SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aif'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 2aif RIBOSOMAL PROTEIN
L7A
(Cryptosporidium
parvum) 		5 / 11 ILE A  27
ALA A  19
VAL A  86
LEU A  40
ALA A 107
 None
 1.04A 1n4hA-2aifA:
undetectable		 1n4hA-2aifA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2aif RIBOSOMAL PROTEIN
L7A
(Cryptosporidium
parvum) 		4 / 7 GLY A 114
SER A 111
SER A 118
GLU A  57
 None
 0.92A 2c8aB-2aifA:
undetectable		 2c8aB-2aifA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2aif RIBOSOMAL PROTEIN
L7A
(Cryptosporidium
parvum) 		4 / 7 GLY A 114
SER A 111
SER A 118
GLU A  57
 None
 0.93A 2c8aD-2aifA:
undetectable		 2c8aD-2aifA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 2aif RIBOSOMAL PROTEIN
L7A
(Cryptosporidium
parvum) 		5 / 10 CYH A  98
GLY A  43
ALA A 107
ALA A  47
THR A 110
 None
 1.12A 3ucjA-2aifA:
undetectable		 3ucjA-2aifA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 2aif RIBOSOMAL PROTEIN
L7A
(Cryptosporidium
parvum) 		5 / 10 CYH A  98
GLY A  43
ALA A 107
ALA A  47
THR A 110
 None
 1.13A 3ucjB-2aifA:
undetectable		 3ucjB-2aifA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2aif RIBOSOMAL PROTEIN
L7A
(Cryptosporidium
parvum) 		5 / 11 VAL A 104
ALA A 107
LEU A  94
LEU A  40
GLY A  99
 None
 1.14A 3zosA-2aifA:
undetectable
3zosB-2aifA:
undetectable		 3zosA-2aifA:
20.20
3zosB-2aifA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 2aif RIBOSOMAL PROTEIN
L7A
(Cryptosporidium
parvum) 		4 / 6 ILE A  28
ARG A  96
GLY A  95
VAL A 100
 None
 1.08A 4oltB-2aifA:
undetectable		 4oltB-2aifA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 2aif RIBOSOMAL PROTEIN
L7A
(Cryptosporidium
parvum) 		5 / 11 VAL A  59
THR A 110
TYR A  85
PRO A  75
LEU A  61
 None
 1.43A 5jh7D-2aifA:
undetectable		 5jh7D-2aifA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 2aif RIBOSOMAL PROTEIN
L7A
(Cryptosporidium
parvum) 		5 / 9 ASN A  24
ALA A  19
ILE A 128
VAL A  31
ILE A  27
 None
 1.06A 5kr0A-2aifA:
undetectable		 5kr0A-2aifA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2aif RIBOSOMAL PROTEIN
L7A
(Cryptosporidium
parvum) 		5 / 10 VAL A 104
GLY A  95
LEU A  61
ILE A  27
ALA A 107
 None
 1.04A 5vm8B-2aifA:
undetectable		 5vm8B-2aifA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2aif RIBOSOMAL PROTEIN
L7A
(Cryptosporidium
parvum) 		5 / 12 LEU A  40
VAL A 100
GLY A  43
ALA A  44
LEU A  51
 None
 1.38A 5x23A-2aifA:
undetectable		 5x23A-2aifA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2aif RIBOSOMAL PROTEIN
L7A
(Cryptosporidium
parvum) 		3 / 3 TYR A  85
ALA A  19
LEU A  18
 None
 0.66A 6ag0C-2aifA:
undetectable		 6ag0C-2aifA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 2aif RIBOSOMAL PROTEIN
L7A
(Cryptosporidium
parvum) 		3 / 3 THR A 110
ALA A  50
LYS A  49
 None
 0.76A 6fgcA-2aifA:
undetectable		 6fgcA-2aifA:
15.95