SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ahr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 2ahr PUTATIVE PYRROLINE
CARBOXYLATE
REDUCTASE
(Streptococcus
pyogenes) 		4 / 6 LEU A 106
VAL A 137
VAL A  61
GLN A  81
 None
 1.12A 1e7aB-2ahrA:
undetectable		 1e7aB-2ahrA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2ahr PUTATIVE PYRROLINE
CARBOXYLATE
REDUCTASE
(Streptococcus
pyogenes) 		4 / 4 ILE A  84
LEU A  54
VAL A  58
ILE A   3
 None
 0.93A 1fm6D-2ahrA:
undetectable		 1fm6D-2ahrA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2ahr PUTATIVE PYRROLINE
CARBOXYLATE
REDUCTASE
(Streptococcus
pyogenes) 		4 / 5 ILE A  83
ILE A  15
ILE A   6
LEU A 123
 None
 0.83A 1zgyA-2ahrA:
undetectable		 1zgyA-2ahrA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 2ahr PUTATIVE PYRROLINE
CARBOXYLATE
REDUCTASE
(Streptococcus
pyogenes) 		4 / 7 ILE A  84
ILE A  55
LEU A  54
ILE A   6
 None
 0.88A 2q83A-2ahrA:
undetectable		 2q83A-2ahrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 2ahr PUTATIVE PYRROLINE
CARBOXYLATE
REDUCTASE
(Streptococcus
pyogenes) 		5 / 11 ALA A 253
LEU A 256
ARG A  94
ILE A  90
PRO A  67
 None
None
NA  A1257 (-4.5A)
None
NAP  A1500 (-4.1A)
 1.37A 3bpxA-2ahrA:
undetectable
3bpxB-2ahrA:
undetectable		 3bpxA-2ahrA:
18.92
3bpxB-2ahrA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2ahr PUTATIVE PYRROLINE
CARBOXYLATE
REDUCTASE
(Streptococcus
pyogenes) 		5 / 10 ILE A  84
ILE A  83
VAL A  99
VAL A  58
LEU A 133
 None
 1.32A 3em0A-2ahrA:
undetectable		 3em0A-2ahrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ahr PUTATIVE PYRROLINE
CARBOXYLATE
REDUCTASE
(Streptococcus
pyogenes) 		5 / 12 GLY A  30
SER A  31
LEU A  33
ILE A   5
ILE A  27
 NAP  A1500 (-4.2A)
NAP  A1500 (-2.7A)
None
None
None
 0.89A 3mb5A-2ahrA:
3.6		 3mb5A-2ahrA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 2ahr PUTATIVE PYRROLINE
CARBOXYLATE
REDUCTASE
(Streptococcus
pyogenes) 		4 / 5 ILE A 108
THR A 121
THR A 147
PHE A 144
 None
 1.09A 3snfA-2ahrA:
undetectable		 3snfA-2ahrA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 2ahr PUTATIVE PYRROLINE
CARBOXYLATE
REDUCTASE
(Streptococcus
pyogenes) 		4 / 6 PRO A 110
GLY A  64
ALA A  14
GLN A  68
 NAP  A1500 (-4.4A)
NAP  A1500 (-4.9A)
None
None
 1.13A 4g0uA-2ahrA:
undetectable		 4g0uA-2ahrA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 2ahr PUTATIVE PYRROLINE
CARBOXYLATE
REDUCTASE
(Streptococcus
pyogenes) 		4 / 5 HIS A  51
ALA A  48
SER A  29
GLY A  30
 NAP  A1500 (-4.0A)
None
None
NAP  A1500 (-4.2A)
 1.05A 5yodB-2ahrA:
undetectable		 5yodB-2ahrA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 2ahr PUTATIVE PYRROLINE
CARBOXYLATE
REDUCTASE
(Streptococcus
pyogenes) 		4 / 5 HIS A  51
ALA A  48
SER A  29
GLY A  30
 NAP  A1500 (-4.0A)
None
None
NAP  A1500 (-4.2A)
 1.06A 5yodD-2ahrA:
undetectable		 5yodD-2ahrA:
22.53