SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ag8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 12 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.34A 1q23B-2ag8A:
undetectable		 1q23B-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 12 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.32A 1q23C-2ag8A:
undetectable		 1q23C-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 10 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.31A 1q23E-2ag8A:
undetectable		 1q23E-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 11 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.33A 1q23F-2ag8A:
undetectable		 1q23F-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		6 / 12 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
VAL A  84
 None
 1.39A 1q23H-2ag8A:
undetectable
1q23I-2ag8A:
undetectable		 1q23H-2ag8A:
18.98
1q23I-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 11 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.37A 1q23I-2ag8A:
undetectable		 1q23I-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 11 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.31A 1q23J-2ag8A:
undetectable		 1q23J-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 10 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.34A 1q23K-2ag8A:
undetectable		 1q23K-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 11 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.33A 1q23L-2ag8A:
undetectable		 1q23L-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		3 / 3 SER A 122
GLY A 146
GLY A 115
 None
 0.56A 3bogA-2ag8A:
undetectable
3bogC-2ag8A:
undetectable		 3bogA-2ag8A:
undetectable
3bogC-2ag8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		4 / 7 VAL A  93
LEU A  96
SER A  97
VAL A  84
 None
 0.72A 3hs6B-2ag8A:
0.6		 3hs6B-2ag8A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 10 PRO A 114
PRO A 168
SER A 164
SER A 122
GLY A 165
 None
None
None
None
NAP  A 311 (-4.2A)
 1.28A 3ijxB-2ag8A:
undetectable
3ijxD-2ag8A:
undetectable		 3ijxB-2ag8A:
22.53
3ijxD-2ag8A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 12 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.42A 3u9fB-2ag8A:
undetectable
3u9fC-2ag8A:
undetectable		 3u9fB-2ag8A:
18.98
3u9fC-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 10 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.36A 3u9fE-2ag8A:
undetectable		 3u9fE-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 12 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.33A 3u9fH-2ag8A:
undetectable
3u9fI-2ag8A:
undetectable		 3u9fH-2ag8A:
18.98
3u9fI-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 10 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.31A 3u9fI-2ag8A:
undetectable		 3u9fI-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 10 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.42A 3u9fK-2ag8A:
undetectable		 3u9fK-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 11 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.40A 3u9fN-2ag8A:
undetectable
3u9fO-2ag8A:
undetectable		 3u9fN-2ag8A:
18.98
3u9fO-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 9 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.37A 3u9fP-2ag8A:
undetectable		 3u9fP-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 12 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.35A 3u9fP-2ag8A:
undetectable
3u9fS-2ag8A:
undetectable		 3u9fP-2ag8A:
18.98
3u9fS-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 8 GLY A 120
GLY A 146
SER A 122
GLY A 123
VAL A 109
 None
 1.21A 3v1nA-2ag8A:
undetectable		 3v1nA-2ag8A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		4 / 8 LEU A  85
VAL A   3
VAL A  15
LEU A  83
 None
 0.95A 3v81C-2ag8A:
undetectable		 3v81C-2ag8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		4 / 8 LEU A  85
VAL A   3
VAL A  15
LEU A  83
 None
 0.94A 4puoC-2ag8A:
undetectable		 4puoC-2ag8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		4 / 8 LEU A  85
VAL A   3
VAL A  15
LEU A  83
 None
 1.01A 4pwdA-2ag8A:
undetectable		 4pwdA-2ag8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		4 / 8 LEU A  85
VAL A   3
VAL A  15
LEU A  83
 None
 0.98A 4q0bA-2ag8A:
undetectable		 4q0bA-2ag8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_C_NMYC600_1
(BIFUNCTIONAL AAC/APH)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 12 ASP A  59
ASP A  58
TYR A   4
SER A  49
GLU A  47
 None
 1.14A 5iqeC-2ag8A:
1.8		 5iqeC-2ag8A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 12 GLY A 118
GLY A 120
SER A 122
VAL A  15
ALA A  14
 None
 0.92A 5kpcA-2ag8A:
4.0		 5kpcA-2ag8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 9 VAL A  46
LEU A  40
ILE A  62
LEU A  52
ALA A  16
 None
 1.36A 5og9A-2ag8A:
undetectable		 5og9A-2ag8A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		4 / 6 VAL A  60
LYS A   1
ILE A  62
TYR A  25
 None
 1.37A 5q1sA-2ag8A:
undetectable		 5q1sA-2ag8A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		3 / 3 LEU A 175
THR A 113
ASN A 112
 None
NAP  A 311 ( 4.7A)
None
 0.71A 6baaE-2ag8A:
undetectable		 6baaE-2ag8A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		3 / 3 LEU A 175
THR A 113
ASN A 112
 None
NAP  A 311 ( 4.7A)
None
 0.71A 6baaF-2ag8A:
undetectable		 6baaF-2ag8A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		3 / 3 LEU A 175
THR A 113
ASN A 112
 None
NAP  A 311 ( 4.7A)
None
 0.72A 6baaG-2ag8A:
undetectable		 6baaG-2ag8A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		3 / 3 LEU A 175
THR A 113
ASN A 112
 None
NAP  A 311 ( 4.7A)
None
 0.72A 6baaH-2ag8A:
undetectable		 6baaH-2ag8A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Neisseria
meningitidis) 		5 / 10 MET A 142
SER A 144
GLY A  18
ALA A  13
GLY A 115
 None
 1.11A 6hqbA-2ag8A:
2.5
6hqbJ-2ag8A:
undetectable		 6hqbA-2ag8A:
15.97
6hqbJ-2ag8A:
8.75