SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aey'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		5 / 10 GLY A 405
ARG A 426
PHE A 424
GLY A 514
PHE A 511
 None
 1.32A 1ho5B-2aeyA:
undetectable		 1ho5B-2aeyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 6 LEU A 175
TRP A 159
THR A  87
TYR A 244
 None
 1.37A 1qvuA-2aeyA:
undetectable		 1qvuA-2aeyA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		3 / 3 TRP A 184
PHE A 181
TRP A 159
 None
 0.79A 1r15C-2aeyA:
undetectable		 1r15C-2aeyA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		3 / 3 TRP A 184
PHE A 181
TRP A 159
 None
 0.80A 1r15F-2aeyA:
undetectable		 1r15F-2aeyA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		3 / 3 TRP A 184
PHE A 181
TRP A 159
 None
 0.80A 1r15G-2aeyA:
undetectable		 1r15G-2aeyA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		3 / 3 TRP A 184
PHE A 181
TRP A 159
 None
 0.79A 1r15H-2aeyA:
undetectable		 1r15H-2aeyA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		3 / 3 ASN A  21
TRP A  19
GLN A 311
 DQQ  A 801 (-3.5A)
None
None
 1.15A 1xoqA-2aeyA:
undetectable		 1xoqA-2aeyA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 4 PRO A 203
ASP A 237
ASP A 269
ASP A  22
 None
None
None
DQQ  A 801 (-2.8A)
 1.45A 2nyuA-2aeyA:
undetectable		 2nyuA-2aeyA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OWC_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		5 / 11 TYR A 274
GLN A 272
GLN A 311
ASP A 237
ASP A  22
 DQQ  A 801 ( 4.9A)
None
None
None
DQQ  A 801 (-2.8A)
 1.36A 2owcA-2aeyA:
undetectable		 2owcA-2aeyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		5 / 12 LEU A 475
LEU A 310
GLN A  14
ARG A   8
LEU A 337
 None
 1.50A 2w8yB-2aeyA:
undetectable		 2w8yB-2aeyA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		5 / 11 MET A 523
ILE A 520
LEU A 508
LEU A 344
ILE A 357
 None
 1.39A 3a50B-2aeyA:
undetectable		 3a50B-2aeyA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 5 THR A 240
PHE A 251
PHE A 205
TYR A 206
 None
 1.33A 3em0A-2aeyA:
undetectable		 3em0A-2aeyA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 7 PRO A 203
GLY A 232
ALA A 231
ALA A 194
 None
 0.73A 3ur0B-2aeyA:
undetectable		 3ur0B-2aeyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 6 ILE A 452
TRP A  19
TRP A 292
TRP A 307
 None
 1.28A 3welA-2aeyA:
undetectable		 3welA-2aeyA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 6 ILE A 452
TRP A  19
TRP A 292
TRP A 307
 None
 1.27A 3weoA-2aeyA:
undetectable		 3weoA-2aeyA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_A_ACHA301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 7 TYR A 206
THR A 240
TYR A 268
TYR A 239
 None
 1.44A 3wipA-2aeyA:
0.0
3wipB-2aeyA:
0.0		 3wipA-2aeyA:
17.21
3wipB-2aeyA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 8 TYR A 206
THR A 240
TYR A 268
TYR A 239
 None
 1.49A 3wipB-2aeyA:
undetectable
3wipC-2aeyA:
undetectable		 3wipB-2aeyA:
17.21
3wipC-2aeyA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_F_ACHF301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 7 TYR A 206
THR A 240
TYR A 268
TYR A 239
 None
 1.44A 3wipF-2aeyA:
0.0
3wipG-2aeyA:
0.0		 3wipF-2aeyA:
17.21
3wipG-2aeyA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		3 / 3 GLN A  14
ASP A 477
GLN A 364
 None
 0.77A 4aztA-2aeyA:
undetectable		 4aztA-2aeyA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 6 SER A  57
ASP A 281
ARG A 286
GLU A 333
 None
 0.98A 4eysA-2aeyA:
undetectable		 4eysA-2aeyA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		5 / 9 GLY A 405
ARG A 426
PHE A 424
GLY A 514
PHE A 511
 None
 1.34A 4h2fA-2aeyA:
undetectable		 4h2fA-2aeyA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		3 / 3 SER A 276
TYR A 268
PRO A  26
 None
 0.87A 4k8cA-2aeyA:
undetectable		 4k8cA-2aeyA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		3 / 3 SER A 276
TYR A 268
PRO A  26
 None
 0.88A 4kahA-2aeyA:
undetectable		 4kahA-2aeyA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		3 / 3 SER A 276
TYR A 268
PRO A  26
 None
 0.88A 4kahB-2aeyA:
undetectable		 4kahB-2aeyA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		3 / 3 SER A 276
TYR A 268
PRO A  26
 None
 0.88A 4kanA-2aeyA:
undetectable		 4kanA-2aeyA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		3 / 3 SER A 276
TYR A 268
PRO A  26
 None
 0.86A 4kanB-2aeyA:
undetectable		 4kanB-2aeyA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		3 / 3 SER A 276
TYR A 268
PRO A  26
 None
 0.88A 4kbeA-2aeyA:
undetectable		 4kbeA-2aeyA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		3 / 3 SER A 276
TYR A 268
PRO A  26
 None
 0.88A 4kbeB-2aeyA:
undetectable		 4kbeB-2aeyA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 6 GLU A 124
ARG A 123
ASP A  67
ASP A 536
 None
 1.40A 4kcnA-2aeyA:
undetectable		 4kcnA-2aeyA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		3 / 3 SER A 276
TYR A 268
PRO A  26
 None
 0.85A 4lbgA-2aeyA:
undetectable		 4lbgA-2aeyA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		3 / 3 SER A 276
TYR A 268
PRO A  26
 None
 0.86A 4lbgB-2aeyA:
undetectable		 4lbgB-2aeyA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 6 PHE A 313
ASP A 366
TYR A  11
LEU A 337
 None
 1.37A 4paeA-2aeyA:
undetectable		 4paeA-2aeyA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 5 TYR A  11
GLN A 364
SER A 363
ASP A 297
 None
 1.49A 4qtuB-2aeyA:
undetectable		 4qtuB-2aeyA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		3 / 3 ALA A 112
TRP A 125
VAL A 126
 None
 0.44A 4w9nC-2aeyA:
undetectable		 4w9nC-2aeyA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 8 GLY A  10
SER A 363
ASN A 530
HIS A 478
 None
 1.01A 4wryA-2aeyA:
undetectable		 4wryA-2aeyA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 8 GLY A  10
SER A 363
ASN A 530
HIS A 478
 None
 1.02A 4wrzA-2aeyA:
undetectable		 4wrzA-2aeyA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 8 GLY A  10
SER A 363
ASN A 530
HIS A 478
 None
 0.98A 4ws1A-2aeyA:
undetectable		 4ws1A-2aeyA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA302_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 5 PRO A  94
MET A  27
HIS A  34
TRP A 125
 None
 1.18A 4ww7A-2aeyA:
0.0		 4ww7A-2aeyA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		3 / 3 GLU A 304
TRP A 307
ASN A 502
 None
 1.13A 5dv4A-2aeyA:
undetectable		 5dv4A-2aeyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		3 / 3 PRO A 406
ILE A 476
SER A 400
 None
 0.78A 5fsaA-2aeyA:
undetectable		 5fsaA-2aeyA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		3 / 3 PRO A 253
LEU A 266
SER A 258
 None
 0.57A 5fsaB-2aeyA:
undetectable		 5fsaB-2aeyA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 6 GLU A 295
GLY A 309
ARG A 495
ARG A   8
 None
 1.45A 5jcnB-2aeyA:
undetectable		 5jcnB-2aeyA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		5 / 12 GLY A 485
ASP A 269
LEU A 443
GLY A 458
PHE A 425
 None
 1.04A 5vooA-2aeyA:
undetectable		 5vooA-2aeyA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		5 / 12 GLY A 485
ASP A 269
LEU A 443
GLY A 458
PHE A 425
 None
 1.09A 5vooC-2aeyA:
undetectable		 5vooC-2aeyA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 5 VAL A 461
PRO A 389
GLY A 458
TYR A 270
 None
 1.35A 5x80A-2aeyA:
undetectable
5x80B-2aeyA:
undetectable		 5x80A-2aeyA:
15.64
5x80B-2aeyA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 5 PRO A 389
GLY A 458
TYR A 270
VAL A 461
 None
 1.25A 5x80C-2aeyA:
undetectable
5x80D-2aeyA:
undetectable		 5x80C-2aeyA:
15.64
5x80D-2aeyA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 5 PRO A 314
VAL A 288
GLY A  84
TRP A  52
 None
 1.02A 6ak3B-2aeyA:
undetectable		 6ak3B-2aeyA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 5 GLN A 311
VAL A 293
TRP A 292
PRO A  23
 None
 1.39A 6cduA-2aeyA:
0.0
6cduB-2aeyA:
0.0		 6cduA-2aeyA:
21.88
6cduB-2aeyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 7 ILE A 134
VAL A 108
PRO A 148
ALA A  76
 None
 0.93A 6cduC-2aeyA:
undetectable
6cduD-2aeyA:
undetectable		 6cduC-2aeyA:
21.88
6cduD-2aeyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		5 / 12 LEU A  60
LEU A  28
GLY A  31
VAL A  56
ILE A  64
 None
 0.98A 6ecxA-2aeyA:
undetectable		 6ecxA-2aeyA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 2aey FRUCTAN
1-EXOHYDROLASE IIA
(Cichorium
intybus) 		4 / 4 LEU A 376
ASP A 464
PRO A 465
ARG A 466
 None
 1.10A 6fgdA-2aeyA:
undetectable		 6fgdA-2aeyA:
21.59