SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2akc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		5 / 12 VAL A 113
GLY A 114
LEU A 164
TYR A 161
PHE A  26
 None
 1.31A 1a27A-2akcA:
undetectable		 1a27A-2akcA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		3 / 3 LEU A 169
SER A  88
ASN A 238
 None
 0.82A 1bx4A-2akcA:
undetectable		 1bx4A-2akcA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		4 / 6 PHE A  58
ALA A  62
GLY A  60
TYR A  61
 None
 1.09A 1gfzA-2akcA:
undetectable		 1gfzA-2akcA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		5 / 12 PHE A  87
LEU A 110
GLY A 209
ALA A 160
GLY A 188
 None
 0.92A 1igxA-2akcA:
0.5		 1igxA-2akcA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		5 / 11 VAL A 113
GLY A 114
LEU A 164
TYR A 161
PHE A  26
 None
 1.28A 1iolA-2akcA:
undetectable		 1iolA-2akcA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		5 / 8 GLY A 209
PHE A 213
LEU A 164
ARG A 215
GLY A 114
 None
 1.46A 1jhqA-2akcA:
undetectable		 1jhqA-2akcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		4 / 6 PHE A  58
ALA A  62
GLY A  60
TYR A  61
 None
 1.14A 1l5qA-2akcA:
0.9		 1l5qA-2akcA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		4 / 6 PHE A  58
ALA A  62
GLY A  60
TYR A  61
 None
 1.16A 1l5qB-2akcA:
undetectable		 1l5qB-2akcA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		4 / 6 PHE A  58
ALA A  62
GLY A  60
TYR A  61
 None
 1.10A 1l7xA-2akcA:
undetectable		 1l7xA-2akcA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		4 / 6 PHE A  58
ALA A  62
GLY A  60
TYR A  61
 None
 1.12A 1l7xB-2akcA:
undetectable		 1l7xB-2akcA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		3 / 3 PRO A 131
GLY A 195
TYR A  57
 None
 0.68A 2vouB-2akcA:
undetectable		 2vouB-2akcA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		3 / 3 PRO A 131
GLY A 195
TYR A  57
 None
 0.68A 2vouC-2akcA:
undetectable		 2vouC-2akcA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		5 / 12 GLY A 209
GLY A 205
LEU A 164
ALA A 118
ARG A 215
 None
 1.00A 2yqzA-2akcA:
undetectable		 2yqzA-2akcA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		3 / 3 PRO A 131
GLU A  55
TYR A  57
 None
 0.73A 2zmbA-2akcA:
undetectable		 2zmbA-2akcA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		4 / 5 PHE A  58
ALA A  62
GLY A  60
TYR A  61
 None
 1.16A 3bcrA-2akcA:
undetectable		 3bcrA-2akcA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		4 / 6 PHE A  58
ALA A  62
GLY A  60
TYR A  61
 None
 1.08A 3dd1B-2akcA:
undetectable		 3dd1B-2akcA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		4 / 6 PHE A  58
ALA A  62
GLY A  60
TYR A  61
 None
 1.13A 3ddsA-2akcA:
undetectable		 3ddsA-2akcA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		4 / 6 PHE A  58
ALA A  62
GLY A  60
TYR A  61
 None
 1.12A 3ddsB-2akcA:
undetectable		 3ddsB-2akcA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		4 / 6 PHE A  58
ALA A  62
GLY A  60
TYR A  61
 None
 1.12A 3ddwA-2akcA:
1.5		 3ddwA-2akcA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		4 / 6 PHE A  58
ALA A  62
GLY A  60
TYR A  61
 None
 1.13A 3ddwB-2akcA:
undetectable		 3ddwB-2akcA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		3 / 3 ARG A 191
VAL A 208
THR A 119
 WO4  A 501 (-3.7A)
None
None
 0.81A 3ndtA-2akcA:
undetectable		 3ndtA-2akcA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		3 / 3 ARG A 130
ASP A  53
ASP A  47
 WO4  A 501 (-2.7A)
None
None
 0.69A 4kicB-2akcA:
undetectable		 4kicB-2akcA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		4 / 7 ARG A 130
VAL A 133
TRP A 198
SER A 153
 WO4  A 501 (-2.7A)
None
None
None
 1.10A 4zphA-2akcA:
undetectable
4zphB-2akcA:
undetectable		 4zphA-2akcA:
20.56
4zphB-2akcA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		5 / 12 PHE A  26
LEU A 165
LEU A 107
ALA A 172
LEU A 233
 None
 1.19A 5iepA-2akcA:
0.0		 5iepA-2akcA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		5 / 12 TYR A 161
VAL A  91
THR A 100
VAL A 229
TYR A 116
 None
 1.00A 6djzA-2akcA:
undetectable		 6djzA-2akcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON
(Salmonella
enterica) 		4 / 8 ALA A 204
LEU A  39
ALA A 122
LYS A 123
 None
None
None
WO4  A 501 (-2.7A)
 0.82A 6mdqA-2akcA:
undetectable		 6mdqA-2akcA:
12.88