SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ak3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 2ak3 ADENYLATE KINASE
ISOENZYME-3
(Bos
taurus) 		3 / 3 LYS A  18
ILE A  58
PHE A  57
 None
AMP  A 226 (-4.5A)
None
 0.68A 3j7zS-2ak3A:
undetectable
3j7za-2ak3A:
undetectable		 3j7zS-2ak3A:
20.00
3j7za-2ak3A:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ak3 ADENYLATE KINASE
ISOENZYME-3
(Bos
taurus) 		5 / 12 LEU A  39
GLY A  89
SER A  35
LEU A  77
ALA A  97
 None
AMP  A 226 (-4.7A)
None
None
None
 1.14A 3ou6A-2ak3A:
undetectable		 3ou6A-2ak3A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ak3 ADENYLATE KINASE
ISOENZYME-3
(Bos
taurus) 		5 / 12 LEU A  39
GLY A  89
SER A  35
LEU A  77
ALA A  97
 None
AMP  A 226 (-4.7A)
None
None
None
 1.14A 3ou6B-2ak3A:
undetectable		 3ou6B-2ak3A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ak3 ADENYLATE KINASE
ISOENZYME-3
(Bos
taurus) 		5 / 12 LEU A  39
GLY A  89
SER A  35
LEU A  77
ALA A  97
 None
AMP  A 226 (-4.7A)
None
None
None
 1.15A 3ou7B-2ak3A:
undetectable		 3ou7B-2ak3A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2ak3 ADENYLATE KINASE
ISOENZYME-3
(Bos
taurus) 		4 / 4 GLY A  19
LEU A 210
PHE A 209
ILE A 110
 SO4  A 227 (-3.3A)
None
None
None
 0.82A 4xv2A-2ak3A:
undetectable		 4xv2A-2ak3A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 2ak3 ADENYLATE KINASE
ISOENZYME-3
(Bos
taurus) 		4 / 7 VAL A  21
ILE A  25
VAL A 206
ILE A 202
 None
 0.78A 5bmvC-2ak3A:
4.3		 5bmvC-2ak3A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 2ak3 ADENYLATE KINASE
ISOENZYME-3
(Bos
taurus) 		5 / 11 ILE A  10
ASN A 111
LEU A 182
GLY A  89
ALA A  13
 None
None
None
AMP  A 226 (-4.7A)
None
 1.15A 5fctA-2ak3A:
undetectable		 5fctA-2ak3A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2ak3 ADENYLATE KINASE
ISOENZYME-3
(Bos
taurus) 		4 / 5 ILE A  10
LEU A   6
LYS A 213
VAL A 206
 None
 1.14A 5jmnB-2ak3A:
undetectable		 5jmnB-2ak3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 2ak3 ADENYLATE KINASE
ISOENZYME-3
(Bos
taurus) 		4 / 8 LEU A  87
GLU A  76
TRP A  85
ASN A  79
 None
 1.03A 6c71B-2ak3A:
undetectable		 6c71B-2ak3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 2ak3 ADENYLATE KINASE
ISOENZYME-3
(Bos
taurus) 		5 / 12 ILE A  10
ASN A 111
LEU A 182
GLY A  89
ALA A  13
 None
None
None
AMP  A 226 (-4.7A)
None
 1.13A 6r2eE-2ak3A:
undetectable		 6r2eE-2ak3A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 2ak3 ADENYLATE KINASE
ISOENZYME-3
(Bos
taurus) 		5 / 11 ILE A  10
ASN A 111
LEU A 182
GLY A  89
ALA A  13
 None
None
None
AMP  A 226 (-4.7A)
None
 1.14A 6r2eF-2ak3A:
undetectable		 6r2eF-2ak3A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 2ak3 ADENYLATE KINASE
ISOENZYME-3
(Bos
taurus) 		5 / 12 ILE A  10
ASN A 111
LEU A 182
GLY A  89
ALA A  13
 None
None
None
AMP  A 226 (-4.7A)
None
 1.07A 6r2eH-2ak3A:
undetectable		 6r2eH-2ak3A:
21.02