SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aff'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 2aff ANTIGEN KI-67
MKI67 FHA DOMAIN
INTERACTING
NUCLEOLAR
PHOSPHOPROTEIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 GLU B 260
ASP B 256
ASP A  92
 None
 0.70A 3jb2A-2affB:
undetectable		 3jb2A-2affB:
4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 2aff ANTIGEN KI-67
MKI67 FHA DOMAIN
INTERACTING
NUCLEOLAR
PHOSPHOPROTEIN
(Homo
sapiens) 		4 / 5 LEU A  22
ILE A  37
LYS B 264
GLN B 265
 None
 1.09A 4ma8C-2affA:
undetectable		 4ma8C-2affA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 2aff ANTIGEN KI-67
(Homo
sapiens) 		3 / 3 CYH A  49
LYS A  50
HIS A  61
 None
 0.91A 5js5A-2affA:
undetectable		 5js5A-2affA:
19.86