SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2adc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 2adc POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 361
PHE A 438
HIS A 512
LEU A 508
 None
None
U  B 535 ( 4.3A)
None
 1.16A 1x8vA-2adcA:
undetectable		 1x8vA-2adcA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2adc POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 394
GLN A 352
VAL A 379
VAL A 341
LEU A 344
 None
 0.88A 3gwxB-2adcA:
undetectable		 3gwxB-2adcA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 2adc POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 VAL A 349
LEU A 344
ILE A 404
VAL A 367
 None
 0.94A 4a9kA-2adcA:
0.0		 4a9kA-2adcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 2adc POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 9 ALA A 377
LEU A 339
LEU A 344
SER A 353
VAL A 349
 None
 1.15A 4or0B-2adcA:
undetectable		 4or0B-2adcA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2adc POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP A 383
ASN A 413
GLN A 412
 None
 0.77A 5k7uA-2adcA:
undetectable		 5k7uA-2adcA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2adc POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 VAL A 367
ILE A 369
VAL A 341
ALA A 377
 None
 0.52A 5ospA-2adcA:
undetectable		 5ospA-2adcA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2adc POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 VAL A 367
ILE A 369
VAL A 341
ALA A 377
 None
 0.50A 5osrA-2adcA:
undetectable		 5osrA-2adcA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 2adc POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 449
VAL A 360
LEU A 357
VAL A 501
LEU A 508
 None
 0.80A 6ajiA-2adcA:
3.4		 6ajiA-2adcA:
12.80