SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2afv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 2afv COBALAMIN
BIOSYNTHESIS
PRECORRIN ISOMERASE
(Leptospira
interrogans) 		5 / 11 ILE A 194
GLY A 165
ILE A 139
PRO A 160
ILE A 136
 None
 0.95A 1c6yA-2afvA:
undetectable		 1c6yA-2afvA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 2afv COBALAMIN
BIOSYNTHESIS
PRECORRIN ISOMERASE
(Leptospira
interrogans) 		5 / 9 ILE A 194
GLY A 165
ILE A 139
PRO A 160
ILE A 136
 None
 0.91A 2avoA-2afvA:
undetectable		 2avoA-2afvA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 2afv COBALAMIN
BIOSYNTHESIS
PRECORRIN ISOMERASE
(Leptospira
interrogans) 		5 / 9 ILE A 194
GLY A 165
ILE A 139
PRO A 160
ILE A 136
 None
 0.91A 3d1yB-2afvA:
undetectable		 3d1yB-2afvA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 2afv COBALAMIN
BIOSYNTHESIS
PRECORRIN ISOMERASE
(Leptospira
interrogans) 		5 / 9 ILE A 194
GLY A 165
ILE A 139
PRO A 160
ILE A 136
 None
 0.88A 3ekqB-2afvA:
undetectable		 3ekqB-2afvA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 2afv COBALAMIN
BIOSYNTHESIS
PRECORRIN ISOMERASE
(Leptospira
interrogans) 		5 / 11 ILE A 194
GLY A 165
ILE A 139
PRO A 160
ILE A 136
 None
 0.96A 3ekxB-2afvA:
undetectable		 3ekxB-2afvA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 2afv COBALAMIN
BIOSYNTHESIS
PRECORRIN ISOMERASE
(Leptospira
interrogans) 		5 / 12 LEU A 210
GLY A 165
VAL A  38
ILE A  57
ILE A 209
 None
 1.07A 3nu5B-2afvA:
undetectable		 3nu5B-2afvA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2afv COBALAMIN
BIOSYNTHESIS
PRECORRIN ISOMERASE
(Leptospira
interrogans) 		4 / 6 ASN A 127
GLN A 155
LEU A 152
GLU A 150
 None
 1.26A 4nc3A-2afvA:
undetectable		 4nc3A-2afvA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 2afv COBALAMIN
BIOSYNTHESIS
PRECORRIN ISOMERASE
(Leptospira
interrogans) 		4 / 8 ILE A 149
ILE A 123
ASN A 127
ALA A 126
 None
 0.92A 4ou1A-2afvA:
2.1		 4ou1A-2afvA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 2afv COBALAMIN
BIOSYNTHESIS
PRECORRIN ISOMERASE
(Leptospira
interrogans) 		5 / 12 SER A 176
GLU A 150
ARG A 154
ILE A 149
ILE A 123
 None
 1.25A 4uroD-2afvA:
undetectable		 4uroD-2afvA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 2afv COBALAMIN
BIOSYNTHESIS
PRECORRIN ISOMERASE
(Leptospira
interrogans) 		5 / 9 ILE A 194
GLY A 165
ILE A 139
PRO A 160
ILE A 136
 None
 0.89A 5kqxB-2afvA:
undetectable		 5kqxB-2afvA:
19.03