeC-2abjA:
undetectable		 3raeA-2abjA:
20.98
3raeC-2abjA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 6 MET A 326
LEU A 263
GLN A 252
PRO A 277
 None
 1.46A 3vkxA-2abjA:
undetectable		 3vkxA-2abjA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 6 SER A 227
GLY A 281
ASP A 218
GLY A 214
 None
 0.82A 4koeA-2abjA:
0.0
4koeB-2abjA:
0.0
4koeC-2abjA:
undetectable		 4koeA-2abjA:
20.98
4koeB-2abjA:
20.98
4koeC-2abjA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 6 GLY A 281
ASP A 218
GLY A 214
SER A 227
 None
 0.83A 4z53A-2abjA:
undetectable
4z53B-2abjA:
undetectable		 4z53A-2abjA:
19.64
4z53B-2abjA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		3 / 3 VAL A 102
THR A 154
ARG A 374
 None
 0.66A 5b2sB-2abjA:
undetectable		 5b2sB-2abjA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		3 / 3 VAL A 102
THR A 154
ARG A 374
 None
 0.70A 5b2tB-2abjA:
undetectable		 5b2tB-2abjA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		5 / 10 LEU A 261
VAL A 323
ILE A 348
LEU A 318
LEU A 246
 None
 1.18A 5ienB-2abjA:
undetectable		 5ienB-2abjA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 7 GLY A 330
SER A 329
LEU A 367
GLU A  94
 CBC  A1401 ( 3.4A)
None
None
None
 0.75A 5izfA-2abjA:
undetectable		 5izfA-2abjA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 8 THR A 154
PHE A 192
PRO A 190
TYR A 372
 None
 1.10A 5v4vA-2abjA:
undetectable		 5v4vA-2abjA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 8 THR A 154
PHE A 192
PRO A 190
TYR A 372
 None
 1.13A 5v4vB-2abjA:
undetectable		 5v4vB-2abjA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 7 HIS A 297
ARG A 290
GLU A 306
ARG A 289
 None
 1.29A 6b8kA-2abjA:
undetectable		 6b8kA-2abjA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		5 / 12 LEU A 309
GLU A 306
PRO A 277
TRP A 212
GLY A 217
 None
 1.43A 6mn8A-2abjA:
undetectable		 6mn8A-2abjA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 7 GLY A  48
TYR A 159
GLU A  94
GLY A  95
 None
CBC  A1401 (-4.3A)
None
None
 0.95A 6n7fA-2abjA:
undetectable		 6n7fA-2abjA:
12.36