SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2adf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 2adf 82D6A3 IGG
(Mus
musculus) 		4 / 4 LEU L 124
ILE L 149
ARG L 154
TRP L 147
 None
 1.09A 1ie9A-2adfL:
undetectable		 1ie9A-2adfL:
20.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2adf 82D6A3 IGG
(Mus
musculus) 		4 / 7 TYR L  36
HIS L  38
PRO L  44
TYR L  87
 None
 0.54A 2oldA-2adfL:
15.8
2oldB-2adfL:
20.5		 2oldA-2adfL:
42.34
2oldB-2adfL:
42.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2adf 82D6A3 IGG
(Mus
musculus) 		4 / 7 TYR L  36
HIS L  38
PRO L  44
TYR L  87
 None
 0.59A 2ombC-2adfL:
18.5
2ombD-2adfL:
20.4		 2ombC-2adfL:
42.34
2ombD-2adfL:
42.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 2adf 82D6A3 IGG
(Mus
musculus) 		4 / 5 LEU L 124
ILE L 149
ARG L 154
TRP L 147
 None
 1.17A 2zlcA-2adfL:
undetectable		 2zlcA-2adfL:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 2adf 82D6A3 IGG
(Mus
musculus) 		5 / 12 PHE L  62
GLY L  16
LEU L  78
GLU L  79
SER L  76
 None
 1.26A 3tbgA-2adfL:
undetectable		 3tbgA-2adfL:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 2adf 82D6A3 IGG
(Mus
musculus) 		5 / 12 PHE L  62
GLY L  16
LEU L  78
GLU L  79
SER L  76
 None
 1.28A 3tbgC-2adfL:
undetectable		 3tbgC-2adfL:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 2adf 82D6A3 IGG
(Mus
musculus) 		4 / 4 LEU L  15
GLY L  16
LEU L  78
GLU L  79
 None
 1.02A 3tgvB-2adfL:
undetectable		 3tgvB-2adfL:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2adf 82D6A3 IGG
(Mus
musculus) 		5 / 8 LYS L 106
ALA L  13
GLY L  16
LEU L  78
LEU L 103
 None
 1.44A 4po0A-2adfL:
undetectable		 4po0A-2adfL:
18.13