SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aeq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 2aeq FAB HEAVY CHAIN
(Mus
musculus) 		4 / 8 ALA H  90
GLY H  42
SER H  93
ALA H  94
 None
 0.90A 2vh3B-2aeqH:
undetectable		 2vh3B-2aeqH:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 2aeq FAB HEAVY CHAIN
(Mus
musculus) 		5 / 11 VAL H   2
MET H  34
ARG H  74
ASN H  76
VAL H  81
 None
 0.82A 3qxvC-2aeqH:
18.2		 3qxvC-2aeqH:
33.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 2aeq FAB HEAVY CHAIN
(Mus
musculus) 		4 / 6 LEU H  48
SER H  63
TYR H  62
ALA H  64
 None
 0.99A 3ravA-2aeqH:
undetectable		 3ravA-2aeqH:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2aeq FAB HEAVY CHAIN
(Mus
musculus) 		5 / 12 LEU H  18
SER H  93
THR H  89
LEU H  88
VAL H  12
 None
 0.94A 5twjA-2aeqH:
undetectable		 5twjA-2aeqH:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2aeq FAB HEAVY CHAIN
(Mus
musculus) 		5 / 10 LEU H  18
LEU H 116
SER H  93
LEU H  88
VAL H  12
 None
 1.12A 5twjB-2aeqH:
undetectable		 5twjB-2aeqH:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2aeq FAB HEAVY CHAIN
(Mus
musculus) 		5 / 12 LEU H  18
LEU H 116
SER H  93
LEU H  88
VAL H  12
 None
 1.12A 5twjC-2aeqH:
undetectable		 5twjC-2aeqH:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2aeq FAB HEAVY CHAIN
(Mus
musculus) 		5 / 11 LEU H  18
SER H  93
THR H  89
LEU H  88
VAL H  12
 None
 0.95A 5twjD-2aeqH:
undetectable		 5twjD-2aeqH:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 2aeq FAB HEAVY CHAIN
(Mus
musculus) 		5 / 12 ALA H  99
TYR H  62
VAL H  81
ASP H  31
PHE H  29
 None
 1.45A 5vlmC-2aeqH:
undetectable		 5vlmC-2aeqH:
20.91