SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aiz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 12 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.05A 1cqeA-2aizP:
undetectable		 1cqeA-2aizP:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 12 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.04A 1cqeB-2aizP:
undetectable		 1cqeB-2aizP:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 12 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.02A 1eqhB-2aizP:
undetectable		 1eqhB-2aizP:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 12 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.07A 2aylA-2aizP:
undetectable		 2aylA-2aizP:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 12 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.06A 2aylB-2aizP:
undetectable		 2aylB-2aizP:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 12 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.04A 3ln1A-2aizP:
undetectable		 3ln1A-2aizP:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 12 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.03A 3ln1B-2aizP:
undetectable		 3ln1B-2aizP:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 12 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.03A 3ln1C-2aizP:
undetectable		 3ln1C-2aizP:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 12 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.04A 3ln1D-2aizP:
undetectable		 3ln1D-2aizP:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 12 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.04A 3n8wA-2aizP:
undetectable		 3n8wA-2aizP:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 12 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.01A 3nt1A-2aizP:
undetectable		 3nt1A-2aizP:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 12 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 0.99A 3nt1B-2aizP:
undetectable		 3nt1B-2aizP:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 12 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 0.97A 3pghC-2aizP:
undetectable		 3pghC-2aizP:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 12 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 0.97A 3pghD-2aizP:
undetectable		 3pghD-2aizP:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 12 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.06A 3rr3A-2aizP:
undetectable		 3rr3A-2aizP:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 12 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.07A 3rr3B-2aizP:
undetectable		 3rr3B-2aizP:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 11 VAL P  66
LEU P 132
HIS P  52
LEU P  49
ALA P  53
 None
 1.04A 4p65B-2aizP:
undetectable
4p65D-2aizP:
undetectable
4p65G-2aizP:
undetectable
4p65H-2aizP:
undetectable		 4p65B-2aizP:
12.69
4p65D-2aizP:
12.69
4p65G-2aizP:
16.67
4p65H-2aizP:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 10 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 0.99A 4ph9A-2aizP:
undetectable		 4ph9A-2aizP:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 10 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 0.96A 4ph9B-2aizP:
undetectable		 4ph9B-2aizP:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 9 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.01A 4rs0A-2aizP:
undetectable		 4rs0A-2aizP:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 12 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.07A 5ikrB-2aizP:
undetectable		 5ikrB-2aizP:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 12 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.06A 5jvzA-2aizP:
undetectable		 5jvzA-2aizP:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 12 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.04A 5jvzB-2aizP:
undetectable		 5jvzB-2aizP:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		5 / 12 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.00A 5jw1A-2aizP:
undetectable		 5jw1A-2aizP:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 2aiz OUTER MEMBRANE
PROTEIN P6
(Haemophilus
influenzae) 		4 / 6 TYR P  55
LEU P 132
LYS P 103
LEU P  94
 None
 0.90A 5xooA-2aizP:
undetectable		 5xooA-2aizP:
22.90