SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aj3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2aj3 FAB M18, HEAVY CHAIN
(Homo
sapiens) 		5 / 12 LEU B  18
ILE B  48
ARG B  38
LEU B  63
ARG B  66
 None
 1.28A 1dreA-2aj3B:
undetectable		 1dreA-2aj3B:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 2aj3 FAB M18, HEAVY CHAIN
(Homo
sapiens) 		5 / 12 ARG B  66
PRO B  41
LEU B  20
LEU B  18
ASP B  86
 None
 1.29A 1e7wA-2aj3B:
undetectable		 1e7wA-2aj3B:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2aj3 FAB M18, HEAVY CHAIN
(Homo
sapiens) 		5 / 12 LEU B  18
ILE B  48
ARG B  38
LEU B  63
ARG B  66
 None
 1.26A 1rh3A-2aj3B:
undetectable		 1rh3A-2aj3B:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2aj3 FAB M18, HEAVY CHAIN
(Homo
sapiens) 		3 / 3 ARG B  94
HIS B  96
TYR B  32
 None
 1.28A 4fu8A-2aj3B:
undetectable		 4fu8A-2aj3B:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2aj3 FAB M18, HEAVY CHAIN
(Homo
sapiens) 		4 / 8 SER B 128
LEU B 124
ALA B 137
SER B 127
 None
 1.00A 4ikjA-2aj3B:
3.6
4ikjB-2aj3B:
undetectable		 4ikjA-2aj3B:
20.63
4ikjB-2aj3B:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2aj3 FAB M18, HEAVY CHAIN
(Homo
sapiens) 		4 / 8 LEU B 124
ALA B 137
SER B 127
SER B 128
 None
 0.89A 4ikkA-2aj3B:
undetectable
4ikkB-2aj3B:
undetectable		 4ikkA-2aj3B:
20.63
4ikkB-2aj3B:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2aj3 FAB M18, HEAVY CHAIN
(Homo
sapiens) 		5 / 8 THR B 191
ASN B 155
VAL B 182
LEU B 138
GLY B 190
 None
 1.45A 4r3aA-2aj3B:
undetectable		 4r3aA-2aj3B:
23.89