SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2afg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RLF_B_RIMB299_1 (MATRIX PROTEIN 2)	2afg	ACIDIC FIBROBLAST GROWTH FACTOR (Homo sapiens)	4 / 6	LEU A 23 LEU A 111 ILE A 25 ARG A 24	None	1.16A	2rlfB-2afgA: undetectable 2rlfC-2afgA: undetectable	2rlfB-2afgA: 16.96 2rlfC-2afgA: 16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7W_A_SALA1300_1 (LYSR-TYPE REGULATORY PROTEIN)	2afg	ACIDIC FIBROBLAST GROWTH FACTOR (Homo sapiens)	5 / 9	THR A 123 ILE A 130 TYR A 125 ARG A 88 ILE A 98	None	1.47A	2y7wA-2afgA: undetectable	2y7wA-2afgA: 20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OZW_A_KKKA413_1 (FLAVOHEMOGLOBIN)	2afg	ACIDIC FIBROBLAST GROWTH FACTOR (Homo sapiens)	4 / 8	ILE A 25 GLN A 77 ALA A 66 LEU A 65	None	0.87A	3ozwA-2afgA: undetectable	3ozwA-2afgA: 17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J7U_D_YTZD802_1 (SEPIAPTERIN REDUCTASE)	2afg	ACIDIC FIBROBLAST GROWTH FACTOR (Homo sapiens)	4 / 8	LEU A 111 CYH A 16 PHE A 132 GLN A 127	None	1.09A	4j7uD-2afgA: undetectable	4j7uD-2afgA: 20.77

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2RLF_B_RIMB299_1","MATRIX PROTEIN 2;MATRIX PROTEIN 2","2afg","ACIDIC FIBROBLAST GROWTH FACTOR","Homo sapiens",4,"LEU A  23;LEU A 111;ILE A  25;ARG A  24","None","1.16A","2rlfB-2afgA:undetectable;2rlfC-2afgA:undetectable","2rlfB-2afgA:16.96;2rlfC-2afgA:16.96"],["2Y7W_A_SALA1300_1","LYSR-TYPE REGULATORY PROTEIN","2afg","ACIDIC FIBROBLAST GROWTH FACTOR","Homo sapiens",5,"THR A 123;ILE A 130;TYR A 125;ARG A  88;ILE A  98","None","1.47A","2y7wA-2afgA:undetectable","2y7wA-2afgA:20.28"],["3OZW_A_KKKA413_1","FLAVOHEMOGLOBIN","2afg","ACIDIC FIBROBLAST GROWTH FACTOR","Homo sapiens",4,"ILE A  25;GLN A  77;ALA A  66;LEU A  65","None","0.87A","3ozwA-2afgA:undetectable","3ozwA-2afgA:17.09"],["4J7U_D_YTZD802_1","SEPIAPTERIN REDUCTASE","2afg","ACIDIC FIBROBLAST GROWTH FACTOR","Homo sapiens",4,"LEU A 111;CYH A  16;PHE A 132;GLN A 127","None","1.09A","4j7uD-2afgA:undetectable","4j7uD-2afgA:20.77"]]