SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2akj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		4 / 4 HIS A 357
LEU A 418
LEU A 417
LEU A 396
 None
 1.13A 1a4lD-2akjA:
undetectable		 1a4lD-2akjA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		3 / 3 GLN A 172
ILE A  86
HIS A  97
 None
 0.73A 1fm9A-2akjA:
undetectable		 1fm9A-2akjA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		4 / 7 GLY A 231
THR A 201
THR A 197
ILE A 230
 None
 0.97A 1gtnJ-2akjA:
undetectable
1gtnK-2akjA:
undetectable		 1gtnJ-2akjA:
9.69
1gtnK-2akjA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		3 / 3 GLN A 172
ILE A  86
HIS A  97
 None
 0.73A 1k74A-2akjA:
undetectable		 1k74A-2akjA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		3 / 3 ARG A 309
GLY A 262
ASP A 243
 SRM  A 564 (-3.8A)
None
None
 0.46A 1kf6A-2akjA:
undetectable
1kf6B-2akjA:
undetectable		 1kf6A-2akjA:
22.42
1kf6B-2akjA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		5 / 12 LEU A 171
LEU A 163
ALA A 138
MET A 108
LEU A  95
 None
 1.30A 1kt5A-2akjA:
undetectable		 1kt5A-2akjA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		5 / 11 LEU A 171
LEU A 163
ALA A 138
MET A 108
LEU A  95
 None
 1.30A 1kt6A-2akjA:
undetectable		 1kt6A-2akjA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		5 / 11 LEU A 171
LEU A 163
ALA A 138
MET A 108
LEU A  95
 None
 1.33A 1kt7A-2akjA:
undetectable		 1kt7A-2akjA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		3 / 3 ARG A 351
ASP A 196
ASN A 202
 None
 0.95A 1nbhA-2akjA:
undetectable		 1nbhA-2akjA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		3 / 3 ARG A 351
ASP A 196
ASN A 202
 None
 0.92A 1nbhD-2akjA:
undetectable		 1nbhD-2akjA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		5 / 10 ALA A 278
LEU A 335
GLU A 320
LEU A 260
VAL A 261
 None
 1.18A 2bxeA-2akjA:
2.0		 2bxeA-2akjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		4 / 8 ASP A  85
LEU A  68
GLY A  64
HIS A  81
 None
 0.93A 3af0A-2akjA:
undetectable		 3af0A-2akjA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		3 / 3 TYR A 236
ASP A 190
HIS A 357
 None
 0.95A 3e23A-2akjA:
undetectable		 3e23A-2akjA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		3 / 3 LYS A 131
ILE A  65
PHE A  60
 None
 0.99A 3j7zS-2akjA:
undetectable
3j7za-2akjA:
undetectable		 3j7zS-2akjA:
11.63
3j7za-2akjA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		5 / 12 PRO A 191
VAL A 195
ASP A 196
PRO A 248
ASP A 234
 None
 1.10A 3m6vB-2akjA:
undetectable		 3m6vB-2akjA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		4 / 6 ILE A  65
LEU A  90
PHE A 106
GLY A 104
 None
 0.91A 3sj1X-2akjA:
undetectable		 3sj1X-2akjA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		5 / 8 GLY A 527
GLY A 517
GLY A 495
ILE A 546
VAL A 514
 None
 1.20A 3v1nA-2akjA:
undetectable		 3v1nA-2akjA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		4 / 5 ILE A 129
ALA A 138
MET A 381
ARG A 426
 None
 1.32A 4ac9B-2akjA:
undetectable
4ac9C-2akjA:
undetectable		 4ac9B-2akjA:
22.26
4ac9C-2akjA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		4 / 5 ILE A 129
ALA A 138
MET A 381
ARG A 426
 None
 1.30A 4acaB-2akjA:
undetectable
4acaC-2akjA:
undetectable		 4acaB-2akjA:
22.26
4acaC-2akjA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		4 / 5 ILE A 230
ALA A 245
HIS A 238
ARG A 143
 None
None
None
SRM  A 564 (-4.1A)
 1.32A 4acaB-2akjA:
undetectable
4acaC-2akjA:
undetectable		 4acaB-2akjA:
22.26
4acaC-2akjA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		4 / 7 ILE A  65
LEU A  90
PHE A 106
GLY A 104
 None
 0.80A 4hajA-2akjA:
undetectable		 4hajA-2akjA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		4 / 8 ILE A  65
LEU A  90
PHE A 106
GLY A 104
 None
 0.85A 4hb6A-2akjA:
undetectable		 4hb6A-2akjA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		4 / 7 ILE A  65
LEU A  90
PHE A 106
GLY A 104
 None
 0.86A 4hc3A-2akjA:
undetectable		 4hc3A-2akjA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		5 / 12 ILE A 148
LEU A 112
ARG A 123
THR A 141
LEU A 376
 None
None
None
SRM  A 564 (-2.9A)
None
 1.05A 4m6kA-2akjA:
undetectable		 4m6kA-2akjA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		4 / 8 PRO A 227
VAL A 178
VAL A 229
GLY A 183
 None
 0.93A 4mk4A-2akjA:
undetectable		 4mk4A-2akjA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		4 / 6 GLY A 517
GLN A 550
PHE A 551
ILE A 546
 None
 0.96A 4qogA-2akjA:
undetectable
4qogB-2akjA:
undetectable		 4qogA-2akjA:
17.63
4qogB-2akjA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		4 / 8 GLU A 395
ASN A 408
LEU A 186
GLY A 368
 None
 0.58A 4r3aA-2akjA:
1.3		 4r3aA-2akjA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		5 / 9 LEU A 299
LEU A 276
ARG A 323
LEU A 317
ILE A 314
 None
 1.36A 4ubsA-2akjA:
undetectable		 4ubsA-2akjA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		5 / 12 VAL A 286
ALA A 273
VAL A 326
LEU A 293
VAL A 178
 None
 1.20A 5tudD-2akjA:
undetectable		 5tudD-2akjA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		5 / 12 ILE A 194
ILE A 230
ALA A 245
ALA A 338
GLU A 341
 None
 1.01A 5vceA-2akjA:
undetectable		 5vceA-2akjA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		5 / 12 PHE A 255
ILE A 230
ALA A 245
ALA A 338
GLU A 341
 None
 1.07A 5vceA-2akjA:
undetectable		 5vceA-2akjA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		3 / 3 GLN A 172
ILE A  86
HIS A  97
 None
 0.69A 5z12B-2akjA:
undetectable		 5z12B-2akjA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST
(Spinacia
oleracea) 		3 / 3 HIS A 238
ARG A 350
ILE A 520
 None
 0.76A 6fgdA-2akjA:
2.1		 6fgdA-2akjA:
21.74