SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2afh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		3 / 3 THR B 325
LEU B 329
VAL B 332
 None
 0.66A 1mz9E-2afhB:
undetectable		 1mz9E-2afhB:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		3 / 3 ASN B  65
ALA B  67
ASN B 445
 None
 0.77A 1n4fA-2afhB:
undetectable		 1n4fA-2afhB:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		5 / 11 ALA B 368
ILE B 501
VAL B 434
LEU B 379
THR B 496
 None
 1.18A 1rv7A-2afhB:
undetectable
1rv7B-2afhB:
undetectable		 1rv7A-2afhB:
12.60
1rv7B-2afhB:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		5 / 12 LEU B 316
SER B 336
VAL B 332
PHE B 328
ILE B 240
 None
 1.40A 1uobA-2afhB:
undetectable		 1uobA-2afhB:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		4 / 7 SER B 255
PHE B 201
GLY B 203
ILE B 166
 None
 1.03A 2bdmA-2afhB:
undetectable		 2bdmA-2afhB:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		4 / 6 HIS B 297
GLU B 231
PHE B 237
PRO B 257
 None
 1.09A 2qqtA-2afhB:
undetectable		 2qqtA-2afhB:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		4 / 4 SER B 336
GLY B 337
GLY B 250
GLY B 248
 None
 0.78A 3bogB-2afhB:
undetectable
3bogD-2afhB:
undetectable		 3bogB-2afhB:
undetectable
3bogD-2afhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		5 / 12 HIS B 193
GLY B 470
ASP B 372
ILE B 443
VAL B 376
 None
 0.97A 3bwcB-2afhB:
3.4		 3bwcB-2afhB:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		5 / 12 HIS B 193
ILE B 473
GLY B 470
ASP B 372
VAL B 376
 None
 0.93A 3bwcB-2afhB:
3.4		 3bwcB-2afhB:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		4 / 5 ASP B 256
ILE B 240
VAL B 291
THR B 301
 None
 1.23A 3eigA-2afhB:
undetectable		 3eigA-2afhB:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		3 / 3 VAL B 434
LYS B 438
HIS B 457
 None
1PE  B5017 (-4.9A)
None
 0.95A 3elzA-2afhB:
undetectable		 3elzA-2afhB:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		4 / 6 HIS B 297
GLU B 231
PHE B 237
PRO B 257
 None
 1.24A 3gclA-2afhB:
undetectable		 3gclA-2afhB:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		4 / 5 ASP B 116
SER B 115
VAL B  96
GLY B  91
 None
 1.04A 3rxhA-2afhB:
undetectable		 3rxhA-2afhB:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		4 / 7 ALA B 490
TYR B 487
ARG B 350
ARG B 242
 None
 1.05A 3twpC-2afhB:
3.2		 3twpC-2afhB:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		3 / 3 GLN B 136
THR B 141
ASN B 137
 None
 0.78A 3v4tE-2afhB:
undetectable		 3v4tE-2afhB:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		4 / 8 LEU B 479
ILE B 473
ASN B 445
GLY B 444
 None
 0.86A 3wxoA-2afhB:
undetectable		 3wxoA-2afhB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		4 / 7 THR B 209
HIS B 311
ASN B 225
LEU B 254
 None
 1.34A 4awuA-2afhB:
undetectable		 4awuA-2afhB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		5 / 12 HIS B 396
GLY B 371
GLY B 444
ASP B 372
GLY B 424
 None
 0.87A 4blvA-2afhB:
3.2		 4blvA-2afhB:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		4 / 5 ARG B 242
MET B 247
GLU B 246
LEU B 329
 None
 1.33A 4hojA-2afhB:
undetectable		 4hojA-2afhB:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		4 / 9 TYR B 102
PHE B 230
HIS B 193
ILE B 473
 None
 1.08A 4jvlA-2afhB:
2.8		 4jvlA-2afhB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		3 / 3 LEU B  14
ASP B  17
TYR B  20
 None
 0.57A 4qc6B-2afhB:
undetectable		 4qc6B-2afhB:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		5 / 12 TRP B 370
ASP B 372
HIS B 297
GLN B 294
ILE B 318
 None
 1.17A 4ynmA-2afhB:
undetectable		 4ynmA-2afhB:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		5 / 12 TRP B 370
ASP B 372
HIS B 297
GLN B 294
ILE B 318
 None
 1.15A 4ynmB-2afhB:
undetectable		 4ynmB-2afhB:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		5 / 12 GLY B 470
TRP B 370
ASP B 372
GLN B 294
ILE B 318
 None
 1.38A 4ypaB-2afhB:
undetectable		 4ypaB-2afhB:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		5 / 12 TRP B 370
ASP B 372
HIS B 297
GLN B 294
ILE B 318
 None
 1.21A 4ypaC-2afhB:
undetectable		 4ypaC-2afhB:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		4 / 7 MET B 213
GLY B 219
ASN B 286
HIS B 311
 None
 1.23A 5a5zC-2afhB:
undetectable		 5a5zC-2afhB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		4 / 5 PHE B 375
ILE B 443
GLY B 371
ILE B 469
 None
 0.83A 5dzkB-2afhB:
undetectable
5dzkI-2afhB:
undetectable
5dzkW-2afhB:
undetectable		 5dzkB-2afhB:
16.70
5dzkI-2afhB:
16.54
5dzkW-2afhB:
0.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		4 / 5 PHE B 375
ILE B 443
GLY B 371
ILE B 469
 None
 0.80A 5dzkd-2afhB:
undetectable
5dzkk-2afhB:
undetectable
5dzky-2afhB:
undetectable		 5dzkd-2afhB:
16.70
5dzkk-2afhB:
16.54
5dzky-2afhB:
0.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		4 / 5 GLY B  81
PRO B 180
GLN B 278
THR B 276
 None
 1.17A 5h5fA-2afhB:
undetectable		 5h5fA-2afhB:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		5 / 12 ILE B 443
LEU B 497
GLY B 470
HIS B 106
GLY B 444
 None
 1.02A 5l6eA-2afhB:
2.2		 5l6eA-2afhB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		5 / 12 LEU B 497
SER B 482
GLY B 470
HIS B 106
GLY B 444
 None
 0.94A 5l6eA-2afhB:
2.2		 5l6eA-2afhB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		4 / 8 GLY B  74
ASP B 372
PHE B 230
PHE B 103
 None
 0.98A 5mvsB-2afhB:
3.8		 5mvsB-2afhB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		3 / 3 ALA B 273
GLN B 268
THR B 263
 None
 0.74A 5n0oA-2afhB:
2.4		 5n0oA-2afhB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		4 / 5 ASP B 372
GLY B 470
TRP B 370
CYH B 395
 None
 1.39A 5nn8A-2afhB:
undetectable		 5nn8A-2afhB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		5 / 12 GLY B 489
LEU B 383
LEU B 384
GLU B 385
LEU B 386
 None
 0.98A 5nwwA-2afhB:
undetectable		 5nwwA-2afhB:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		4 / 6 ASN B 286
ALA B 287
VAL B 218
ASP B 283
 None
None
TRS  B5003 (-4.6A)
None
 1.19A 5umd2-2afhB:
undetectable
5umdF-2afhB:
undetectable		 5umd2-2afhB:
10.23
5umdF-2afhB:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		5 / 11 SER B 150
THR B 151
LEU B 135
ALA B 155
VAL B 114
 None
 1.31A 6dryA-2afhB:
undetectable		 6dryA-2afhB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		5 / 11 VAL B 149
SER B 150
THR B 151
LEU B 135
VAL B 114
 None
 1.35A 6dryA-2afhB:
undetectable		 6dryA-2afhB:
21.96