SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ah5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2ah5 COG0546: PREDICTED
PHOSPHATASES
(Streptococcus
pneumoniae) 		4 / 8 VAL A 205
TYR A 103
ILE A   4
LEU A  96
 None
 0.92A 1igxA-2ah5A:
undetectable		 1igxA-2ah5A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ah5 COG0546: PREDICTED
PHOSPHATASES
(Streptococcus
pneumoniae) 		5 / 11 THR A 105
PHE A 126
PHE A 125
LEU A 178
VAL A 205
 None
 1.43A 1q23G-2ah5A:
0.0		 1q23G-2ah5A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 2ah5 COG0546: PREDICTED
PHOSPHATASES
(Streptococcus
pneumoniae) 		4 / 7 SER A  18
TYR A  71
ILE A  22
ASP A  12
 None
 1.12A 3bu1A-2ah5A:
undetectable		 3bu1A-2ah5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 2ah5 COG0546: PREDICTED
PHOSPHATASES
(Streptococcus
pneumoniae) 		4 / 5 TYR A  28
THR A  27
PHE A  26
LEU A  33
 None
 0.76A 3qelC-2ah5A:
2.1		 3qelC-2ah5A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 2ah5 COG0546: PREDICTED
PHOSPHATASES
(Streptococcus
pneumoniae) 		3 / 3 LYS A 201
PRO A 202
LEU A 203
 None
 0.73A 3tpxE-2ah5A:
undetectable		 3tpxE-2ah5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 2ah5 COG0546: PREDICTED
PHOSPHATASES
(Streptococcus
pneumoniae) 		5 / 12 LEU A  96
ILE A   7
LEU A 147
PHE A   9
ALA A 170
 None
 0.98A 3uwlB-2ah5A:
undetectable		 3uwlB-2ah5A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 2ah5 COG0546: PREDICTED
PHOSPHATASES
(Streptococcus
pneumoniae) 		5 / 12 LEU A  85
LEU A  96
PHE A   9
ASP A  10
ASP A 166
 None
 1.49A 4j7xJ-2ah5A:
4.9		 4j7xJ-2ah5A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 2ah5 COG0546: PREDICTED
PHOSPHATASES
(Streptococcus
pneumoniae) 		5 / 10 ASP A  12
ALA A  25
SER A  18
SER A  19
GLY A  21
 None
 1.37A 4xp1A-2ah5A:
undetectable		 4xp1A-2ah5A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ah5 COG0546: PREDICTED
PHOSPHATASES
(Streptococcus
pneumoniae) 		4 / 9 SER A 132
ALA A 136
GLU A 135
ILE A 129
 None
 0.87A 4xtaA-2ah5A:
undetectable		 4xtaA-2ah5A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ah5 COG0546: PREDICTED
PHOSPHATASES
(Streptococcus
pneumoniae) 		4 / 6 ILE A  20
ILE A  89
PHE A 184
PHE A 125
 None
 0.97A 5vkqB-2ah5A:
undetectable
5vkqC-2ah5A:
undetectable		 5vkqB-2ah5A:
7.74
5vkqC-2ah5A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ah5 COG0546: PREDICTED
PHOSPHATASES
(Streptococcus
pneumoniae) 		4 / 6 ILE A  20
ILE A  89
PHE A 184
PHE A 125
 None
 0.96A 5vkqC-2ah5A:
undetectable
5vkqD-2ah5A:
undetectable		 5vkqC-2ah5A:
7.74
5vkqD-2ah5A:
7.74