SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2agm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NCW_H_BEZH601_0
(IMMUNOGLOBULIN IGG2A)		 2agm POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 9 ALA A 128
TYR A 112
LEU A 129
GLY A 131
GLY A 108
 None
 1.27A 1ncwH-2agmA:
undetectable
1ncwL-2agmA:
undetectable		 1ncwH-2agmA:
20.66
1ncwL-2agmA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2agm POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 9 ALA A 128
TYR A 112
LEU A 129
GLY A 131
GLY A 108
 None
 1.23A 1ru9H-2agmA:
0.0
1ru9L-2agmA:
0.0		 1ru9H-2agmA:
20.66
1ru9L-2agmA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2agm POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 10 ALA A 128
TYR A 112
LEU A 129
GLY A 131
GLY A 108
 None
 1.23A 1ruaH-2agmA:
0.0
1ruaL-2agmA:
0.0		 1ruaH-2agmA:
20.66
1ruaL-2agmA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2agm POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 8 ALA A 128
TYR A 112
LEU A 129
GLY A 131
GLY A 108
 None
 1.25A 1rukH-2agmA:
undetectable
1rukL-2agmA:
undetectable		 1rukH-2agmA:
20.66
1rukL-2agmA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2agm POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 9 ALA A 128
TYR A 112
LEU A 129
GLY A 131
GLY A 108
 None
 1.24A 1rulH-2agmA:
undetectable
1rulL-2agmA:
undetectable		 1rulH-2agmA:
20.66
1rulL-2agmA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUM_H_BEZH1601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2agm POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 9 ALA A 128
TYR A 112
LEU A 129
GLY A 131
GLY A 108
 None
 1.25A 1rumH-2agmA:
undetectable
1rumL-2agmA:
undetectable		 1rumH-2agmA:
20.66
1rumL-2agmA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUP_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2agm POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		5 / 9 ALA A 128
TYR A 112
LEU A 129
GLY A 131
GLY A 108
 None
 1.27A 1rupH-2agmA:
undetectable
1rupL-2agmA:
undetectable		 1rupH-2agmA:
20.66
1rupL-2agmA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2agm POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		4 / 5 VAL A  53
SER A  85
VAL A 143
SER A  55
 None
 1.13A 2j9cA-2agmA:
undetectable
2j9cB-2agmA:
undetectable
2j9cC-2agmA:
undetectable		 2j9cA-2agmA:
18.12
2j9cB-2agmA:
18.12
2j9cC-2agmA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 2agm POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		3 / 3 LEU A 153
GLU A 154
SER A 159
 None
 0.78A 4ccqA-2agmA:
undetectable		 4ccqA-2agmA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 2agm POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		4 / 7 GLY A 131
ASP A 130
GLY A 108
GLU A 107
 None
 0.82A 4koeA-2agmA:
undetectable
4koeB-2agmA:
undetectable
4koeD-2agmA:
undetectable		 4koeA-2agmA:
16.29
4koeB-2agmA:
16.29
4koeD-2agmA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2agm POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		4 / 7 GLY A 131
ASP A 130
GLY A 108
GLU A 107
 None
 0.87A 4z53A-2agmA:
undetectable
4z53B-2agmA:
undetectable		 4z53A-2agmA:
13.81
4z53B-2agmA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2agm POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		3 / 3 ARG A  62
LYS A 114
GLU A 126
 None
 0.75A 5d0yA-2agmA:
undetectable		 5d0yA-2agmA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2agm POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4
(Azotobacter
vinelandii) 		4 / 7 GLY A  88
VAL A 143
ASP A  83
VAL A 142
 None
 0.82A 5ik1A-2agmA:
undetectable		 5ik1A-2agmA:
19.95