SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ag5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ag5 DEHYDROGENASE/REDUCT
ASE (SDR FAMILY)
MEMBER 6
(Homo
sapiens) 		5 / 12 SER A 184
PHE A 100
LEU A 104
VAL A  59
ALA A  13
 NAD  A2001 (-2.8A)
None
NAD  A2001 (-4.6A)
NAD  A2001 (-3.8A)
NAD  A2001 (-3.2A)
 1.38A 1q23D-2ag5A:
undetectable
1q23E-2ag5A:
undetectable		 1q23D-2ag5A:
22.89
1q23E-2ag5A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2ag5 DEHYDROGENASE/REDUCT
ASE (SDR FAMILY)
MEMBER 6
(Homo
sapiens) 		6 / 10 ASP A  37
ILE A  38
ASN A  39
ALA A  15
ASP A  58
VAL A  59
 NAD  A2001 (-2.9A)
NAD  A2001 (-3.9A)
None
NAD  A2001 ( 3.7A)
NAD  A2001 (-3.4A)
NAD  A2001 (-3.8A)
 0.96A 3ay0A-2ag5A:
6.2		 3ay0A-2ag5A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2ag5 DEHYDROGENASE/REDUCT
ASE (SDR FAMILY)
MEMBER 6
(Homo
sapiens) 		5 / 10 ASP A  37
ILE A  38
ASN A  39
ASP A  58
VAL A  59
 NAD  A2001 (-2.9A)
NAD  A2001 (-3.9A)
None
NAD  A2001 (-3.4A)
NAD  A2001 (-3.8A)
 0.62A 3ay0B-2ag5A:
6.5		 3ay0B-2ag5A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ag5 DEHYDROGENASE/REDUCT
ASE (SDR FAMILY)
MEMBER 6
(Homo
sapiens) 		5 / 7 LEU A 185
ARG A 210
PRO A 177
SER A 133
GLY A 241
 NAD  A2001 (-4.4A)
None
NAD  A2001 (-3.9A)
NAD  A2001 ( 4.0A)
None
 1.49A 3hcnA-2ag5A:
2.3		 3hcnA-2ag5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 2ag5 DEHYDROGENASE/REDUCT
ASE (SDR FAMILY)
MEMBER 6
(Homo
sapiens) 		4 / 8 TYR A 147
VAL A 138
ILE A  18
GLY A 178
 NAD  A2001 (-4.6A)
None
NAD  A2001 (-3.5A)
None
 0.80A 3hjoA-2ag5A:
undetectable		 3hjoA-2ag5A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2ag5 DEHYDROGENASE/REDUCT
ASE (SDR FAMILY)
MEMBER 6
(Homo
sapiens) 		5 / 12 ILE A  18
GLY A  19
ALA A  82
VAL A  81
ASN A  80
 NAD  A2001 (-3.5A)
None
NAD  A2001 ( 4.5A)
NAD  A2001 (-4.7A)
None
 0.87A 3jb3A-2ag5A:
4.5		 3jb3A-2ag5A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 2ag5 DEHYDROGENASE/REDUCT
ASE (SDR FAMILY)
MEMBER 6
(Homo
sapiens) 		5 / 12 THR A 182
ILE A  18
ASP A  37
ASN A  39
ASP A  58
 NAD  A2001 (-2.9A)
NAD  A2001 (-3.5A)
NAD  A2001 (-2.9A)
None
NAD  A2001 (-3.4A)
 1.17A 3q87B-2ag5A:
7.3		 3q87B-2ag5A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ag5 DEHYDROGENASE/REDUCT
ASE (SDR FAMILY)
MEMBER 6
(Homo
sapiens) 		5 / 8 LEU A 185
ARG A 210
PRO A 177
SER A 133
GLY A 241
 NAD  A2001 (-4.4A)
None
NAD  A2001 (-3.9A)
NAD  A2001 ( 4.0A)
None
 1.46A 4klrB-2ag5A:
3.1		 4klrB-2ag5A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2ag5 DEHYDROGENASE/REDUCT
ASE (SDR FAMILY)
MEMBER 6
(Homo
sapiens) 		3 / 3 LYS A   7
ASP A   5
ILE A  34
 None
 0.80A 5kc4E-2ag5A:
undetectable		 5kc4E-2ag5A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 2ag5 DEHYDROGENASE/REDUCT
ASE (SDR FAMILY)
MEMBER 6
(Homo
sapiens) 		5 / 12 ASP A  37
ILE A  38
ASN A  39
VAL A  59
LEU A 104
 NAD  A2001 (-2.9A)
NAD  A2001 (-3.9A)
None
NAD  A2001 (-3.8A)
NAD  A2001 (-4.6A)
 0.73A 5wy0A-2ag5A:
6.1		 5wy0A-2ag5A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2ag5 DEHYDROGENASE/REDUCT
ASE (SDR FAMILY)
MEMBER 6
(Homo
sapiens) 		3 / 3 PHE A 202
ARG A 188
ALA A 135
 SO4  A5001 (-4.1A)
SO4  A5001 (-3.6A)
None
 0.76A 6ecfB-2ag5A:
4.2		 6ecfB-2ag5A:
21.66