SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ado'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1
(Homo
sapiens) 		5 / 12 SER A1924
ASP A1902
HIS A1954
VAL A1927
PHE A1897
 None
 1.28A 1uobA-2adoA:
undetectable		 1uobA-2adoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1
(Homo
sapiens) 		5 / 12 SER A1924
HIS A1954
ASP A1902
VAL A1927
PHE A1897
 None
 1.20A 1uobA-2adoA:
undetectable		 1uobA-2adoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1
(Homo
sapiens) 		5 / 12 TYR A2025
GLY A2023
ALA A2074
ILE A2017
PHE A2064
 None
 0.98A 1ve3A-2adoA:
undetectable		 1ve3A-2adoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1
(Homo
sapiens) 		5 / 12 TYR A2025
GLY A2023
ALA A2074
ILE A2017
PHE A2064
 None
 0.96A 1ve3B-2adoA:
undetectable		 1ve3B-2adoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A2065
ILE A2017
VAL A1935
CYH A2020
TYR A2025
 None
 1.35A 1wsvB-2adoA:
undetectable		 1wsvB-2adoA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A1981
ILE A1947
ALA A1940
ILE A2017
GLY A2068
 None
 1.04A 3nxuA-2adoA:
undetectable		 3nxuA-2adoA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1
(Homo
sapiens) 		3 / 3 THR A1971
VAL A1969
GLU A1976
 None
 0.69A 3v4tA-2adoA:
undetectable
3v4tD-2adoA:
undetectable		 3v4tA-2adoA:
18.42
3v4tD-2adoA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A1987
ILE A1947
ALA A1940
ILE A1931
PHE A1937
 None
 1.21A 4rp8C-2adoA:
undetectable		 4rp8C-2adoA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1
(Homo
sapiens) 		6 / 12 ILE A1945
ALA A1920
LEU A1938
THR A1928
LEU A1983
ILE A1947
 None
 1.37A 4x5iA-2adoA:
undetectable		 4x5iA-2adoA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1
(Homo
sapiens) 		5 / 12 THR A1928
LEU A1926
THR A1934
GLY A1918
ALA A1923
 None
 1.05A 4ypmA-2adoA:
undetectable		 4ypmA-2adoA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP A1902
VAL A1909
LEU A1916
 None
 0.64A 5e5jB-2adoA:
undetectable		 5e5jB-2adoA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1
(Homo
sapiens) 		4 / 8 VAL A1927
HIS A1954
PRO A1893
GLY A1914
 None
 0.84A 5w3jB-2adoA:
undetectable		 5w3jB-2adoA:
17.76