SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ae0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		4 / 6 TYR X  61
LEU X  53
VAL X 250
VAL X 258
 None
 1.16A 1dz4A-2ae0X:
undetectable		 1dz4A-2ae0X:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		5 / 12 ILE X  43
LEU X 296
GLY X 268
VAL X 250
ALA X 249
 None
 1.07A 1tlsA-2ae0X:
undetectable		 1tlsA-2ae0X:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		4 / 7 PRO X 104
GLY X 314
PRO X 315
GLY X 318
 None
 0.82A 1usqA-2ae0X:
undetectable		 1usqA-2ae0X:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		5 / 6 PRO X 104
GLY X 314
PRO X 315
GLY X 318
TYR X 102
 None
 1.04A 1usqB-2ae0X:
undetectable		 1usqB-2ae0X:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		5 / 6 PRO X 104
GLY X 314
PRO X 315
GLY X 318
TYR X 102
 None
 1.06A 1usqC-2ae0X:
undetectable		 1usqC-2ae0X:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		5 / 6 PRO X 104
GLY X 314
PRO X 315
GLY X 318
TYR X 102
 None
 1.05A 1usqD-2ae0X:
undetectable		 1usqD-2ae0X:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		5 / 6 PRO X 104
GLY X 314
PRO X 315
GLY X 318
TYR X 102
 None
 1.02A 1usqE-2ae0X:
undetectable		 1usqE-2ae0X:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		5 / 7 PRO X 104
GLY X 314
PRO X 315
GLY X 318
TYR X 102
 None
 1.06A 1usqF-2ae0X:
undetectable		 1usqF-2ae0X:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		5 / 6 PRO X 104
GLY X 314
PRO X 315
GLY X 318
TYR X 102
 None
 1.08A 2jkjA-2ae0X:
undetectable		 2jkjA-2ae0X:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		5 / 6 PRO X 104
GLY X 314
PRO X 315
GLY X 318
TYR X 102
 None
 1.08A 2jkjB-2ae0X:
undetectable		 2jkjB-2ae0X:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		5 / 6 PRO X 104
GLY X 314
PRO X 315
GLY X 318
TYR X 102
 None
 1.09A 2jkjC-2ae0X:
undetectable		 2jkjC-2ae0X:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		5 / 7 PRO X 104
GLY X 314
PRO X 315
GLY X 318
TYR X 102
 None
 1.07A 2jkjE-2ae0X:
undetectable		 2jkjE-2ae0X:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		4 / 7 PRO X 104
GLY X 314
PRO X 315
GLY X 318
 None
 0.80A 2jklA-2ae0X:
undetectable		 2jklA-2ae0X:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		5 / 6 PRO X 104
GLY X 314
PRO X 315
GLY X 318
TYR X 102
 None
 1.05A 2jklB-2ae0X:
undetectable		 2jklB-2ae0X:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		4 / 7 PRO X 104
GLY X 314
PRO X 315
GLY X 318
 None
 0.83A 2jklC-2ae0X:
undetectable		 2jklC-2ae0X:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		4 / 7 PRO X 104
GLY X 314
PRO X 315
GLY X 318
 None
 0.81A 2jklD-2ae0X:
undetectable		 2jklD-2ae0X:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		5 / 7 PRO X 104
GLY X 314
PRO X 315
GLY X 318
TYR X 102
 None
 1.04A 2jklE-2ae0X:
undetectable		 2jklE-2ae0X:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		4 / 7 PRO X 104
GLY X 314
PRO X 315
GLY X 318
 None
 0.81A 2jklF-2ae0X:
undetectable		 2jklF-2ae0X:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		4 / 5 TYR X  61
LEU X  53
VAL X 250
VAL X 258
 None
 1.14A 2m56A-2ae0X:
undetectable		 2m56A-2ae0X:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		3 / 3 ASN X 156
MET X 123
PHE X 233
 None
 1.05A 3g4lD-2ae0X:
undetectable		 3g4lD-2ae0X:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		4 / 6 MET X  87
VAL X 330
ILE X 265
LEU X 272
 None
 0.81A 3hegA-2ae0X:
undetectable		 3hegA-2ae0X:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		3 / 3 VAL X 332
VAL X 258
SER X 260
 EDO  X1439 ( 4.5A)
None
None
 0.74A 3n8xB-2ae0X:
undetectable		 3n8xB-2ae0X:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		4 / 8 LEU X 290
ARG X 291
ALA X 256
GLY X  72
 None
 0.77A 3ny4A-2ae0X:
undetectable		 3ny4A-2ae0X:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		4 / 6 ILE X 136
ASN X 184
PRO X 124
LEU X 141
 None
 1.12A 3oi8A-2ae0X:
undetectable		 3oi8A-2ae0X:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		5 / 12 GLY X  37
ILE X  43
ARG X 255
ALA X 256
LEU X 296
 None
 1.20A 3uj7B-2ae0X:
undetectable		 3uj7B-2ae0X:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		4 / 6 TYR X 121
ASP X 160
ASN X 156
TYR X 118
 None
 1.39A 3wfaA-2ae0X:
undetectable
3wfaB-2ae0X:
undetectable		 3wfaA-2ae0X:
19.53
3wfaB-2ae0X:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		3 / 3 GLN X  57
THR X 269
THR X 270
 None
 0.82A 4fufA-2ae0X:
undetectable		 4fufA-2ae0X:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		5 / 12 GLY X 165
GLY X 163
ILE X 158
ASP X 155
ILE X 106
 None
 1.11A 4iv0B-2ae0X:
undetectable		 4iv0B-2ae0X:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		4 / 8 PRO X  27
LEU X 272
VAL X  64
LEU X 290
 None
 0.80A 4pwdA-2ae0X:
undetectable		 4pwdA-2ae0X:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		4 / 6 ASP X 297
ASP X  38
ARG X 255
GLN X 311
 None
 0.95A 5l6eA-2ae0X:
undetectable		 5l6eA-2ae0X:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_1
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A
(Escherichia
coli) 		4 / 5 GLN X  42
GLU X  41
ASN X  35
TYR X 310
 None
 1.30A 6iftA-2ae0X:
undetectable		 6iftA-2ae0X:
21.30