SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2afb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 LEU A 171
GLY A  32
GLY A  33
ASN A  37
LEU A 139
ASP A 280
 None
 1.06A 1bx4A-2afbA:
30.3		 1bx4A-2afbA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		4 / 7 PHE A 118
ALA A 154
VAL A 159
TYR A  77
 None
 0.90A 1epbA-2afbA:
undetectable		 1epbA-2afbA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		4 / 8 PHE A 118
ALA A 154
VAL A 159
TYR A  77
 None
 0.86A 1epbB-2afbA:
undetectable		 1epbB-2afbA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		4 / 8 GLU A  35
LEU A 147
ALA A 150
LEU A 151
 None
 0.91A 1hwiD-2afbA:
undetectable		 1hwiD-2afbA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 LEU A 171
GLY A  32
GLY A  33
ASN A  37
LEU A 139
ASP A 280
 None
 1.04A 1liiA-2afbA:
27.5		 1liiA-2afbA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 LEU A 171
GLY A  32
GLY A  33
ASN A  37
ASP A 280
 None
 1.03A 1likA-2afbA:
29.1		 1likA-2afbA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 325
ILE A 322
MET A 292
LEU A  47
HIS A  -1
 None
 1.18A 1xzxX-2afbA:
undetectable		 1xzxX-2afbA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 LEU A  68
GLU A  35
GLY A   7
ASP A 117
ALA A 109
 None
 1.32A 2bm9B-2afbA:
2.5		 2bm9B-2afbA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 11 ALA A 306
ALA A 305
LEU A 328
SER A 321
LEU A 320
 None
 1.11A 2bxeB-2afbA:
undetectable		 2bxeB-2afbA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLY A 277
ASP A 280
 None
 0.40A 2pkkA-2afbA:
27.0		 2pkkA-2afbA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLY A 277
ASP A 280
 None
 0.40A 2pkmA-2afbA:
26.8		 2pkmA-2afbA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A 134
GLY A   7
THR A  53
LYS A  54
GLU A   8
ASP A 117
 None
 1.38A 2pxcA-2afbA:
undetectable		 2pxcA-2afbA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A 134
GLY A   7
THR A  53
LYS A  54
GLU A   8
ILE A 146
 None
 1.26A 2pxcA-2afbA:
undetectable		 2pxcA-2afbA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		4 / 8 MET A  10
ARG A 168
VAL A 276
GLY A 277
 None
 1.03A 2qd3A-2afbA:
undetectable		 2qd3A-2afbA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 10 THR A 240
SER A 133
ASN A  37
GLY A 279
ALA A 283
 None
 1.42A 2x2iB-2afbA:
0.2		 2x2iB-2afbA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 313
PHE A  51
PHE A 118
ALA A 113
ALA A 109
 None
 1.40A 2x2nD-2afbA:
undetectable		 2x2nD-2afbA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		4 / 8 TYR A 268
ARG A 275
ILE A 270
SER A 265
 None
 1.02A 2xytE-2afbA:
undetectable		 2xytE-2afbA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		4 / 8 TYR A 268
ARG A 275
ILE A 270
SER A 265
 None
 1.01A 2xytH-2afbA:
undetectable		 2xytH-2afbA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		4 / 6 THR A 160
ILE A 287
SER A 290
LEU A 291
 None
 0.88A 3deuB-2afbA:
undetectable		 3deuB-2afbA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		4 / 8 GLY A  32
ILE A 110
PHE A 132
PHE A 130
 None
 1.04A 3ko0B-2afbA:
undetectable
3ko0J-2afbA:
0.0		 3ko0B-2afbA:
16.99
3ko0J-2afbA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		3 / 3 LYS A 299
VAL A 256
HIS A 263
 None
 1.23A 3tj7A-2afbA:
undetectable		 3tj7A-2afbA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A  32
GLY A  33
ASN A  37
GLU A  35
GLY A 277
ASP A 280
 None
 0.78A 3uboA-2afbA:
32.0		 3uboA-2afbA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLU A  35
ASP A 280
 None
 1.01A 3uboB-2afbA:
32.7		 3uboB-2afbA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 LEU A 171
GLY A  32
GLY A  33
ASN A  37
GLY A 277
ASP A 280
 None
 0.95A 3uq6A-2afbA:
27.7		 3uq6A-2afbA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 LEU A 171
GLY A  33
ASN A  37
LEU A 139
GLY A 277
ASP A 280
 None
 1.07A 3uq6A-2afbA:
27.7		 3uq6A-2afbA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		7 / 12 LEU A 171
GLY A  33
ALA A  34
ASN A  37
LEU A 139
GLY A 277
ASP A 280
 None
 1.03A 3uq6B-2afbA:
29.7		 3uq6B-2afbA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 LEU A 171
GLY A  32
GLY A  33
ASN A  37
GLY A 277
ASP A 280
 None
 0.93A 3vaqA-2afbA:
30.8		 3vaqA-2afbA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 LEU A 171
GLY A  33
ASN A  37
LEU A 139
GLY A 277
ASP A 280
 None
 1.05A 3vaqA-2afbA:
30.8		 3vaqA-2afbA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		7 / 12 LEU A 171
GLY A  33
ALA A  34
ASN A  37
LEU A 139
GLY A 277
ASP A 280
 None
 1.01A 3vaqB-2afbA:
29.3		 3vaqB-2afbA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 LEU A 171
GLY A  32
GLY A  33
ASN A  37
GLY A 277
ASP A 280
 None
 0.92A 3vasA-2afbA:
27.4		 3vasA-2afbA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 LEU A 171
GLY A  33
ASN A  37
LEU A 139
GLY A 277
ASP A 280
 None
 1.04A 3vasA-2afbA:
27.4		 3vasA-2afbA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 LEU A 171
GLY A  32
GLY A  33
ASN A  37
GLY A 277
ASP A 280
 None
 0.87A 3vasB-2afbA:
22.5		 3vasB-2afbA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 LEU A 171
GLY A  33
ASN A  37
LEU A 139
GLY A 277
ASP A 280
 None
 1.01A 3vasB-2afbA:
22.5		 3vasB-2afbA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A 134
GLY A   7
THR A  53
LYS A  54
GLU A   8
ILE A 146
 None
 1.46A 4ctkA-2afbA:
undetectable		 4ctkA-2afbA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		7 / 12 LEU A 171
GLY A  32
ALA A  34
ASN A  37
LEU A 139
GLY A 277
ASP A 280
 None
 1.07A 4dc3A-2afbA:
28.9		 4dc3A-2afbA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		7 / 12 LEU A 171
GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLY A 277
ASP A 280
 None
 1.02A 4dc3B-2afbA:
27.4		 4dc3B-2afbA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLU A  35
ASP A 280
 None
 0.99A 4e3aA-2afbA:
33.2		 4e3aA-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		7 / 12 GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLU A  35
GLY A 277
ASP A 280
 None
 0.91A 4e3aB-2afbA:
33.4		 4e3aB-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		4 / 7 ALA A 306
GLY A 289
ILE A 287
GLY A 284
 None
 0.61A 4eatA-2afbA:
undetectable		 4eatA-2afbA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		4 / 5 GLY A  82
GLY A  81
ASN A  57
GLU A 112
 None
 1.26A 4fglC-2afbA:
4.2		 4fglC-2afbA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		3 / 3 LYS A 299
LEU A 286
ALA A 300
 None
 0.70A 4ikiA-2afbA:
undetectable		 4ikiA-2afbA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLU A  35
ASP A 280
 None
 0.70A 4jksA-2afbA:
33.1		 4jksA-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLU A  35
ASP A 280
 None
 0.69A 4jksB-2afbA:
33.1		 4jksB-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLU A  35
ASP A 280
 None
 0.68A 4jkuA-2afbA:
33.0		 4jkuA-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLU A  35
ASP A 280
 None
 0.99A 4jkuB-2afbA:
33.0		 4jkuB-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLU A  35
ASP A 280
 None
 0.70A 4k8cA-2afbA:
33.0		 4k8cA-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLU A  35
ASP A 280
 None
 0.69A 4k8cB-2afbA:
33.1		 4k8cB-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLU A  35
ASP A 280
 None
 0.70A 4k8kA-2afbA:
33.1		 4k8kA-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLU A  35
ASP A 280
 None
 0.69A 4k8kB-2afbA:
33.1		 4k8kB-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLU A  35
ASP A 280
 None
 0.99A 4k8pA-2afbA:
33.1		 4k8pA-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLU A  35
ASP A 280
 None
 0.99A 4k8pB-2afbA:
33.0		 4k8pB-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLU A  35
ASP A 280
 None
 0.97A 4k8tA-2afbA:
33.0		 4k8tA-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLU A  35
ASP A 280
 None
 1.00A 4k8tB-2afbA:
33.0		 4k8tB-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLU A  35
ASP A 280
 None
 0.98A 4k93A-2afbA:
33.0		 4k93A-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLU A  35
ASP A 280
 None
 0.97A 4k93B-2afbA:
33.1		 4k93B-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLU A  35
ASP A 280
 None
 0.99A 4k9cA-2afbA:
33.0		 4k9cA-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLU A  35
ASP A 280
 None
 0.98A 4k9cB-2afbA:
33.0		 4k9cB-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLU A  35
ASP A 280
 None
 0.98A 4k9iA-2afbA:
32.9		 4k9iA-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLU A  35
ASP A 280
 None
 0.99A 4k9iB-2afbA:
33.0		 4k9iB-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLU A  35
ASP A 280
 None
 1.00A 4kadA-2afbA:
33.1		 4kadA-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLU A  35
ASP A 280
 None
 1.00A 4kadB-2afbA:
30.6		 4kadB-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLU A  35
ASP A 280
 None
 0.69A 4kahA-2afbA:
33.0		 4kahA-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLU A  35
ASP A 280
 None
 0.70A 4kahB-2afbA:
33.1		 4kahB-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLU A  35
ASP A 280
 None
 0.69A 4kalA-2afbA:
33.0		 4kalA-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLU A  35
ASP A 280
 None
 0.70A 4kalB-2afbA:
32.9		 4kalB-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLU A  35
ASP A 280
 None
 0.70A 4kanA-2afbA:
33.0		 4kanA-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLU A  35
ASP A 280
 None
 0.70A 4kanB-2afbA:
33.1		 4kanB-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLU A  35
ASP A 280
 None
 0.70A 4kbeA-2afbA:
33.0		 4kbeA-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLU A  35
ASP A 280
 None
 0.70A 4kbeB-2afbA:
33.0		 4kbeB-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		4 / 5 LEU A 143
PRO A 137
LEU A 139
ILE A 110
 None
 0.93A 4klrA-2afbA:
2.0		 4klrA-2afbA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLU A  35
ASP A 280
 None
 0.70A 4lbgA-2afbA:
33.0		 4lbgA-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLU A  35
ASP A 280
 None
 0.70A 4lbgB-2afbA:
33.1		 4lbgB-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLU A  35
ASP A 280
 None
 1.00A 4lbxA-2afbA:
33.0		 4lbxA-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLU A  35
ASP A 280
 None
 1.01A 4lbxB-2afbA:
33.1		 4lbxB-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLU A  35
ASP A 280
 None
 1.00A 4lc4A-2afbA:
33.0		 4lc4A-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLU A  35
ASP A 280
 None
 1.00A 4lc4B-2afbA:
33.0		 4lc4B-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLU A  35
ASP A 280
 None
 0.71A 4lcaA-2afbA:
33.1		 4lcaA-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  32
GLY A  33
ASN A  37
GLU A  35
ASP A 280
 None
 0.68A 4lcaB-2afbA:
33.1		 4lcaB-2afbA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 LEU A 171
GLY A  33
ASN A  37
GLY A 277
ASP A 280
 None
 1.05A 4n09A-2afbA:
30.8		 4n09A-2afbA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 LEU A 171
GLY A  32
GLY A  33
ASN A  37
ASP A 280
 None
 0.88A 4n09B-2afbA:
30.7		 4n09B-2afbA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		7 / 12 LEU A 171
GLY A  32
GLY A  33
ASN A  37
LEU A 139
GLY A 277
ASP A 280
 None
 1.09A 4n09C-2afbA:
30.8		 4n09C-2afbA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 LEU A 171
GLY A  33
ASN A  37
LEU A 139
GLY A 279
ASP A 280
 None
 1.43A 4n09C-2afbA:
30.8		 4n09C-2afbA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 LEU A 171
GLY A  32
GLY A  33
ASN A  37
GLY A 277
ASP A 280
 None
 1.07A 4n09D-2afbA:
30.6		 4n09D-2afbA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		4 / 4 ALA A  36
ALA A  39
ALA A  40
ALA A  43
 None
 0.13A 4oadA-2afbA:
0.2		 4oadA-2afbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		4 / 4 ALA A  36
ALA A  39
ALA A  40
ALA A  43
 None
 0.11A 4oaeA-2afbA:
0.1		 4oaeA-2afbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		4 / 8 PHE A  51
ARG A  69
ALA A  65
LEU A  68
 None
 0.87A 4rkuA-2afbA:
undetectable
4rkuJ-2afbA:
undetectable		 4rkuA-2afbA:
18.92
4rkuJ-2afbA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		4 / 7 GLY A  33
ARG A 105
ALA A  34
ILE A 135
 None
 0.96A 4txnA-2afbA:
undetectable		 4txnA-2afbA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		4 / 7 PHE A  51
ARG A  69
ALA A  65
LEU A  68
 None
 0.89A 4xk8A-2afbA:
undetectable		 4xk8A-2afbA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 LEU A 202
LEU A 165
ILE A 198
ILE A 239
VAL A 237
 None
 0.96A 4y0sA-2afbA:
undetectable		 4y0sA-2afbA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		4 / 6 LEU A  55
ASN A  58
PRO A  56
ARG A 105
 None
 1.43A 4yv5B-2afbA:
undetectable		 4yv5B-2afbA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A 134
GLY A   7
THR A  53
LYS A  54
GLU A   8
ASP A 117
 None
 1.49A 5e9qC-2afbA:
undetectable		 5e9qC-2afbA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A 134
GLY A   7
THR A  53
LYS A  54
GLU A   8
ILE A 146
 None
 1.45A 5e9qC-2afbA:
undetectable		 5e9qC-2afbA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 10 ALA A  40
GLY A  33
THR A   5
HIS A 131
ILE A   9
 None
 1.18A 5eeuF-2afbA:
undetectable
5eeuG-2afbA:
undetectable		 5eeuF-2afbA:
13.24
5eeuG-2afbA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 10 ALA A  40
GLY A  33
THR A   5
HIS A 131
ILE A   9
 None
 1.18A 5eevF-2afbA:
undetectable
5eevG-2afbA:
undetectable		 5eevF-2afbA:
13.24
5eevG-2afbA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 10 ALA A  40
GLY A  33
THR A   5
HIS A 131
ILE A   9
 None
 1.18A 5eewF-2afbA:
undetectable
5eewG-2afbA:
undetectable		 5eewF-2afbA:
13.24
5eewG-2afbA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 10 ALA A  40
GLY A  33
THR A   5
HIS A 131
ILE A   9
 None
 1.18A 5eexF-2afbA:
undetectable
5eexG-2afbA:
undetectable		 5eexF-2afbA:
13.24
5eexG-2afbA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 10 ALA A  40
GLY A  33
THR A   5
HIS A 131
ILE A   9
 None
 1.18A 5eeyF-2afbA:
undetectable
5eeyG-2afbA:
undetectable		 5eeyF-2afbA:
13.24
5eeyG-2afbA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 10 ALA A  40
GLY A  33
THR A   5
HIS A 131
ILE A   9
 None
 1.19A 5eezF-2afbA:
undetectable
5eezG-2afbA:
undetectable		 5eezF-2afbA:
13.24
5eezG-2afbA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 10 ALA A  40
GLY A  33
THR A   5
HIS A 131
ILE A   9
 None
 1.18A 5ef0F-2afbA:
undetectable
5ef0G-2afbA:
undetectable		 5ef0F-2afbA:
13.24
5ef0G-2afbA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 10 ALA A  40
GLY A  33
THR A   5
HIS A 131
ILE A   9
 None
 1.19A 5ef1F-2afbA:
undetectable
5ef1G-2afbA:
undetectable		 5ef1F-2afbA:
13.24
5ef1G-2afbA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 10 ALA A  40
GLY A  33
THR A   5
HIS A 131
ILE A   9
 None
 1.19A 5ef2F-2afbA:
undetectable
5ef2G-2afbA:
undetectable		 5ef2F-2afbA:
13.24
5ef2G-2afbA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 10 ALA A  40
GLY A  33
THR A   5
HIS A 131
ILE A   9
 None
 1.19A 5ef3F-2afbA:
undetectable
5ef3G-2afbA:
undetectable		 5ef3F-2afbA:
13.24
5ef3G-2afbA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A 134
GLY A   7
THR A  53
LYS A  54
GLU A   8
ASP A 117
 None
 1.50A 5eiwC-2afbA:
undetectable		 5eiwC-2afbA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A 134
GLY A   7
THR A  53
LYS A  54
GLU A   8
ILE A 146
 None
 1.36A 5eiwC-2afbA:
undetectable		 5eiwC-2afbA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		4 / 8 GLY A   7
THR A 136
LEU A 147
LEU A 151
 None
 0.82A 5hs1A-2afbA:
undetectable		 5hs1A-2afbA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		4 / 6 ILE A 198
VAL A 237
TYR A 232
VAL A 228
 None
 0.94A 5jwaH-2afbA:
undetectable		 5jwaH-2afbA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 LEU A 171
GLY A  32
GLY A  33
ASN A  37
GLY A 277
ASP A 280
 None
 0.94A 5kb5A-2afbA:
30.5		 5kb5A-2afbA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 LEU A 171
GLY A  33
ASN A  37
LEU A 139
GLY A 277
ASP A 280
 None
 1.05A 5kb5A-2afbA:
30.5		 5kb5A-2afbA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		6 / 12 GLY A 134
GLY A   7
THR A  53
LYS A  54
GLU A   8
ILE A 146
 None
 1.30A 5wz1B-2afbA:
2.8		 5wz1B-2afbA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 10 TYR A  31
PHE A 317
ALA A  40
THR A  53
LEU A  55
 None
 1.13A 6ay4A-2afbA:
undetectable		 6ay4A-2afbA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 9 TYR A  31
PHE A 317
ALA A  40
THR A  53
LEU A  55
 None
 1.29A 6ay6A-2afbA:
undetectable		 6ay6A-2afbA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 TYR A  31
PHE A 317
PHE A  89
ALA A  40
THR A  53
 None
 1.10A 6aybA-2afbA:
undetectable		 6aybA-2afbA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 TYR A  31
PHE A 317
ALA A  40
THR A  53
LEU A  55
 None
 1.35A 6aycA-2afbA:
undetectable		 6aycA-2afbA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE
(Thermotoga
maritima) 		5 / 12 HIS A  -4
GLY A  46
HIS A  -1
MET A 292
PHE A 294
 CA  A 344 (-3.3A)
None
None
None
None
 1.26A 6exiD-2afbA:
5.0		 6exiD-2afbA:
14.45