SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aj4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 243
MET A 411
PHE A 426
LEU A  71
 None
 1.26A 1ea1A-2aj4A:
undetectable		 1ea1A-2aj4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 405
LEU A 429
ILE A  61
GLY A  58
LEU A  69
 None
 1.00A 1g50B-2aj4A:
undetectable		 1g50B-2aj4A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 405
LEU A 429
ILE A  61
GLY A  58
LEU A  69
 None
 0.99A 1g50C-2aj4A:
undetectable		 1g50C-2aj4A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 134
PHE A 137
LEU A 141
MET A 187
GLY A 188
 None
 1.32A 1uhoA-2aj4A:
undetectable		 1uhoA-2aj4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 308
ASP A 312
ASN A 306
 None
 0.66A 1vq1A-2aj4A:
undetectable		 1vq1A-2aj4A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		4 / 8 SER A 124
ARG A 103
PHE A 105
ASN A 125
 None
 1.24A 1zzuA-2aj4A:
undetectable		 1zzuA-2aj4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 472
GLY A 471
SER A 166
LEU A 168
 None
None
ANP  A 532 (-3.9A)
None
 0.79A 2oa1B-2aj4A:
undetectable		 2oa1B-2aj4A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		4 / 5 SER A 433
GLY A 467
GLU A 400
CYH A 443
 None
GLA  A 529 ( 4.2A)
None
None
 0.96A 3aiaA-2aj4A:
undetectable
3aiaB-2aj4A:
undetectable		 3aiaA-2aj4A:
17.34
3aiaB-2aj4A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		4 / 8 PRO A  89
GLY A 153
PRO A 150
ASN A 186
 None
 0.92A 3lslA-2aj4A:
undetectable
3lslD-2aj4A:
undetectable		 3lslA-2aj4A:
19.56
3lslD-2aj4A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 150
ASN A 186
PRO A  89
GLY A 153
 None
 0.91A 3lslA-2aj4A:
undetectable
3lslD-2aj4A:
undetectable		 3lslA-2aj4A:
19.56
3lslD-2aj4A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 182
LEU A 138
VAL A  83
GLY A 153
ALA A 152
 None
 1.27A 3pghB-2aj4A:
undetectable		 3pghB-2aj4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 405
LEU A 429
ILE A  61
GLY A  58
LEU A  69
 None
 1.07A 3q95A-2aj4A:
undetectable		 3q95A-2aj4A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 405
LEU A 429
ILE A  61
GLY A  58
LEU A  69
 None
 1.09A 3q95B-2aj4A:
undetectable		 3q95B-2aj4A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 9 SER A 523
GLY A 522
SER A 221
CYH A 223
GLY A 224
 None
 1.30A 4lb0A-2aj4A:
0.0		 4lb0A-2aj4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 217
VAL A 232
ALA A 240
GLY A 214
PHE A 234
 GLA  A 529 (-2.9A)
None
None
GLA  A 529 (-3.9A)
None
 1.21A 4mm5A-2aj4A:
undetectable		 4mm5A-2aj4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 217
VAL A 232
ALA A 240
GLY A 214
PHE A 234
 GLA  A 529 (-2.9A)
None
None
GLA  A 529 (-3.9A)
None
 1.11A 4mmeB-2aj4A:
undetectable		 4mmeB-2aj4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 217
VAL A 232
ALA A 240
GLY A 214
PHE A 234
 GLA  A 529 (-2.9A)
None
None
GLA  A 529 (-3.9A)
None
 1.19A 4mmfA-2aj4A:
3.2		 4mmfA-2aj4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 217
VAL A 232
ALA A 240
GLY A 214
PHE A 234
 GLA  A 529 (-2.9A)
None
None
GLA  A 529 (-3.9A)
None
 1.20A 4mmfB-2aj4A:
3.2		 4mmfB-2aj4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A 460
GLY A 427
GLY A 462
ASN A 431
ALA A 455
 None
 1.07A 4ubeA-2aj4A:
undetectable		 4ubeA-2aj4A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		3 / 3 SER A 523
ALA A  48
VAL A  47
 None
 0.53A 4x20C-2aj4A:
undetectable		 4x20C-2aj4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		3 / 3 THR A 291
HIS A 396
LEU A 310
 None
 0.83A 5axdA-2aj4A:
undetectable		 5axdA-2aj4A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		3 / 3 THR A 291
HIS A 396
LEU A 310
 None
 0.80A 5axdC-2aj4A:
undetectable		 5axdC-2aj4A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 522
SER A 523
CYH A 473
LEU A 168
PRO A 163
 None
 1.22A 5ergB-2aj4A:
undetectable		 5ergB-2aj4A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 402
LEU A 343
ARG A 277
 None
 0.55A 5hnzB-2aj4A:
undetectable		 5hnzB-2aj4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		3 / 3 MET A 314
GLU A 337
ARG A 338
 None
 1.03A 5tjyA-2aj4A:
undetectable		 5tjyA-2aj4A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		3 / 3 MET A 314
GLU A 337
ARG A 338
 None
 1.06A 5tjzA-2aj4A:
undetectable		 5tjzA-2aj4A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 229
LEU A  71
MET A 216
VAL A  68
GLY A  58
 None
None
GLA  A 529 ( 4.9A)
None
None
 1.21A 5x24A-2aj4A:
undetectable		 5x24A-2aj4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		3 / 3 SER A 523
ALA A  48
VAL A  47
 None
 0.53A 5xiwC-2aj4A:
undetectable		 5xiwC-2aj4A:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 321
LEU A 288
GLU A 348
LEU A 345
 None
 1.28A 5xooA-2aj4A:
undetectable		 5xooA-2aj4A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 138
SER A 136
PHE A 137
 None
 0.67A 6fgcA-2aj4A:
undetectable		 6fgcA-2aj4A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 281
TYR A 441
ASN A 275
TYR A 274
 None
None
None
GLA  A 529 (-4.8A)
 1.34A 6gneB-2aj4A:
undetectable		 6gneB-2aj4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 11 SER A 171
GLY A 469
GLY A 467
ASP A 449
LYS A 266
 ANP  A 532 (-3.1A)
None
GLA  A 529 ( 4.2A)
None
ANP  A 532 ( 3.1A)
 1.27A 6i5zD-2aj4A:
undetectable		 6i5zD-2aj4A:
22.52