SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ae6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 2ae6 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 5 PHE A 129
TYR A 130
LEU A  82
VAL A  86
 None
 1.34A 1dz6A-2ae6A:
undetectable		 1dz6A-2ae6A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 2ae6 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 10 SER A 110
ILE A 112
ILE A 161
LEU A 115
ILE A  65
 None
 1.24A 2nnhB-2ae6A:
undetectable		 2nnhB-2ae6A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 2ae6 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 11 ARG A   8
ILE A  52
ALA A  55
LEU A  18
ASP A  14
 None
 1.06A 2q72A-2ae6A:
undetectable		 2q72A-2ae6A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 2ae6 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 11 LEU A   9
ARG A   8
ALA A  55
LEU A  18
ASP A  14
 None
 1.09A 2q72A-2ae6A:
undetectable		 2q72A-2ae6A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 2ae6 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 12 LEU A   9
ARG A   8
ALA A  55
LEU A  18
ASP A  14
 None
 1.09A 2qb4A-2ae6A:
undetectable		 2qb4A-2ae6A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 2ae6 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 11 LEU A   9
ARG A   8
ALA A  55
LEU A  18
ASP A  14
 None
 1.15A 2qjuA-2ae6A:
undetectable		 2qjuA-2ae6A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 2ae6 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 5 PHE A 129
ILE A  84
GLY A  94
HIS A 133
 None
 1.19A 3r0lD-2ae6A:
undetectable		 3r0lD-2ae6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2ae6 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 4 GLY A  94
VAL A  86
PHE A  53
ILE A  65
 None
 1.17A 4xv2B-2ae6A:
undetectable		 4xv2B-2ae6A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 2ae6 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 10 TYR A  43
ASP A  22
VAL A  10
TRP A  15
ILE A  84
 None
 1.35A 5hw8C-2ae6A:
undetectable
5hw8H-2ae6A:
undetectable		 5hw8C-2ae6A:
20.86
5hw8H-2ae6A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 2ae6 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 5 SER A  87
VAL A  86
GLY A  63
ALA A  62
 None
 1.00A 5k50A-2ae6A:
0.0		 5k50A-2ae6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2ae6 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 9 ASP A 105
ILE A  65
SER A 101
SER A  98
GLY A  97
 MG  A 302 ( 4.4A)
None
MG  A 302 (-2.4A)
None
None
 1.43A 6awpA-2ae6A:
undetectable		 6awpA-2ae6A:
15.08