SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ad1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		3 / 3 THR A  25
THR A  23
PRO A  22
 None
 0.82A 1dscC-2ad1A:
undetectable		 1dscC-2ad1A:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		3 / 3 THR A  25
THR A  23
PRO A  22
 None
 0.88A 1fjaC-2ad1A:
undetectable		 1fjaC-2ad1A:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		3 / 3 THR A  25
THR A  23
PRO A  22
 None
 0.88A 1fjaD-2ad1A:
undetectable		 1fjaD-2ad1A:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		3 / 3 THR A  25
THR A  23
PRO A  22
 None
 0.85A 209dC-2ad1A:
undetectable		 209dC-2ad1A:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		4 / 5 LEU A 115
PRO A 116
LEU A 119
ILE A 126
 None
 0.83A 2qd4A-2ad1A:
undetectable		 2qd4A-2ad1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		3 / 3 ASN A 132
GLU A 195
ARG A 131
 None
 1.09A 3wxoA-2ad1A:
undetectable		 3wxoA-2ad1A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		4 / 4 LEU A 115
PRO A 116
LEU A 119
ILE A 126
 None
 0.89A 4f4dB-2ad1A:
undetectable		 4f4dB-2ad1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_A_SFYA807_0
(SEPIAPTERIN
REDUCTASE)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		5 / 11 LEU A 164
PHE A 160
TRP A 156
TYR A 159
PRO A 133
 None
 1.10A 4hwkA-2ad1A:
2.2		 4hwkA-2ad1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		5 / 11 LEU A 164
PHE A 160
TRP A 156
TYR A 159
PRO A 133
 None
 1.08A 4hwkB-2ad1A:
1.9		 4hwkB-2ad1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		5 / 12 LEU A 164
PHE A 160
TRP A 156
TYR A 159
PRO A 133
 None
 1.08A 4hwkC-2ad1A:
2.2		 4hwkC-2ad1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		5 / 11 LEU A 164
PHE A 160
TRP A 156
TYR A 159
PRO A 133
 None
 1.12A 4hwkD-2ad1A:
2.2		 4hwkD-2ad1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_A_YTZA802_1
(SEPIAPTERIN
REDUCTASE)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		5 / 10 LEU A 164
PHE A 160
TRP A 156
TYR A 159
PRO A 133
 None
 1.14A 4j7uA-2ad1A:
2.0		 4j7uA-2ad1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_B_YTZB802_1
(SEPIAPTERIN
REDUCTASE)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		5 / 10 LEU A 164
PHE A 160
TRP A 156
TYR A 159
PRO A 133
 None
 1.15A 4j7uB-2ad1A:
2.0		 4j7uB-2ad1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_C_YTZC802_1
(SEPIAPTERIN
REDUCTASE)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		5 / 10 LEU A 164
PHE A 160
TRP A 156
TYR A 159
PRO A 133
 None
 1.12A 4j7uC-2ad1A:
2.2		 4j7uC-2ad1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		5 / 8 LEU A 164
PHE A 160
TRP A 156
TYR A 159
PRO A 133
 None
 1.16A 4j7uD-2ad1A:
undetectable		 4j7uD-2ad1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		5 / 12 LEU A 164
PHE A 160
TRP A 156
TYR A 159
PRO A 133
 None
 1.08A 4j7xA-2ad1A:
undetectable		 4j7xA-2ad1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		5 / 12 LEU A 164
PHE A 160
TRP A 156
TYR A 159
PRO A 133
 None
 1.07A 4j7xB-2ad1A:
2.0		 4j7xB-2ad1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		5 / 12 LEU A 164
PHE A 160
TRP A 156
TYR A 159
PRO A 133
 None
 1.07A 4j7xF-2ad1A:
undetectable		 4j7xF-2ad1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		5 / 12 LEU A 164
PHE A 160
TRP A 156
TYR A 159
PRO A 133
 None
 1.08A 4j7xJ-2ad1A:
undetectable		 4j7xJ-2ad1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		4 / 5 LEU A 115
PRO A 116
LEU A 119
ILE A 126
 None
 0.75A 4klrA-2ad1A:
undetectable		 4klrA-2ad1A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		5 / 11 ALA A 183
GLY A 179
LEU A  83
LEU A  43
THR A 108
 None
 0.93A 4zmeA-2ad1A:
undetectable		 4zmeA-2ad1A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		3 / 3 LYS A 198
LEU A 192
ILE A 205
 None
 0.76A 5kc4A-2ad1A:
undetectable		 5kc4A-2ad1A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		4 / 6 LEU A 119
SER A 118
PHE A  35
HIS A  98
 None
 1.00A 5om3A-2ad1A:
undetectable
5om3B-2ad1A:
undetectable		 5om3A-2ad1A:
14.18
5om3B-2ad1A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_D_DZPD2001_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens) 		5 / 9 TYR A  47
ASN A 136
PHE A 277
TYR A 281
SER A 172
 None
 1.50A 6hupC-2ad1A:
0.0
6hupD-2ad1A:
0.0		 6hupC-2ad1A:
13.99
6hupD-2ad1A:
13.79