SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ajh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 ALA A 323
VAL A 303
TRP A 321
 None
 0.83A 1nt5A-2ajhA:
undetectable		 1nt5A-2ajhA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 ALA A 323
VAL A 303
TRP A 321
 None
 0.83A 1nt5B-2ajhA:
undetectable		 1nt5B-2ajhA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 5 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.06A 1t88B-2ajhA:
undetectable		 1t88B-2ajhA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRC_A_CAMA420_0
(CYTOCHROME P450-CAM)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.04A 1yrcA-2ajhA:
undetectable		 1yrcA-2ajhA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 ASN A 383
VAL A 359
TYR A 346
GLY A 340
THR A 257
 None
 1.49A 2f9wA-2ajhA:
undetectable
2f9wB-2ajhA:
undetectable		 2f9wA-2ajhA:
23.08
2f9wB-2ajhA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.03A 2feuA-2ajhA:
undetectable		 2feuA-2ajhA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 5 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.07A 2m56A-2ajhA:
undetectable		 2m56A-2ajhA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.17A 2zawA-2ajhA:
undetectable		 2zawA-2ajhA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.10A 2zuhA-2ajhA:
undetectable		 2zuhA-2ajhA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 VAL A 261
ALA A 323
TYR A 330
ILE A 282
THR A 305
 None
 1.26A 3dl9A-2ajhA:
undetectable		 3dl9A-2ajhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.04A 3fwfB-2ajhA:
undetectable		 3fwfB-2ajhA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.04A 3fwgA-2ajhA:
undetectable		 3fwgA-2ajhA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.07A 3fwgB-2ajhA:
undetectable		 3fwgB-2ajhA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWJ_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.05A 3fwjA-2ajhA:
undetectable		 3fwjA-2ajhA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 10 VAL A 261
VAL A 326
GLY A 333
VAL A 245
GLY A 331
 None
 1.16A 3ls4H-2ajhA:
undetectable		 3ls4H-2ajhA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 PHE A 348
ALA A 260
ALA A 268
THR A 305
 None
 0.91A 3mdrB-2ajhA:
undetectable		 3mdrB-2ajhA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 PHE A 253
CYH A 256
HIS A 311
 None
 1.28A 3u9fF-2ajhA:
undetectable		 3u9fF-2ajhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 PHE A 253
CYH A 256
HIS A 311
 None
 1.32A 3u9fL-2ajhA:
undetectable		 3u9fL-2ajhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.05A 3wrhE-2ajhA:
undetectable		 3wrhE-2ajhA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.06A 3wrjE-2ajhA:
undetectable		 3wrjE-2ajhA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.06A 4ek1A-2ajhA:
undetectable		 4ek1A-2ajhA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.05A 4g3rA-2ajhA:
undetectable		 4g3rA-2ajhA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.12A 4g3rB-2ajhA:
undetectable		 4g3rB-2ajhA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.12A 4kkyX-2ajhA:
undetectable		 4kkyX-2ajhA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 5 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.09A 4l49A-2ajhA:
undetectable		 4l49A-2ajhA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.04A 4l4cA-2ajhA:
undetectable		 4l4cA-2ajhA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 VAL A 230
LEU A 313
ILE A 399
ALA A 400
 None
 0.78A 4zf8A-2ajhA:
undetectable		 4zf8A-2ajhA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 PHE A 234
VAL A 236
VAL A 338
PHE A 253
VAL A 320
 None
None
MET  A 501 (-3.6A)
None
None
 1.19A 6ap6A-2ajhA:
undetectable		 6ap6A-2ajhA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 2ajh LEUCYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 PHE A 234
VAL A 236
VAL A 338
PHE A 253
VAL A 320
 None
None
MET  A 501 (-3.6A)
None
None
 1.18A 6ap6B-2ajhA:
undetectable		 6ap6B-2ajhA:
24.56