SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aee'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 2aee OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 129
THR A 153
VAL A 148
ALA A 159
SER A 160
 SO4  A 501 (-3.8A)
None
None
None
None
 1.05A 3d91B-2aeeA:
undetectable		 3d91B-2aeeA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 2aee OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Streptococcus
pyogenes) 		5 / 12 THR A 172
LEU A 173
LEU A 197
ILE A   7
ILE A 189
 None
 1.04A 3frqB-2aeeA:
undetectable		 3frqB-2aeeA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 2aee OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Streptococcus
pyogenes) 		4 / 6 LEU A 124
ALA A 150
SER A 174
THR A 172
 None
 1.24A 4d7bB-2aeeA:
undetectable		 4d7bB-2aeeA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2aee OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Streptococcus
pyogenes) 		5 / 8 LEU A 132
GLY A 128
VAL A 131
ALA A 135
GLY A 167
 None
SO4  A 501 (-3.3A)
None
None
None
 1.21A 4zauA-2aeeA:
undetectable		 4zauA-2aeeA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 2aee OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Streptococcus
pyogenes) 		4 / 6 LEU A 124
ALA A 150
SER A 174
THR A 172
 None
 1.21A 5l4iB-2aeeA:
undetectable		 5l4iB-2aeeA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 2aee OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Streptococcus
pyogenes) 		5 / 12 ALA A  74
ARG A  40
GLY A  77
GLY A  81
ILE A  83
 None
GOL  A2431 (-3.6A)
None
None
None
 1.20A 5ul4A-2aeeA:
3.7		 5ul4A-2aeeA:
15.97