SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aeu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		4 / 6 SER A  86
THR A  85
ASN A  83
LEU A 243
 SO4  A1002 ( 4.6A)
SO4  A1001 (-2.7A)
None
None
 1.38A 1mxdA-2aeuA:
undetectable		 1mxdA-2aeuA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		4 / 8 ALA A 168
ASP A 178
ILE A 146
ILE A 156
 None
 0.92A 1rg9B-2aeuA:
undetectable		 1rg9B-2aeuA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		5 / 11 ARG A 265
GLU A 353
LEU A  33
ILE A 360
ASP A 357
 None
 1.15A 1t6zA-2aeuA:
undetectable		 1t6zA-2aeuA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A 351
ARG A 350
ASP A  28
 None
SO4  A1010 (-2.6A)
None
 0.82A 1vptA-2aeuA:
2.5		 1vptA-2aeuA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A 179
GLY A 182
ALA A 183
ALA A 199
VAL A 202
 None
 0.91A 2b7zB-2aeuA:
undetectable		 2b7zB-2aeuA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		5 / 11 THR A  52
ILE A  54
GLY A  55
TYR A  58
PHE A  59
 None
 1.00A 2y7kA-2aeuA:
undetectable		 2y7kA-2aeuA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		5 / 10 THR A  52
ILE A  54
GLY A  55
TYR A  58
PHE A  59
 None
 1.00A 2y7kB-2aeuA:
0.1		 2y7kB-2aeuA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A  52
ILE A  54
GLY A  55
TYR A  58
PHE A  59
 None
 1.06A 2y7kC-2aeuA:
undetectable		 2y7kC-2aeuA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A  52
ILE A  54
GLY A  55
TYR A  58
PHE A  59
 None
 1.10A 2y7kD-2aeuA:
undetectable		 2y7kD-2aeuA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		4 / 7 THR A  52
ILE A  54
GLY A  55
PHE A  59
 None
 0.79A 2y7wC-2aeuA:
undetectable		 2y7wC-2aeuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 244
ASP A 207
LEU A 218
VAL A  63
ILE A 247
 None
SO4  A1001 (-4.0A)
None
None
None
 0.94A 3em3A-2aeuA:
undetectable		 3em3A-2aeuA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A 182
ALA A 180
THR A  85
ILE A  89
 None
SO4  A1001 ( 4.6A)
SO4  A1001 (-2.7A)
None
 0.81A 3jusB-2aeuA:
undetectable		 3jusB-2aeuA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		4 / 6 ILE A 312
ILE A 328
GLY A 319
VAL A 300
 None
 0.84A 3n3iA-2aeuA:
undetectable		 3n3iA-2aeuA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A 244
ASP A 207
VAL A 203
VAL A  63
ILE A 247
 None
SO4  A1001 (-4.0A)
None
None
None
 0.81A 3oxxB-2aeuA:
undetectable		 3oxxB-2aeuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		4 / 8 ASP A  74
ASP A  77
GLY A 220
GLU A  75
 None
 0.99A 3s3mA-2aeuA:
undetectable		 3s3mA-2aeuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		4 / 8 ASP A  74
ASP A  77
GLY A 220
GLU A  75
 None
 0.93A 3s3nA-2aeuA:
undetectable		 3s3nA-2aeuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		3 / 3 SER A  57
PHE A  59
LYS A  62
 None
 0.97A 3u88A-2aeuA:
undetectable		 3u88A-2aeuA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ACTA908_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		4 / 4 MET A 151
SER A 181
LEU A 209
VAL A 185
 None
SO4  A1003 ( 4.7A)
None
None
 1.40A 3vlnA-2aeuA:
0.0		 3vlnA-2aeuA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 180
SER A 205
VAL A 203
SER A 117
PHE A 176
 SO4  A1001 ( 4.6A)
SO4  A1001 (-2.6A)
None
None
None
 1.26A 4c49A-2aeuA:
undetectable		 4c49A-2aeuA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A 351
ARG A 350
ASP A  28
 None
SO4  A1010 (-2.6A)
None
 0.63A 4fp9D-2aeuA:
undetectable		 4fp9D-2aeuA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A 351
ARG A 350
ASP A  28
 None
SO4  A1010 (-2.6A)
None
 0.73A 4fzvA-2aeuA:
undetectable		 4fzvA-2aeuA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A  92
LEU A  94
ALA A  91
GLY A 216
LEU A 218
 None
 1.14A 5gs4A-2aeuA:
undetectable		 5gs4A-2aeuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		5 / 11 ASP A 356
VAL A 365
ILE A 364
ILE A 355
PHE A 269
 None
 1.12A 5hw8D-2aeuA:
undetectable		 5hw8D-2aeuA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		5 / 11 ASP A 356
VAL A 365
ILE A 364
ILE A 355
PHE A 269
 None
 1.10A 5hw8E-2aeuA:
undetectable		 5hw8E-2aeuA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  94
ALA A  95
GLU A 231
LEU A 237
LEU A 201
 None
 1.38A 5hyrB-2aeuA:
undetectable		 5hyrB-2aeuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 228
ALA A  95
GLY A  81
GLY A 232
GLY A 220
 None
 0.95A 5i73A-2aeuA:
undetectable		 5i73A-2aeuA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		3 / 3 LYS A 314
LEU A 322
ILE A 301
 None
 0.33A 5kc0A-2aeuA:
undetectable		 5kc0A-2aeuA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		3 / 3 LYS A 314
LEU A 322
ILE A 301
 None
 0.63A 5kc4A-2aeuA:
undetectable		 5kc4A-2aeuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		4 / 7 TYR A  31
ILE A 328
ILE A 329
ILE A  17
 None
 0.94A 5murB-2aeuA:
undetectable		 5murB-2aeuA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		4 / 6 GLN A 191
PHE A 189
LEU A 256
PHE A 254
 None
 1.11A 5zcpC-2aeuA:
undetectable
5zcpJ-2aeuA:
undetectable		 5zcpC-2aeuA:
20.26
5zcpJ-2aeuA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A 322
ILE A 329
THR A 330
TYR A 359
 None
 0.85A 5zsfA-2aeuA:
0.0
5zsfB-2aeuA:
0.0		 5zsfA-2aeuA:
13.94
5zsfB-2aeuA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A 351
ARG A 350
ASP A  28
 None
SO4  A1010 (-2.6A)
None
 0.89A 5zvgB-2aeuA:
3.1		 5zvgB-2aeuA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		4 / 4 HIS A  70
VAL A 202
LEU A  71
ALA A 183
 None
 1.19A 6d8pB-2aeuA:
2.8		 6d8pB-2aeuA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 2aeu HYPOTHETICAL PROTEIN
MJ0158
(Methanocaldococc
us
jannaschii) 		4 / 7 PHE A 176
GLY A 216
LEU A 237
GLY A 232
 None
 0.74A 6eu9D-2aeuA:
undetectable		 6eu9D-2aeuA:
14.98