SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aex'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2aex COPROPORPHYRINOGEN
III OXIDASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A 339
PHE A 353
HIS A 297
SER A 364
TYR A 261
 None
 0.94A 3apvA-2aexA:
undetectable		 3apvA-2aexA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2aex COPROPORPHYRINOGEN
III OXIDASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A 259
GLY A 204
SER A 245
PHE A 200
ASP A 171
 None
 1.33A 3iv6B-2aexA:
undetectable		 3iv6B-2aexA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 2aex COPROPORPHYRINOGEN
III OXIDASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLY A 212
PHE A 238
PHE A 405
PHE A 408
 None
 1.03A 3ko0D-2aexA:
undetectable
3ko0E-2aexA:
undetectable		 3ko0D-2aexA:
15.53
3ko0E-2aexA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 2aex COPROPORPHYRINOGEN
III OXIDASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 288
GLY A 333
PHE A 296
TRP A 452
PRO A 255
 None
 1.19A 3mecA-2aexA:
undetectable		 3mecA-2aexA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2aex COPROPORPHYRINOGEN
III OXIDASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 391
THR A 286
TRP A 384
 None
 0.88A 4d7hA-2aexA:
undetectable		 4d7hA-2aexA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2aex COPROPORPHYRINOGEN
III OXIDASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 336
GLY A 333
LEU A 446
VAL A 445
 None
 0.91A 4fgzA-2aexA:
undetectable		 4fgzA-2aexA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2aex COPROPORPHYRINOGEN
III OXIDASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 391
THR A 286
TRP A 384
 None
 0.99A 4ug5A-2aexA:
undetectable		 4ug5A-2aexA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 2aex COPROPORPHYRINOGEN
III OXIDASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 391
THR A 286
TRP A 384
 None
 0.91A 4uglA-2aexA:
undetectable		 4uglA-2aexA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2aex COPROPORPHYRINOGEN
III OXIDASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 391
THR A 286
TRP A 384
 None
 0.92A 5g6cA-2aexA:
undetectable		 5g6cA-2aexA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2aex COPROPORPHYRINOGEN
III OXIDASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 VAL A 205
GLN A 162
CYH A 164
 None
 0.71A 5icxA-2aexA:
undetectable
5icxE-2aexA:
undetectable		 5icxA-2aexA:
20.29
5icxE-2aexA:
3.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 2aex COPROPORPHYRINOGEN
III OXIDASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 PRO A 134
ARG A 180
GLU A 153
 None
 1.00A 5j6hA-2aexA:
undetectable		 5j6hA-2aexA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2aex COPROPORPHYRINOGEN
III OXIDASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 THR A 409
MET A 222
ALA A 218
SER A 215
 None
 1.11A 5l5fY-2aexA:
undetectable
5l5fZ-2aexA:
0.0		 5l5fY-2aexA:
19.88
5l5fZ-2aexA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2aex COPROPORPHYRINOGEN
III OXIDASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 SER A 420
TYR A 392
ASP A 400
THR A 284
 None
 1.23A 6djzA-2aexA:
undetectable		 6djzA-2aexA:
21.13