SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aja'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 2aja ANKYRIN REPEAT
FAMILY PROTEIN
(Legionella
pneumophila) 		4 / 4 HIS A 140
LEU A  25
LEU A  67
LEU A  81
 None
 1.25A 1a4lD-2ajaA:
undetectable		 1a4lD-2ajaA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2aja ANKYRIN REPEAT
FAMILY PROTEIN
(Legionella
pneumophila) 		5 / 12 LEU A 144
CYH A 148
LEU A 150
ALA A 151
GLU A 119
 None
 1.29A 1s9pB-2ajaA:
undetectable		 1s9pB-2ajaA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2aja ANKYRIN REPEAT
FAMILY PROTEIN
(Legionella
pneumophila) 		6 / 12 LEU A 144
LEU A 147
CYH A 148
LEU A 150
ALA A 151
GLU A 119
 None
 1.29A 1s9pC-2ajaA:
undetectable		 1s9pC-2ajaA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2aja ANKYRIN REPEAT
FAMILY PROTEIN
(Legionella
pneumophila) 		5 / 12 LEU A 179
LEU A 182
CYH A 183
LEU A 185
ALA A 186
 None
 0.88A 1s9pC-2ajaA:
undetectable		 1s9pC-2ajaA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 2aja ANKYRIN REPEAT
FAMILY PROTEIN
(Legionella
pneumophila) 		5 / 12 LEU A 322
ASN A 320
LEU A 325
LEU A 301
LEU A 337
 None
 1.13A 1sqnB-2ajaA:
undetectable		 1sqnB-2ajaA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 2aja ANKYRIN REPEAT
FAMILY PROTEIN
(Legionella
pneumophila) 		5 / 11 ASN A 284
GLY A 236
ILE A 215
LEU A 219
PHE A 202
 None
 1.06A 1z11A-2ajaA:
undetectable		 1z11A-2ajaA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 2aja ANKYRIN REPEAT
FAMILY PROTEIN
(Legionella
pneumophila) 		5 / 11 ASN A 284
GLY A 236
ILE A 215
LEU A 219
PHE A 202
 None
 1.07A 1z11B-2ajaA:
undetectable		 1z11B-2ajaA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 2aja ANKYRIN REPEAT
FAMILY PROTEIN
(Legionella
pneumophila) 		5 / 10 ASN A 284
GLY A 236
ILE A 215
LEU A 219
PHE A 202
 None
 1.08A 1z11C-2ajaA:
undetectable		 1z11C-2ajaA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 2aja ANKYRIN REPEAT
FAMILY PROTEIN
(Legionella
pneumophila) 		5 / 10 ASN A 284
GLY A 236
ILE A 215
LEU A 219
PHE A 202
 None
 1.10A 1z11D-2ajaA:
undetectable		 1z11D-2ajaA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_B_P77B204_1
(PROTEIN S100-A4)		 2aja ANKYRIN REPEAT
FAMILY PROTEIN
(Legionella
pneumophila) 		4 / 6 MET A 224
CYH A 221
PHE A 243
PHE A 217
 None
 1.15A 3m0wB-2ajaA:
undetectable
3m0wJ-2ajaA:
undetectable		 3m0wB-2ajaA:
14.98
3m0wJ-2ajaA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2aja ANKYRIN REPEAT
FAMILY PROTEIN
(Legionella
pneumophila) 		4 / 8 PHE A 132
LEU A 141
ALA A 136
ALA A 135
 None
 0.77A 3ns1L-2ajaA:
undetectable		 3ns1L-2ajaA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 2aja ANKYRIN REPEAT
FAMILY PROTEIN
(Legionella
pneumophila) 		5 / 12 LEU A 176
LEU A 179
ASN A 180
LEU A 182
MET A 193
 None
 1.37A 3zqtA-2ajaA:
undetectable		 3zqtA-2ajaA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 2aja ANKYRIN REPEAT
FAMILY PROTEIN
(Legionella
pneumophila) 		4 / 7 GLY A 236
ILE A 215
LEU A 219
PHE A 202
 None
 0.67A 4ejjD-2ajaA:
undetectable		 4ejjD-2ajaA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2aja ANKYRIN REPEAT
FAMILY PROTEIN
(Legionella
pneumophila) 		4 / 7 LEU A 329
ASN A 331
ALA A 334
ILE A 306
 None
 0.92A 4eyrA-2ajaA:
undetectable		 4eyrA-2ajaA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2aja ANKYRIN REPEAT
FAMILY PROTEIN
(Legionella
pneumophila) 		3 / 3 ARG A 168
HIS A 165
TYR A 200
 None
 1.03A 4fu8A-2ajaA:
undetectable		 4fu8A-2ajaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2aja ANKYRIN REPEAT
FAMILY PROTEIN
(Legionella
pneumophila) 		3 / 3 ARG A 168
HIS A 165
TYR A 200
 None
 1.16A 4fu9A-2ajaA:
undetectable		 4fu9A-2ajaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 2aja ANKYRIN REPEAT
FAMILY PROTEIN
(Legionella
pneumophila) 		4 / 6 ILE A 194
TYR A 199
PHE A 202
THR A 314
 None
 1.17A 5g08A-2ajaA:
undetectable		 5g08A-2ajaA:
17.36