SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2af5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS
(Borreliella
burgdorferi) 		4 / 7 SER A 121
LEU A  88
LEU A  99
THR A 115
 None
 0.87A 3cfqA-2af5A:
undetectable
3cfqB-2af5A:
undetectable		 3cfqA-2af5A:
18.73
3cfqB-2af5A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS
(Borreliella
burgdorferi) 		4 / 7 LYS A 279
LEU A 281
LEU A 269
VAL A 273
 None
 0.92A 3d2tA-2af5A:
undetectable		 3d2tA-2af5A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS
(Borreliella
burgdorferi) 		3 / 3 ARG A 185
ASP A 164
ASP A 187
 None
 0.86A 3jb2A-2af5A:
undetectable		 3jb2A-2af5A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS
(Borreliella
burgdorferi) 		3 / 3 ARG A 185
ASP A 164
ASP A 187
 None
 0.89A 3jb3A-2af5A:
undetectable		 3jb3A-2af5A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS
(Borreliella
burgdorferi) 		4 / 8 ILE A 289
PHE A 283
GLU A 228
LEU A 311
 None
 0.87A 3ua5A-2af5A:
undetectable		 3ua5A-2af5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS
(Borreliella
burgdorferi) 		4 / 8 LYS A 279
LEU A 281
LEU A 269
VAL A 273
 None
 0.87A 4iizB-2af5A:
undetectable		 4iizB-2af5A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS
(Borreliella
burgdorferi) 		4 / 8 LYS A 279
LEU A 281
LEU A 269
VAL A 273
 None
 0.86A 4ik6B-2af5A:
undetectable		 4ik6B-2af5A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS
(Borreliella
burgdorferi) 		4 / 7 SER A 121
LEU A  88
LEU A  99
THR A 115
 None
 0.84A 4ikkA-2af5A:
undetectable
4ikkB-2af5A:
undetectable		 4ikkA-2af5A:
19.39
4ikkB-2af5A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS
(Borreliella
burgdorferi) 		4 / 6 LYS A 279
LEU A 281
LEU A 269
VAL A 273
 None
 0.93A 5a6iA-2af5A:
undetectable		 5a6iA-2af5A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS
(Borreliella
burgdorferi) 		5 / 12 THR A 222
THR A 223
SER A 201
GLY A 202
ALA A 204
 None
 1.34A 5l5zV-2af5A:
undetectable
5l5zb-2af5A:
undetectable		 5l5zV-2af5A:
21.21
5l5zb-2af5A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS
(Borreliella
burgdorferi) 		5 / 12 THR A 222
THR A 223
SER A 201
GLY A 202
ALA A 204
 None
 1.33A 5l5zH-2af5A:
undetectable
5l5zN-2af5A:
undetectable		 5l5zH-2af5A:
21.21
5l5zN-2af5A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS
(Borreliella
burgdorferi) 		6 / 12 THR A 218
THR A 222
THR A 223
SER A 201
GLY A 202
ALA A 204
 None
 1.49A 5lf7V-2af5A:
2.1
5lf7b-2af5A:
undetectable		 5lf7V-2af5A:
21.74
5lf7b-2af5A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS
(Borreliella
burgdorferi) 		6 / 12 THR A 218
THR A 222
THR A 223
SER A 201
GLY A 202
ALA A 204
 None
 1.49A 5lf7H-2af5A:
2.1
5lf7N-2af5A:
undetectable		 5lf7H-2af5A:
21.74
5lf7N-2af5A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS
(Borreliella
burgdorferi) 		4 / 8 VAL A  32
GLY A  74
LEU A  76
THR A  89
 None
 0.98A 5sxqA-2af5A:
undetectable		 5sxqA-2af5A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS
(Borreliella
burgdorferi) 		4 / 8 VAL A  32
GLY A  74
LEU A  76
THR A  89
 None
 1.03A 5sxqB-2af5A:
undetectable		 5sxqB-2af5A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS
(Borreliella
burgdorferi) 		4 / 8 VAL A  32
GLY A  74
LEU A  76
THR A  89
 None
 0.99A 5syjA-2af5A:
undetectable		 5syjA-2af5A:
18.17