SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2af4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2af4 PHOSPHATE
ACETYLTRANSFERASE
(Methanosarcina
thermophila) 		5 / 12 ILE C 249
VAL C 156
ALA C 285
ILE C 154
ILE C 153
 None
CSO  C 159 ( 4.2A)
None
None
None
 1.03A 1epbB-2af4C:
undetectable		 1epbB-2af4C:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2af4 PHOSPHATE
ACETYLTRANSFERASE
(Methanosarcina
thermophila) 		4 / 5 LEU C 197
VAL C 326
CYH C 325
ALA C  42
 None
 0.95A 1mz9D-2af4C:
undetectable		 1mz9D-2af4C:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2af4 PHOSPHATE
ACETYLTRANSFERASE
(Methanosarcina
thermophila) 		4 / 4 LEU C  21
VAL C 321
CYH C 325
ALA C  12
 None
 1.29A 1mz9E-2af4C:
undetectable		 1mz9E-2af4C:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2af4 PHOSPHATE
ACETYLTRANSFERASE
(Methanosarcina
thermophila) 		4 / 4 LEU C 197
VAL C 326
CYH C 325
ALA C  42
 None
 1.13A 1mz9E-2af4C:
undetectable		 1mz9E-2af4C:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2af4 PHOSPHATE
ACETYLTRANSFERASE
(Methanosarcina
thermophila) 		4 / 7 VAL C 120
GLY C 119
ILE C 138
VAL C 139
 None
 0.56A 1p2yA-2af4C:
undetectable		 1p2yA-2af4C:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2af4 PHOSPHATE
ACETYLTRANSFERASE
(Methanosarcina
thermophila) 		5 / 12 GLY C 241
GLY C 213
VAL C 263
ILE C 239
MET C 206
 None
 0.95A 2b25A-2af4C:
undetectable		 2b25A-2af4C:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2af4 PHOSPHATE
ACETYLTRANSFERASE
(Methanosarcina
thermophila) 		5 / 12 LEU C  30
LEU C  62
GLY C  48
ASP C 103
ALA C 108
 None
 1.17A 2bm9A-2af4C:
3.4		 2bm9A-2af4C:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2af4 PHOSPHATE
ACETYLTRANSFERASE
(Methanosarcina
thermophila) 		5 / 12 LEU C  30
LEU C  62
GLY C  48
ASP C 103
ALA C 108
 None
 1.24A 2bm9B-2af4C:
2.9		 2bm9B-2af4C:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 2af4 PHOSPHATE
ACETYLTRANSFERASE
(Methanosarcina
thermophila) 		4 / 8 ALA C 170
GLN C 299
THR C 193
ILE C 186
 None
 0.77A 2dtjA-2af4C:
undetectable
2dtjB-2af4C:
undetectable		 2dtjA-2af4C:
20.42
2dtjB-2af4C:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 2af4 PHOSPHATE
ACETYLTRANSFERASE
(Methanosarcina
thermophila) 		4 / 7 SER C 190
VAL C 175
ILE C 186
THR C 141
 None
 0.99A 3tneB-2af4C:
undetectable		 3tneB-2af4C:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2af4 PHOSPHATE
ACETYLTRANSFERASE
(Methanosarcina
thermophila) 		4 / 8 ILE C 317
LEU C  21
ILE C  41
GLY C 119
 None
 0.85A 4hb8A-2af4C:
undetectable		 4hb8A-2af4C:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2af4 PHOSPHATE
ACETYLTRANSFERASE
(Methanosarcina
thermophila) 		5 / 12 GLY C 241
ALA C 230
ALA C 225
ILE C 224
ALA C 267
 None
 0.93A 5bw4B-2af4C:
3.0		 5bw4B-2af4C:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2af4 PHOSPHATE
ACETYLTRANSFERASE
(Methanosarcina
thermophila) 		3 / 3 TYR C 106
ALA C  82
LEU C  86
 None
 0.62A 6ag0C-2af4C:
undetectable		 6ag0C-2af4C:
16.29