SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ahd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2ahd PHOSPHODIESTERASE
MJ0936
(Methanocaldococc
us
jannaschii) 		3 / 3 ILE A  32
ILE A   5
THR A  56
 None
 0.60A 1rg7A-2ahdA:
undetectable		 1rg7A-2ahdA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2ahd PHOSPHODIESTERASE
MJ0936
(Methanocaldococc
us
jannaschii) 		4 / 8 HIS A  10
ASP A  36
HIS A 122
ASP A   8
 None
 1.05A 2xadA-2ahdA:
undetectable		 2xadA-2ahdA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2ahd PHOSPHODIESTERASE
MJ0936
(Methanocaldococc
us
jannaschii) 		4 / 8 HIS A  10
ASP A  36
HIS A 122
ASP A   8
 None
 1.04A 2xadB-2ahdA:
undetectable		 2xadB-2ahdA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2ahd PHOSPHODIESTERASE
MJ0936
(Methanocaldococc
us
jannaschii) 		4 / 8 HIS A  10
ASP A  36
HIS A 122
ASP A   8
 None
 1.04A 2xadC-2ahdA:
undetectable		 2xadC-2ahdA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2ahd PHOSPHODIESTERASE
MJ0936
(Methanocaldococc
us
jannaschii) 		4 / 8 HIS A  10
ASP A  36
HIS A 122
ASP A   8
 None
 1.04A 2xadD-2ahdA:
undetectable		 2xadD-2ahdA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 2ahd PHOSPHODIESTERASE
MJ0936
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A  97
HIS A 120
HIS A  99
 None
 0.81A 3mihA-2ahdA:
undetectable		 3mihA-2ahdA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 2ahd PHOSPHODIESTERASE
MJ0936
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A  99
HIS A  97
HIS A 120
 None
 0.70A 3mihA-2ahdA:
undetectable		 3mihA-2ahdA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 2ahd PHOSPHODIESTERASE
MJ0936
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A 120
HIS A  99
HIS A  97
 None
 0.43A 3mihA-2ahdA:
undetectable		 3mihA-2ahdA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 2ahd PHOSPHODIESTERASE
MJ0936
(Methanocaldococc
us
jannaschii) 		5 / 12 HIS A 120
ALA A 107
HIS A  97
SER A   7
ASP A   8
 None
 1.36A 4aqlA-2ahdA:
3.3		 4aqlA-2ahdA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 2ahd PHOSPHODIESTERASE
MJ0936
(Methanocaldococc
us
jannaschii) 		6 / 12 PHE A  46
GLY A   4
GLY A 151
ALA A  51
HIS A  33
ILE A  53
 None
 1.21A 4krhA-2ahdA:
undetectable		 4krhA-2ahdA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 2ahd PHOSPHODIESTERASE
MJ0936
(Methanocaldococc
us
jannaschii) 		6 / 12 PHE A  46
GLY A   4
GLY A 151
ALA A  51
HIS A  33
ILE A  53
 None
 1.22A 4krhB-2ahdA:
2.3		 4krhB-2ahdA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 2ahd PHOSPHODIESTERASE
MJ0936
(Methanocaldococc
us
jannaschii) 		6 / 12 PHE A  46
PHE A 126
GLY A   4
GLY A 151
ALA A  51
ILE A  53
 None
 1.13A 4krhB-2ahdA:
2.3		 4krhB-2ahdA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2ahd PHOSPHODIESTERASE
MJ0936
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A  49
ILE A  16
ALA A  19
ILE A  20
ILE A 150
 None
 0.92A 5mvmD-2ahdA:
undetectable
5mvmE-2ahdA:
undetectable		 5mvmD-2ahdA:
19.02
5mvmE-2ahdA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2ahd PHOSPHODIESTERASE
MJ0936
(Methanocaldococc
us
jannaschii) 		5 / 6 ASP A  36
ASP A   8
HIS A  10
HIS A 122
HIS A  97
 None
 1.23A 5ncdA-2ahdA:
undetectable
5ncdD-2ahdA:
undetectable		 5ncdA-2ahdA:
20.61
5ncdD-2ahdA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2ahd PHOSPHODIESTERASE
MJ0936
(Methanocaldococc
us
jannaschii) 		5 / 6 ASP A  36
ASP A   8
HIS A  10
HIS A 122
HIS A  97
 None
 1.22A 5ncdB-2ahdA:
3.4
5ncdC-2ahdA:
undetectable		 5ncdB-2ahdA:
20.61
5ncdC-2ahdA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2ahd PHOSPHODIESTERASE
MJ0936
(Methanocaldococc
us
jannaschii) 		5 / 8 ASP A  36
ASP A   8
HIS A  10
HIS A 122
HIS A  97
 None
 1.23A 5nekD-2ahdA:
undetectable		 5nekD-2ahdA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 2ahd PHOSPHODIESTERASE
MJ0936
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A  19
LEU A  49
ILE A  53
CYH A  34
PHE A  37
 None
 1.38A 5vlmB-2ahdA:
undetectable		 5vlmB-2ahdA:
20.00