SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aip'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		4 / 8 HIS A  57
ASP A 189
GLY A 216
GLY A 226
 SO4  A 301 (-3.8A)
None
None
None
 0.56A 1aq7A-2aipA:
34.1		 1aq7A-2aipA:
39.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		4 / 5 ARG A  95
ALA A 177
ASP A  96
GLY A 175
 None
 0.91A 1e7bA-2aipA:
undetectable		 1e7bA-2aipA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		4 / 5 ARG A  95
ALA A 177
ASP A  96
GLY A 175
 None
 0.97A 1e7cA-2aipA:
undetectable		 1e7cA-2aipA:
17.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		5 / 12 HIS A  57
ASP A 189
SER A 195
GLY A 216
GLY A 226
 SO4  A 301 (-3.8A)
None
SO4  A 301 (-2.8A)
None
None
 0.79A 1etrH-2aipA:
30.4		 1etrH-2aipA:
31.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		4 / 8 ASP A 189
SER A 195
GLY A 216
GLY A 226
 None
SO4  A 301 (-2.8A)
None
None
 0.52A 1f5lA-2aipA:
10.5		 1f5lA-2aipA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		4 / 6 ASP A 189
SER A 195
GLY A 216
GLY A 226
 None
SO4  A 301 (-2.8A)
None
None
 0.67A 1tnlA-2aipA:
33.9		 1tnlA-2aipA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		4 / 6 ASP A 189
SER A 195
GLY A 216
GLY A 226
 None
SO4  A 301 (-2.8A)
None
None
 0.49A 2otvA-2aipA:
34.0		 2otvA-2aipA:
39.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
LEU A  53
 None
None
None
SO4  A 301 (-3.9A)
None
None
 1.42A 2oxtD-2aipA:
undetectable		 2oxtD-2aipA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		5 / 12 ASP A 189
SER A 195
GLY A 216
GLY A 226
TYR A 228
 None
SO4  A 301 (-2.8A)
None
None
None
 0.44A 2p16A-2aipA:
12.3		 2p16A-2aipA:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		4 / 6 ARG A  95
THR A 179
ALA A 177
PRO A 245
 None
 1.40A 2ql8A-2aipA:
undetectable
2ql8B-2aipA:
undetectable		 2ql8A-2aipA:
20.76
2ql8B-2aipA:
20.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		4 / 8 ASP A 189
SER A 195
GLY A 216
GLY A 226
 None
SO4  A 301 (-2.8A)
None
None
 0.65A 2vinA-2aipA:
9.4		 2vinA-2aipA:
34.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		5 / 12 ASP A 189
SER A 195
GLY A 216
GLY A 226
TYR A 228
 None
SO4  A 301 (-2.8A)
None
None
None
 0.39A 2w26A-2aipA:
11.3		 2w26A-2aipA:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		5 / 10 LEU A 151
VAL A  16
ILE A 138
GLY A 197
PRO A 155
 None
 1.09A 3el5A-2aipA:
undetectable		 3el5A-2aipA:
18.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		5 / 11 HIS A  57
ASP A 189
SER A 195
GLY A 216
GLY A 226
 SO4  A 301 (-3.8A)
None
SO4  A 301 (-2.8A)
None
None
 0.64A 3gy3A-2aipA:
34.7		 3gy3A-2aipA:
39.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		5 / 12 HIS A  57
ASP A 102
LYS A 192
GLY A 193
SER A 195
 SO4  A 301 (-3.8A)
None
SO4  A 301 (-4.4A)
SO4  A 301 (-3.9A)
SO4  A 301 (-2.8A)
 1.11A 3keeD-2aipA:
11.6		 3keeD-2aipA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		4 / 6 GLY A 211
MET A 139
ILE A 212
VAL A 231
 None
 1.15A 3kvvA-2aipA:
undetectable		 3kvvA-2aipA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		4 / 6 GLY A 211
MET A 139
ILE A 212
VAL A 231
 None
 1.13A 3kvvB-2aipA:
undetectable		 3kvvB-2aipA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		4 / 6 GLY A 211
MET A 139
ILE A 212
VAL A 231
 None
 1.15A 3kvvC-2aipA:
undetectable		 3kvvC-2aipA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		4 / 6 GLY A 211
MET A 139
ILE A 212
VAL A 231
 None
 1.08A 3kvvD-2aipA:
undetectable		 3kvvD-2aipA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		4 / 6 GLY A 211
MET A 139
ILE A 212
VAL A 231
 None
 1.12A 3kvvE-2aipA:
undetectable		 3kvvE-2aipA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		4 / 6 GLY A 211
MET A 139
ILE A 212
VAL A 231
 None
 1.13A 3kvvF-2aipA:
undetectable		 3kvvF-2aipA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		5 / 12 LYS A  16
GLY A 197
ILE A 212
ALA A  55
ASP A 194
 None
 0.91A 3nvkI-2aipA:
undetectable		 3nvkI-2aipA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		6 / 12 LEU A 151
ASP A 189
VAL A  16
ILE A 138
GLY A 197
PRO A 155
 None
 1.31A 3so9B-2aipA:
undetectable		 3so9B-2aipA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		4 / 7 ALA A 178
GLY A 175
ILE A  98
THR A  94
 None
 0.87A 3spkB-2aipA:
0.6		 3spkB-2aipA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		5 / 12 HIS A  57
ASP A 102
LYS A 192
GLY A 193
SER A 195
 SO4  A 301 (-3.8A)
None
SO4  A 301 (-4.4A)
SO4  A 301 (-3.9A)
SO4  A 301 (-2.8A)
 1.06A 3sufA-2aipA:
10.8		 3sufA-2aipA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
 None
None
None
SO4  A 301 (-3.9A)
None
None
 1.31A 4ctkC-2aipA:
undetectable		 4ctkC-2aipA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		4 / 6 GLY A 211
MET A 139
ILE A 212
VAL A 231
 None
 1.14A 4e1vF-2aipA:
undetectable		 4e1vF-2aipA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		4 / 5 LEU A  41
ALA A 149
THR A 145
ILE A  17
 None
 0.94A 4xe3B-2aipA:
undetectable		 4xe3B-2aipA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
 None
None
None
SO4  A 301 (-3.9A)
None
None
 1.30A 5eiwC-2aipA:
undetectable		 5eiwC-2aipA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
 None
None
None
SO4  A 301 (-3.9A)
None
None
 1.32A 5ekxB-2aipA:
undetectable		 5ekxB-2aipA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		4 / 4 ASN A 161
LEU A 163
SER A 134
LEU A 181
 None
None
SO4  A 302 (-2.3A)
None
 1.37A 5kb5A-2aipA:
undetectable		 5kb5A-2aipA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
 None
None
None
SO4  A 301 (-3.9A)
None
None
 1.32A 5m5bA-2aipA:
undetectable		 5m5bA-2aipA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 2aip PROTEIN C ACTIVATOR
(Agkistrodon
contortrix) 		3 / 3 HIS A  71
ASN A  72
LEU A  73
 None
 0.90A 6f7lB-2aipA:
undetectable		 6f7lB-2aipA:
20.63