SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ajr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.90A 1bx4A-2ajrA:
25.0		 1bx4A-2ajrA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DGM_A_ADNA375_1
(ADENOSINE KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 9 ASN A   8
ASP A  12
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 1.14A 1dgmA-2ajrA:
25.1		 1dgmA-2ajrA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.98A 1liiA-2ajrA:
24.9		 1liiA-2ajrA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 1.01A 1likA-2ajrA:
25.1		 1likA-2ajrA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 SER A  50
ILE A  47
LEU A 257
GLY A  42
ALA A  10
 None
None
None
None
ACT  A 321 ( 4.4A)
 1.09A 1tsnA-2ajrA:
undetectable		 1tsnA-2ajrA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ALA A  10
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 ACT  A 321 ( 4.4A)
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.59A 2c49A-2ajrA:
26.6		 2c49A-2ajrA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 192
 ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 1.10A 2c49A-2ajrA:
26.6		 2c49A-2ajrA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 7 ALA A  10
ASP A  12
GLY A  39
GLY A  40
ASN A  44
 ACT  A 321 ( 4.4A)
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
 0.75A 2c49B-2ajrA:
25.2		 2c49B-2ajrA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 LEU A  52
VAL A  54
THR A   6
THR A   4
VAL A   2
LEU A  70
 None
 1.45A 2cbrA-2ajrA:
undetectable		 2cbrA-2ajrA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASP A  12
GLY A  39
GLY A  40
ASN A  44
GLY A 258
ASP A 261
 ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
None
 0.50A 2pkkA-2ajrA:
23.8		 2pkkA-2ajrA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 GLY A  39
GLY A  40
ASN A  44
GLN A 171
GLY A 258
 ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
None
 1.01A 2pkkA-2ajrA:
23.8		 2pkkA-2ajrA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		7 / 12 ALA A  10
ASP A  12
GLY A  39
GLY A  40
ASN A  44
GLY A 258
ASP A 261
 ACT  A 321 ( 4.4A)
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
None
 0.57A 2pkmA-2ajrA:
23.6		 2pkmA-2ajrA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 GLU A 316
ARG A 246
TYR A 229
VAL A 318
PHE A 208
 None
 1.15A 2qeoA-2ajrA:
undetectable		 2qeoA-2ajrA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		4 / 7 SER A  46
LEU A  70
PHE A  85
ILE A  81
 None
 0.74A 2v0mC-2ajrA:
undetectable		 2v0mC-2ajrA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 7 VAL A 139
ALA A 265
VAL A 264
GLY A  42
THR A   4
 None
 1.24A 2xrzB-2ajrA:
2.9		 2xrzB-2ajrA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_1
(GLUCOCORTICOID
RECEPTOR)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 ASN A   8
GLY A 142
GLN A 171
LEU A 156
THR A  92
 None
 1.47A 3cldA-2ajrA:
undetectable		 3cldA-2ajrA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		3 / 3 CYH A 137
PHE A 166
PHE A 168
 None
 1.03A 3cr5X-2ajrA:
undetectable		 3cr5X-2ajrA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A   7
ASN A   8
GLY A 142
GLN A 171
THR A  92
 None
 1.45A 3gn8A-2ajrA:
undetectable		 3gn8A-2ajrA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A   7
ASN A   8
GLY A 142
GLN A 171
THR A  92
 None
 1.50A 3gn8B-2ajrA:
0.0		 3gn8B-2ajrA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		4 / 8 GLY A  40
CYH A 153
GLY A  60
PHE A 124
 ACT  A 321 (-3.9A)
None
None
None
 0.99A 3ko0O-2ajrA:
undetectable
3ko0Q-2ajrA:
undetectable		 3ko0O-2ajrA:
16.01
3ko0Q-2ajrA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		7 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
GLY A 258
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
None
 0.86A 3uboA-2ajrA:
24.7		 3uboA-2ajrA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
GLY A  40
ASN A  44
ARG A 194
GLY A 258
ASP A 261
 None
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
None
None
 1.37A 3uboA-2ajrA:
24.7		 3uboA-2ajrA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.88A 3uboB-2ajrA:
25.5		 3uboB-2ajrA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
GLY A 258
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
None
 0.90A 3uq6A-2ajrA:
24.9		 3uq6A-2ajrA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASP A  12
GLY A  39
GLY A  40
ASN A  44
GLY A 258
ASP A 261
 ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
None
 0.42A 3uq6A-2ajrA:
24.9		 3uq6A-2ajrA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 ASP A  12
GLY A  40
ASN A  44
GLY A 258
ASP A 261
 ACT  A 321 (-3.1A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
None
 0.39A 3uq6B-2ajrA:
24.4		 3uq6B-2ajrA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
GLY A 258
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
None
 0.90A 3vaqA-2ajrA:
24.8		 3vaqA-2ajrA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASP A  12
GLY A  39
GLY A  40
ASN A  44
GLY A 258
ASP A 261
 ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
None
 0.46A 3vaqA-2ajrA:
24.8		 3vaqA-2ajrA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 ASN A   8
ASP A  12
GLY A  40
GLY A 258
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 (-3.9A)
None
None
 1.02A 3vaqB-2ajrA:
24.5		 3vaqB-2ajrA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 ASP A  12
GLY A  40
ASN A  44
GLY A 258
ASP A 261
 ACT  A 321 (-3.1A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
None
 0.44A 3vaqB-2ajrA:
24.5		 3vaqB-2ajrA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
GLY A 258
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
None
 0.90A 3vasA-2ajrA:
24.9		 3vasA-2ajrA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASP A  12
GLY A  39
GLY A  40
ASN A  44
GLY A 258
ASP A 261
 ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
None
 0.42A 3vasA-2ajrA:
24.9		 3vasA-2ajrA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
GLY A 258
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
None
None
 0.96A 3vasB-2ajrA:
24.5		 3vasB-2ajrA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASP A  12
GLY A  39
GLY A  40
ASN A  44
GLY A 258
ASP A 261
 ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
None
 0.41A 3vasB-2ajrA:
24.5		 3vasB-2ajrA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 9 ASN A  44
GLY A  39
SER A 141
GLY A  42
ASP A 261
 ACT  A 321 (-3.9A)
ACT  A 321 ( 4.3A)
None
None
None
 1.05A 3ztvA-2ajrA:
undetectable		 3ztvA-2ajrA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 9 ASN A  44
GLY A  40
GLY A  39
SER A 141
ASP A 261
 ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
ACT  A 321 ( 4.3A)
None
None
 1.16A 3ztvA-2ajrA:
undetectable		 3ztvA-2ajrA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		3 / 3 TYR A 299
MET A 300
ILE A  43
 None
 0.56A 4c8bB-2ajrA:
undetectable		 4c8bB-2ajrA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		3 / 3 LEU A 218
GLU A 220
SER A 222
 None
 0.71A 4ccqA-2ajrA:
4.7		 4ccqA-2ajrA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
ASN A  44
GLY A 258
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
None
None
 1.00A 4dc3A-2ajrA:
24.0		 4dc3A-2ajrA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		7 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
GLY A 258
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
None
 1.01A 4dc3B-2ajrA:
24.9		 4dc3B-2ajrA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.90A 4e3aA-2ajrA:
25.7		 4e3aA-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		7 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
GLY A 258
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
None
 0.88A 4e3aB-2ajrA:
25.8		 4e3aB-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		4 / 7 GLY A  42
THR A   4
LEU A  74
PHE A  85
 None
 0.91A 4ejjD-2ajrA:
undetectable		 4ejjD-2ajrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.88A 4jksA-2ajrA:
25.8		 4jksA-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.88A 4jksB-2ajrA:
25.9		 4jksB-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.89A 4jkuA-2ajrA:
25.8		 4jkuA-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.89A 4jkuB-2ajrA:
25.8		 4jkuB-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.88A 4k8cA-2ajrA:
25.9		 4k8cA-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.88A 4k8cB-2ajrA:
25.9		 4k8cB-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.88A 4k8kA-2ajrA:
25.8		 4k8kA-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.89A 4k8kB-2ajrA:
25.8		 4k8kB-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.87A 4k8pA-2ajrA:
25.9		 4k8pA-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.88A 4k8pB-2ajrA:
25.7		 4k8pB-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.87A 4k8tA-2ajrA:
25.8		 4k8tA-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.86A 4k8tB-2ajrA:
25.7		 4k8tB-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.88A 4k93A-2ajrA:
25.7		 4k93A-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.89A 4k93B-2ajrA:
25.8		 4k93B-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.87A 4k9cA-2ajrA:
25.9		 4k9cA-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.87A 4k9cB-2ajrA:
25.8		 4k9cB-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.88A 4k9iA-2ajrA:
25.7		 4k9iA-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.87A 4k9iB-2ajrA:
25.7		 4k9iB-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.87A 4kadA-2ajrA:
25.8		 4kadA-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.90A 4kadB-2ajrA:
25.7		 4kadB-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.89A 4kahA-2ajrA:
25.8		 4kahA-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.88A 4kahB-2ajrA:
25.8		 4kahB-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.88A 4kalA-2ajrA:
25.8		 4kalA-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.88A 4kalB-2ajrA:
25.8		 4kalB-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.88A 4kanA-2ajrA:
25.7		 4kanA-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.88A 4kanB-2ajrA:
25.8		 4kanB-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.87A 4kbeA-2ajrA:
25.8		 4kbeA-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.88A 4kbeB-2ajrA:
25.8		 4kbeB-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.88A 4lbgA-2ajrA:
25.7		 4lbgA-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.89A 4lbgB-2ajrA:
25.8		 4lbgB-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.88A 4lbxA-2ajrA:
25.7		 4lbxA-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.88A 4lbxB-2ajrA:
25.8		 4lbxB-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.88A 4lc4A-2ajrA:
25.8		 4lc4A-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.88A 4lc4B-2ajrA:
25.7		 4lc4B-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.87A 4lcaA-2ajrA:
25.9		 4lcaA-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.89A 4lcaB-2ajrA:
25.8		 4lcaB-2ajrA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 11 HIS A 274
TYR A 310
LEU A  49
ALA A 287
SER A 288
 None
 1.42A 4m83A-2ajrA:
undetectable		 4m83A-2ajrA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASN A   8
ASP A  12
GLY A  40
ASN A  44
GLY A 258
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
None
 1.04A 4n09A-2ajrA:
25.3		 4n09A-2ajrA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		7 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
GLY A 258
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
None
 1.03A 4n09B-2ajrA:
25.5		 4n09B-2ajrA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASP A  12
GLY A  39
GLY A  40
ASN A  44
GLY A 258
ASP A 261
 ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
None
 0.64A 4n09C-2ajrA:
25.6		 4n09C-2ajrA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		7 / 12 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
GLY A 258
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
None
 1.04A 4n09D-2ajrA:
25.5		 4n09D-2ajrA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 GLY A  39
THR A   6
LEU A   7
ASN A   8
ILE A 140
 ACT  A 321 ( 4.3A)
None
None
None
None
 1.19A 4n48A-2ajrA:
3.7		 4n48A-2ajrA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		4 / 8 LEU A 132
LEU A   3
VAL A 138
ILE A 140
 None
 0.86A 4oj4A-2ajrA:
undetectable		 4oj4A-2ajrA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		3 / 3 LEU A   7
LEU A  74
ASN A  84
 None
 0.71A 4otwA-2ajrA:
undetectable		 4otwA-2ajrA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A   7
ASN A   8
GLY A 142
GLN A 171
THR A  92
 None
 1.44A 4p6xA-2ajrA:
undetectable		 4p6xA-2ajrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 ASN A   8
GLY A 142
GLN A 171
LEU A 156
THR A  92
 None
 1.39A 4p6xE-2ajrA:
undetectable		 4p6xE-2ajrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A   7
ASN A   8
GLY A 142
GLN A 171
THR A  92
 None
 1.41A 4p6xE-2ajrA:
undetectable		 4p6xE-2ajrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A   7
ASN A   8
GLY A 142
GLN A 171
THR A  92
 None
 1.43A 4p6xI-2ajrA:
undetectable		 4p6xI-2ajrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 GLY A 258
ASN A  44
ILE A  99
SER A 254
HIS A 255
 None
ACT  A 321 (-3.9A)
None
None
None
 1.27A 4pooA-2ajrA:
4.9		 4pooA-2ajrA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.44A 4ubeA-2ajrA:
23.8		 4ubeA-2ajrA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A   7
ASN A   8
GLY A 142
GLN A 171
THR A  92
 None
 1.38A 4udcA-2ajrA:
undetectable		 4udcA-2ajrA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		3 / 3 LEU A 175
ARG A 178
ARG A 174
 None
 0.84A 4yiaB-2ajrA:
0.0		 4yiaB-2ajrA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		4 / 7 ILE A  47
LEU A  74
GLY A  40
LYS A  41
 None
None
ACT  A 321 (-3.9A)
None
 0.81A 4z69A-2ajrA:
undetectable		 4z69A-2ajrA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		5 / 12 VAL A 138
ILE A 179
LEU A 156
LEU A   7
VAL A   5
 None
 1.13A 5im2A-2ajrA:
1.6		 5im2A-2ajrA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		6 / 12 ASP A  12
GLY A  39
GLY A  40
ASN A  44
GLY A 258
ASP A 261
 ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
None
 0.38A 5kb5A-2ajrA:
25.5		 5kb5A-2ajrA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		4 / 5 ASP A 261
ASN A  44
ASP A  12
ASN A 110
 None
ACT  A 321 (-3.9A)
ACT  A 321 (-3.1A)
None
 1.16A 5vooA-2ajrA:
2.1		 5vooA-2ajrA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		4 / 5 ASP A 261
ASN A  44
ASP A  12
ASN A 110
 None
ACT  A 321 (-3.9A)
ACT  A 321 (-3.1A)
None
 1.11A 5vooB-2ajrA:
2.7		 5vooB-2ajrA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		4 / 5 ASP A 261
ASN A  44
ASP A  12
ASN A 110
 None
ACT  A 321 (-3.9A)
ACT  A 321 (-3.1A)
None
 1.10A 5vooC-2ajrA:
2.0		 5vooC-2ajrA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		4 / 5 ASP A 261
ASN A  44
ASP A  12
ASN A 110
 None
ACT  A 321 (-3.9A)
ACT  A 321 (-3.1A)
None
 1.11A 5vooD-2ajrA:
2.6		 5vooD-2ajrA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		4 / 5 ASP A 261
ASN A  44
ASP A  12
ASN A 110
 None
ACT  A 321 (-3.9A)
ACT  A 321 (-3.1A)
None
 1.13A 5vooE-2ajrA:
undetectable		 5vooE-2ajrA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		4 / 4 ASP A 261
ASN A  44
ASP A  12
ASN A 110
 None
ACT  A 321 (-3.9A)
ACT  A 321 (-3.1A)
None
 1.14A 5vooF-2ajrA:
2.6		 5vooF-2ajrA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		3 / 3 ASP A 261
ASN A  44
ASP A  12
 None
ACT  A 321 (-3.9A)
ACT  A 321 (-3.1A)
 0.80A 5vopA-2ajrA:
undetectable		 5vopA-2ajrA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2ajr SUGAR KINASE, PFKB
FAMILY
(Thermotoga
maritima) 		3 / 3 ASP A 261
ASN A  44
ASP A  12
 None
ACT  A 321 (-3.9A)
ACT  A 321 (-3.1A)
 0.80A 5vopB-2ajrA:
2.6		 5vopB-2ajrA:
24.28