SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2agk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 2agk 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 6 THR A 172
LEU A 122
GLY A 127
LYS A 100
 None
 1.25A 1gtiC-2agkA:
undetectable		 1gtiC-2agkA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2agk 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A 136
GLY A  84
THR A 104
ILE A 102
 EDO  A1005 (-3.0A)
None
EDO  A1005 (-3.8A)
None
 0.89A 1gtnD-2agkA:
undetectable
1gtnE-2agkA:
undetectable		 1gtnD-2agkA:
16.40
1gtnE-2agkA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2agk 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 11 SER A 136
LEU A 135
ILE A 131
THR A 172
ILE A 102
 EDO  A1005 (-3.0A)
None
None
None
None
 1.14A 1pkvA-2agkA:
undetectable
1pkvB-2agkA:
undetectable		 1pkvA-2agkA:
18.78
1pkvB-2agkA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2agk 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 102
SER A 136
LEU A 135
ILE A 131
THR A 172
 None
EDO  A1005 (-3.0A)
None
None
None
 1.11A 1pkvA-2agkA:
undetectable
1pkvB-2agkA:
undetectable		 1pkvA-2agkA:
18.78
1pkvB-2agkA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 2agk 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 240
GLY A 187
GLY A 188
ILE A 189
VAL A 248
 None
 0.92A 1sdtA-2agkA:
undetectable		 1sdtA-2agkA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2agk 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 193
LEU A 192
LEU A 227
SER A 228
 None
 0.81A 3vhuA-2agkA:
undetectable		 3vhuA-2agkA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 2agk 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 193
LEU A 192
LEU A 227
ILE A 177
ILE A 209
 None
 1.23A 4j24B-2agkA:
undetectable		 4j24B-2agkA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2agk 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 116
VAL A 133
TYR A 171
ARG A 138
 None
 1.13A 4r7iA-2agkA:
undetectable		 4r7iA-2agkA:
20.28