SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2acv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		4 / 8 GLY A 323
PHE A 324
LEU A 325
ARG A 296
 None
 0.72A 1d0vA-2acvA:
3.2		 1d0vA-2acvA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		5 / 12 ALA A 243
ILE A 238
LEU A 153
ILE A 215
THR A 219
 None
 1.06A 1d1gA-2acvA:
undetectable		 1d1gA-2acvA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		5 / 12 ALA A 243
ILE A 238
LEU A 153
ILE A 215
THR A 219
 None
 1.06A 1d1gB-2acvA:
undetectable		 1d1gB-2acvA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		5 / 11 ALA A 243
ILE A 238
LEU A 153
ILE A 215
THR A 219
 None
 1.08A 1dhiB-2acvA:
undetectable		 1dhiB-2acvA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		5 / 12 ALA A 243
ILE A 238
LEU A 153
ILE A 215
THR A 219
 None
 1.01A 1dhjB-2acvA:
undetectable		 1dhjB-2acvA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		3 / 3 ASP A 166
ASP A 168
ASP A 190
 None
 0.79A 1ej0A-2acvA:
3.8		 1ej0A-2acvA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		4 / 8 GLY A 323
PHE A 324
LEU A 325
ARG A 296
 None
 0.68A 1jhqA-2acvA:
1.3		 1jhqA-2acvA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		4 / 8 GLY A 323
PHE A 324
LEU A 325
ARG A 296
 None
 0.68A 1jhvA-2acvA:
3.0		 1jhvA-2acvA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		5 / 12 VAL A 217
LEU A 149
PHE A 148
LEU A 151
TYR A 202
 None
 1.36A 1kw0A-2acvA:
undetectable		 1kw0A-2acvA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		3 / 3 SER A 407
GLY A 406
ARG A 169
 None
 0.67A 1t9wA-2acvA:
undetectable		 1t9wA-2acvA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		4 / 5 PHE A  29
LEU A 457
PHE A  14
SER A  10
 None
 1.28A 1wrkB-2acvA:
undetectable		 1wrkB-2acvA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		5 / 12 THR A 375
LEU A 374
VAL A 371
PHE A 283
LEU A 419
 None
 1.29A 1wsvB-2acvA:
undetectable		 1wsvB-2acvA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		4 / 5 ALA A 201
TYR A 203
ALA A 191
TYR A 199
 None
 1.03A 1xl6A-2acvA:
undetectable
1xl6B-2acvA:
undetectable		 1xl6A-2acvA:
20.43
1xl6B-2acvA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		4 / 6 LEU A 310
LEU A 265
LEU A 267
LEU A 258
 None
 1.05A 2ab2A-2acvA:
undetectable		 2ab2A-2acvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		5 / 12 PHE A  45
ALA A  30
ILE A  13
ILE A 110
LEU A  40
 None
 1.33A 2bjfA-2acvA:
undetectable		 2bjfA-2acvA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		5 / 12 ALA A 243
ILE A 238
LEU A 153
ILE A 215
THR A 219
 None
 1.08A 2drcB-2acvA:
undetectable		 2drcB-2acvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		5 / 12 PHE A 209
LEU A 155
ILE A 241
LEU A 188
PRO A 189
 None
 1.18A 2hrcB-2acvA:
3.7		 2hrcB-2acvA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		4 / 6 SER A 185
LEU A 188
ASP A 165
ASP A 168
 None
 1.17A 2j2pE-2acvA:
undetectable
2j2pF-2acvA:
undetectable		 2j2pE-2acvA:
18.82
2j2pF-2acvA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		4 / 8 LEU A 223
ILE A 228
GLY A 178
ILE A 179
 None
 0.75A 2o4nB-2acvA:
undetectable		 2o4nB-2acvA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2REZ_A_ACTA155_0
(MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		4 / 5 TRP A 360
GLY A 245
PRO A 246
PHE A 220
 None
 1.42A 2rezA-2acvA:
0.0		 2rezA-2acvA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		4 / 4 ALA A 201
TYR A 203
ALA A 191
TYR A 199
 None
 0.99A 2wlkA-2acvA:
undetectable
2wlkB-2acvA:
undetectable		 2wlkA-2acvA:
20.43
2wlkB-2acvA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		5 / 12 ALA A 243
ILE A 238
LEU A 153
ILE A 215
THR A 219
 None
 1.07A 3drcB-2acvA:
undetectable		 3drcB-2acvA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		3 / 3 GLY A 398
ILE A 428
VAL A 429
 None
 0.52A 3nv6A-2acvA:
undetectable		 3nv6A-2acvA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		4 / 7 LEU A 188
LEU A 174
PRO A 177
ILE A 176
 None
 0.87A 3s56B-2acvA:
undetectable		 3s56B-2acvA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		4 / 8 ASN A 186
ASP A 170
VAL A 183
PHE A 193
 None
 1.04A 4f8hA-2acvA:
undetectable
4f8hB-2acvA:
undetectable		 4f8hA-2acvA:
23.80
4f8hB-2acvA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		4 / 8 ASN A 186
ASP A 170
VAL A 183
PHE A 193
 None
 1.05A 4f8hC-2acvA:
undetectable
4f8hD-2acvA:
undetectable		 4f8hC-2acvA:
23.80
4f8hD-2acvA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		4 / 8 ASN A 186
ASP A 170
VAL A 183
PHE A 193
 None
 1.04A 4f8hD-2acvA:
undetectable
4f8hE-2acvA:
undetectable		 4f8hD-2acvA:
23.80
4f8hE-2acvA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		4 / 8 VAL A 183
PHE A 193
ASN A 186
ASP A 170
 None
 1.05A 4f8hA-2acvA:
undetectable
4f8hE-2acvA:
undetectable		 4f8hA-2acvA:
23.80
4f8hE-2acvA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		5 / 11 GLY A 398
ALA A 386
LEU A 389
GLY A 396
ALA A  24
 None
 1.16A 4l6v1-2acvA:
undetectable
4l6v6-2acvA:
undetectable		 4l6v1-2acvA:
20.68
4l6v6-2acvA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		5 / 12 CYH A  46
ILE A  15
HIS A  22
LEU A  23
ALA A  26
 None
 1.00A 4p65F-2acvA:
undetectable
4p65H-2acvA:
undetectable
4p65K-2acvA:
undetectable
4p65L-2acvA:
undetectable		 4p65F-2acvA:
5.12
4p65H-2acvA:
5.12
4p65K-2acvA:
3.77
4p65L-2acvA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		5 / 12 GLY A 178
ASN A 181
PRO A 189
VAL A 217
THR A 219
 None
 1.03A 4q5mA-2acvA:
undetectable		 4q5mA-2acvA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		4 / 6 GLY A 245
PHE A 141
ILE A 216
PHE A  14
 None
 1.10A 4qogA-2acvA:
3.6
4qogB-2acvA:
3.9		 4qogA-2acvA:
19.91
4qogB-2acvA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		5 / 12 ILE A  15
GLY A 131
ILE A 136
ILE A 216
LEU A  33
 None
 0.96A 5e72A-2acvA:
3.7		 5e72A-2acvA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		5 / 9 ILE A 373
GLY A 353
LEU A 422
GLN A 382
LEU A 281
 None
None
None
UDP  A 900 ( 4.6A)
None
 1.35A 5fhzB-2acvA:
4.0		 5fhzB-2acvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		5 / 7 CYH A  46
ILE A  15
HIS A  22
LEU A  23
ALA A  26
 None
 1.00A 5hrqE-2acvA:
undetectable
5hrqF-2acvA:
undetectable
5hrqJ-2acvA:
undetectable		 5hrqE-2acvA:
3.77
5hrqF-2acvA:
5.35
5hrqJ-2acvA:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		5 / 7 ILE A  47
CYH A  46
HIS A  22
LEU A  23
ALA A  26
 None
 1.19A 5hrqE-2acvA:
undetectable
5hrqF-2acvA:
undetectable
5hrqJ-2acvA:
undetectable		 5hrqE-2acvA:
3.77
5hrqF-2acvA:
5.35
5hrqJ-2acvA:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1
(Medicago
truncatula) 		5 / 12 ILE A  15
ILE A  59
VAL A  62
LEU A  63
ILE A  69
 None
 0.84A 5mueA-2acvA:
undetectable		 5mueA-2acvA:
20.30