SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aeh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 2aeh FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		4 / 8 GLY A 275
GLY A 279
TYR A 347
VAL A 329
 None
 0.91A 1dbbH-2aehA:
undetectable
1dbbL-2aehA:
undetectable		 1dbbH-2aehA:
20.55
1dbbL-2aehA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 2aeh FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 TYR A 128
ALA A 294
ILE A 320
ASP A 101
ILE A 359
 None
 1.11A 1x1aA-2aehA:
undetectable		 1x1aA-2aehA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2aeh FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		3 / 3 GLY A 132
GLU A 277
ASN A 135
 None
 0.72A 1zq9A-2aehA:
undetectable		 1zq9A-2aehA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 2aeh FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 11 LEU A 223
ILE A 224
GLY A 172
CYH A 173
LEU A 211
 None
 1.34A 2bxeA-2aehA:
undetectable		 2bxeA-2aehA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2aeh FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 LEU A 174
PHE A 231
LEU A 171
PRO A 249
VAL A 250
 None
 1.30A 2pnjB-2aehA:
undetectable		 2pnjB-2aehA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2aeh FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		3 / 3 LEU A 316
TYR A 304
GLN A 303
 None
 0.72A 2wekA-2aehA:
undetectable		 2wekA-2aehA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 2aeh FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 LEU A 174
PHE A 231
LEU A 171
PRO A 249
VAL A 250
 None
 1.29A 3aqiB-2aehA:
undetectable		 3aqiB-2aehA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2aeh FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 ILE A  56
ILE A  67
VAL A  64
GLY A 103
ARG A  35
 None
 1.17A 3em0B-2aehA:
1.5		 3em0B-2aehA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2aeh FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 LEU A 220
LEU A 203
ARG A 221
LEU A 188
ILE A 224
 None
 1.07A 4x1fA-2aehA:
undetectable		 4x1fA-2aehA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2aeh FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 LEU A 220
LEU A 203
ARG A 221
LEU A 188
ILE A 224
 None
 1.04A 4x1gA-2aehA:
undetectable		 4x1gA-2aehA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 2aeh FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		4 / 5 PHE A 147
PHE A 243
PHE A 244
VAL A 151
 None
 1.20A 5a1rA-2aehA:
undetectable		 5a1rA-2aehA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2aeh FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 8 LEU A 272
VAL A 329
ILE A 280
GLY A 279
ILE A 359
 None
 1.09A 5vkqB-2aehA:
undetectable
5vkqC-2aehA:
undetectable		 5vkqB-2aehA:
11.25
5vkqC-2aehA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2aeh FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		3 / 3 LEU A 129
ASP A 295
ILE A 280
 None
 0.60A 6dh0B-2aehA:
undetectable		 6dh0B-2aehA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 2aeh FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 LEU A 343
GLY A 279
ASP A 295
ILE A 320
ILE A 344
 None
 0.94A 6dh6A-2aehA:
undetectable		 6dh6A-2aehA:
14.11