SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aka'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 2aka DYNAMIN-1
(Rattus
norvegicus) 		5 / 12 THR B 205
VAL B 174
LEU B 134
LEU B 172
LEU B  71
 None
 1.15A 1mx1C-2akaB:
1.9		 1mx1C-2akaB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 2aka DYNAMIN-1
(Rattus
norvegicus) 		5 / 11 LEU B  48
ILE B 204
GLY B 202
ILE B 201
VAL B  47
 None
 1.03A 2nnpB-2akaB:
undetectable		 2nnpB-2akaB:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 2aka DYNAMIN-1
(Rattus
norvegicus) 		5 / 12 LEU B  48
SER B  45
PRO B  58
VAL B  64
VAL B  97
 None
 1.26A 3aqiB-2akaB:
undetectable		 3aqiB-2akaB:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 2aka DYNAMIN-1
(Rattus
norvegicus) 		5 / 12 GLY B 233
GLY B 273
ALA B 177
LEU B 268
LEU B 207
 None
 1.18A 3mteA-2akaB:
undetectable		 3mteA-2akaB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 2aka DYNAMIN-1
(Rattus
norvegicus) 		5 / 10 LEU B 181
ALA B 186
ILE B 189
ILE B 201
LEU B 187
 None
 0.97A 3ogpA-2akaB:
undetectable		 3ogpA-2akaB:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 2aka DYNAMIN-1
(Rattus
norvegicus) 		5 / 12 GLY B 233
GLY B 273
ALA B 177
LEU B 268
LEU B 207
 None
 1.11A 3p2kB-2akaB:
undetectable		 3p2kB-2akaB:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2aka DYNAMIN-1
(Rattus
norvegicus) 		4 / 8 ALA B 190
VAL B 193
ASP B 194
LEU B 170
 None
 0.84A 3roxA-2akaB:
undetectable		 3roxA-2akaB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 2aka DYNAMIN-1
(Rattus
norvegicus) 		4 / 5 ILE B 152
PRO B 149
SER B 116
GLY B 114
 None
 0.98A 3tkdB-2akaB:
undetectable		 3tkdB-2akaB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 2aka DYNAMIN-1
(Rattus
norvegicus) 		4 / 5 ILE B 152
PRO B 149
SER B 116
GLY B 114
 None
 0.99A 3tkdA-2akaB:
undetectable		 3tkdA-2akaB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2aka DYNAMIN-1
(Rattus
norvegicus) 		5 / 12 LEU B  48
SER B  45
PRO B  58
VAL B  64
VAL B  97
 None
 1.29A 3w1wA-2akaB:
undetectable		 3w1wA-2akaB:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2aka DYNAMIN-1
(Rattus
norvegicus) 		5 / 12 VAL B  64
LEU B 134
THR B 133
PRO B  68
ARG B  67
 None
 1.37A 5hnxB-2akaB:
undetectable		 5hnxB-2akaB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2aka DYNAMIN-1
(Rattus
norvegicus) 		4 / 7 VAL B 124
ALA B  81
LEU B  71
LEU B  69
 None
 0.51A 5jq7A-2akaB:
undetectable		 5jq7A-2akaB:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 2aka DYNAMIN-1
(Rattus
norvegicus) 		4 / 5 SER B 175
VAL B 174
GLY B  38
ALA B 186
 None
 1.06A 5k50A-2akaB:
undetectable		 5k50A-2akaB:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LUH_B_SRYB303_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 2aka DYNAMIN-1
(Rattus
norvegicus) 		5 / 10 ASP B 194
ASP B  30
HIS B 288
ILE B 289
THR B 292
 None
 1.17A 5luhB-2akaB:
0.0		 5luhB-2akaB:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2aka DYNAMIN-1
(Rattus
norvegicus) 		5 / 12 LEU B 207
ASP B 215
LEU B 220
THR B 205
LEU B 187
 None
 1.20A 6b0lB-2akaB:
2.3		 6b0lB-2akaB:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA807_0
(GEPHYRIN)		 2aka DYNAMIN-1
(Rattus
norvegicus) 		4 / 4 PRO B  58
LEU B  69
VAL B  97
ARG B  98
 None
 1.34A 6fgdA-2akaB:
0.0		 6fgdA-2akaB:
20.41