SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2acg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2acg PROFILIN II
(Acanthamoeba
castellanii) 		3 / 3 ILE A  97
ILE A  95
THR A  31
 None
 0.64A 1rg7A-2acgA:
undetectable		 1rg7A-2acgA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2acg PROFILIN II
(Acanthamoeba
castellanii) 		4 / 8 GLY A 107
THR A 108
ALA A 109
ALA A 110
 None
 0.56A 2ej3A-2acgA:
undetectable		 2ej3A-2acgA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2acg PROFILIN II
(Acanthamoeba
castellanii) 		4 / 7 GLU A  61
GLN A  18
ALA A 109
ILE A 104
 None
 0.69A 2xkwA-2acgA:
undetectable		 2xkwA-2acgA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 2acg PROFILIN II
(Acanthamoeba
castellanii) 		4 / 5 VAL A 112
VAL A 113
THR A   8
THR A 108
 None
 1.27A 3bjwG-2acgA:
undetectable		 3bjwG-2acgA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 2acg PROFILIN II
(Acanthamoeba
castellanii) 		4 / 5 VAL A 112
VAL A 113
THR A   8
THR A 108
 None
 1.26A 3bjwD-2acgA:
undetectable		 3bjwD-2acgA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2acg PROFILIN II
(Acanthamoeba
castellanii) 		5 / 12 ILE A  97
LEU A  96
LEU A  10
THR A  69
VAL A 113
 None
 1.28A 3dcjA-2acgA:
undetectable
3dcjB-2acgA:
undetectable		 3dcjA-2acgA:
22.33
3dcjB-2acgA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 2acg PROFILIN II
(Acanthamoeba
castellanii) 		4 / 8 ALA A  54
ILE A  55
ASN A  58
ARG A  66
 None
 0.99A 3fxrA-2acgA:
undetectable		 3fxrA-2acgA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2acg PROFILIN II
(Acanthamoeba
castellanii) 		5 / 12 GLY A  98
GLY A  79
LYS A  81
ALA A  84
PHE A  60
 None
 1.30A 3qowA-2acgA:
undetectable		 3qowA-2acgA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2acg PROFILIN II
(Acanthamoeba
castellanii) 		5 / 12 PHE A  60
SER A  57
ASP A  51
ALA A  44
PHE A  49
 None
 1.14A 4dx5B-2acgA:
undetectable		 4dx5B-2acgA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 2acg PROFILIN II
(Acanthamoeba
castellanii) 		4 / 6 TRP A   2
ASN A   9
TYR A 119
LEU A 120
 None
 1.25A 4f8yA-2acgA:
undetectable
4f8yB-2acgA:
undetectable		 4f8yA-2acgA:
23.24
4f8yB-2acgA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 2acg PROFILIN II
(Acanthamoeba
castellanii) 		4 / 7 TYR A 119
LEU A 120
TRP A   2
ASN A   9
 None
 1.28A 4f8yC-2acgA:
undetectable
4f8yD-2acgA:
undetectable		 4f8yC-2acgA:
23.24
4f8yD-2acgA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2acg PROFILIN II
(Acanthamoeba
castellanii) 		5 / 12 PHE A  60
SER A  57
ASP A  51
ALA A  44
PHE A  49
 None
 1.17A 4u8vB-2acgA:
undetectable		 4u8vB-2acgA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2acg PROFILIN II
(Acanthamoeba
castellanii) 		5 / 12 PHE A  60
SER A  57
ASP A  51
ALA A  44
PHE A  49
 None
 1.17A 4u95B-2acgA:
undetectable		 4u95B-2acgA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2acg PROFILIN II
(Acanthamoeba
castellanii) 		3 / 3 VAL A  89
THR A  91
ARG A  75
 None
 0.79A 5b2tB-2acgA:
undetectable		 5b2tB-2acgA:
5.87